Virucidal potential of H<sub>2</sub>O<sub>2</sub>‐based spray against SARS‐CoV‐2 and biosafety in a dental environment

Santana, Lucas Alves da Mota; Pinho, John Nadson Andrade; Albuquerque, Hélio Igor Melo de; Souza, Liane Maciel de Almeida

doi:10.1111/odi.13778

Cited by 3 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it was observed in all RCTs (Table 2 , online Appendix S1 and S2 ), although PVP‐I was found to be efficient, the percentage and the time interval taken to test the efficacy against this virus was not consistent (methodological heterogeneity). 22 , 23 , 24 Chlorhexidine (CHX) as a combination of mouth rinse and oropharyngeal spray was found to be more effective than mouth rinse alone; cetylpyridinium chloride (CPC) did show promising results (Table 2 ). The summary on the potential RoB estimated on various studies, as presented in the online Appendix S1 , estimates high RoB in all study.…”

Section: Resultsmentioning

confidence: 99%

“…The summary on the potential RoB estimated on various studies, as presented in the online Appendix S1 , estimates high RoB in all study. 23 , 24 , 25 , 26 , 27 , 28 A study related to oral rinse PVP‐I reported thyroid dysfunction in 42% of their patients, the symptoms resolved following treatment discontinuation. 26 …”

Section: Resultsmentioning

confidence: 99%

“…Five studies identified for inclusion in the review were non‐randomized in vivo studies with small sample size (Table 1, Clinical heterogeneity). Furthermore, it was observed in all RCTs (Table 2, online Appendix and ), although PVP‐I was found to be efficient, the percentage and the time interval taken to test the efficacy against this virus was not consistent (methodological heterogeneity) 22‐24 . Chlorhexidine (CHX) as a combination of mouth rinse and oropharyngeal spray was found to be more effective than mouth rinse alone; cetylpyridinium chloride (CPC) did show promising results (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…In vitro studies have been done to test the action of H 2 O 2 against SARS‐CoV‐2 virus or just its S protein. 22 , 23 , 24 , 25 , 26 , 29 A corona surrogate, transmissible gastroenteritis virus (TGEV), was dried on stainless steel to H 2 O 2 vapour (20 µl) for 2–3 h and was seen that about 5log10 reduction in viral load. This study proved H 2 O 2 to have good surface decontamination ability, but concerns were on relative susceptibility of viruses in vivo and safety dosage when used as oral/nasal rinse.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Could mouth rinses be an adjuvant in the treatment of SARS‐CoV‐2 patients? An appraisal with a systematic review

Gandhi

Thimmappa

Upadhya

et al. 2021

Int J Dental Hygiene

View full text Add to dashboard Cite

Objective A wide variety of mouth rinses are available to combat micro‐organisms in the oral cavity. At the present global pandemic, the need of the hour is to control the viral infection due to the novel corona virus SARS‐COV‐2, as its port of entry is through the receptors located in the oral and pharyngeal mucosa. This systematic literature review focuses on the in vivo studies [randomized control trials (RCTs)] done on the efficacy of existing mouth rinses which have been used in reducing the viral loads. Methods The electronic database which includes PubMed‐MEDLINE, Google scholar, Scopus, Web of Science, EMBASE, ProQuest and CINAHL was searched from December 2019 to June 2021 with appropriate Medical Subject Headings (MeSH) terms and Boolean operators. Two reviewers independently reviewed the abstracts. Results Of the 2438 retrieved titles, 905 remained after removing duplicates. Twelve articles were eligible to be included in this review of which seven were randomized with adequate sample size. Conclusions Mouth washes containing povidone iodine and chlorhexidine decrease the viral load transiently. Large amount of in vivo studies are of paramount importance, especially RCTs, to prove the efficacy of these mouth rinses.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Could mouth rinses be an adjuvant in the treatment of SARS‐CoV‐2 patients? An appraisal with a systematic review

Gandhi

Thimmappa

Upadhya

et al. 2021

Int J Dental Hygiene

View full text Add to dashboard Cite

show abstract

“…In all clinical trials, a low number of participants were included, which decrease the clinical applicability of these findings. Other substances, such as povidone-iodine [ 63 ] and hydrogen peroxide [ 64 ], might be an additional benefit against SARS-CoV-2, but their clinical efficacy remains unproved [ 65 , 66 ]. It is noteworthy that the reduced timespan for the performance of large randomized clinical trials related to SARS-CoV-2, since it has been identified recently, could explain the scarcity of the literature.…”

Section: Discussionmentioning

confidence: 99%

Virucidal efficacy of chlorhexidine: a systematic review

et al. 2021

View full text Add to dashboard Cite

This study aimed to systematically review the literature about the virucidal efficacy of CHX in comparison to other substances used in the oral cavity. Electronic searches were performed in four databases (PubMed, Scopus, Embase, and Web of Science). Only studies that presented the following characteristics were included: (1) verified virucidal efficacy of CHX against Herpes Simplex Type-1 (HSV-1), any Influenza, or any human coronavirus (HcoV); and (2) compared the virucidal efficacy of CHX with essential oils (Listerine ® ), quaternary ammonium compounds, povidone-iodine, hydrogen peroxide, negative control substance, and absence of therapy. Two researchers independently selected the studies, extracted data and evaluated the risk of bias. A narrative data synthesis was used. Twenty-five studies were included, of which 21 were in vitro and four were randomized clinical trials (RCT). Studies assessed the virucidal efficacy of CHX against Herpes Simplex Type-1 (HSV-1) (10 studies), Influenza A (InfluA) (4 studies), human coronavirus (HCoV) (4 studies) and Severe Acute Respiratory Syndrome-Related Coronavirus (SARS-CoV-2) (11 studies). Most studies demonstrated that CHX has a positive virucidal efficacy against HSV-1 and InfluA strains. However, lower efficacy was shown to InfluA strain in comparison to povidone-iodine. Lower to none virucidal efficacy of CHX is expected for HCoV and SARS-CoV-2 strains for in vitro studies. Three RCT demonstrated that CHX was able to significantly reduce the viral load of SARS-CoV-2 for a short period. CHX may present an interesting virucidal efficacy against HSV-1 and InfluA viruses. CHX also presents transient efficacy against SARS-CoV-2 when used as a mouthwash.

show abstract

Green synthesis of silver nanoparticles using the extract of spent coffee used for paper-based hydrogen peroxide sensing device

Srikhao

Ounkaew

Kasemsiri

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Hydrogen peroxide (H2O2) has attracted considerable attention for use as a disinfectant ingredient for various applications over the decades. The use of H2O2 within the safety regulations can avoid its toxicity to human health and the environment. In this study, a paper-based sensor containing green-synthesized silver nanoparticles (P-AgNPs) was developed for use in a smartphone in the determination of the H2O2 concentration. In the synthesis process, an extract of spent coffee grounds was used as a bioreducing agent. The effects of reaction time and silver nitrate (AgNO3) concentration on the green synthesis of silver nanoparticles (AgNPs) were investigated. The optimum conditions for the preparation of P-AgNPs were determined to be 100 mM AgNO3 (P-AgNPs-100) and 15 h synthesis time. The P-AgNPs-100 sensor exhibited high sensitivity with a detection limit of 1.26 mM H2O2, which might be suitable for the detection of H2O2-based household and beverage sanitizers. The H2O2 detection capability of P-AgNPs-100 was comparable to that of a commercial strip sensor. Furthermore, P-AgNPs-100 had a detection efficiency of more than 95% after long-term storage for 100 days.

show abstract

Virucidal potential of H₂O₂‐based spray against SARS‐CoV‐2 and biosafety in a dental environment

Cited by 3 publications

References 12 publications

Could mouth rinses be an adjuvant in the treatment of SARS‐CoV‐2 patients? An appraisal with a systematic review

Could mouth rinses be an adjuvant in the treatment of SARS‐CoV‐2 patients? An appraisal with a systematic review

Virucidal efficacy of chlorhexidine: a systematic review

Green synthesis of silver nanoparticles using the extract of spent coffee used for paper-based hydrogen peroxide sensing device

Contact Info

Product

Resources

About

Virucidal potential of H2O2‐based spray against SARS‐CoV‐2 and biosafety in a dental environment

Cited by 3 publications

References 12 publications

Could mouth rinses be an adjuvant in the treatment of SARS‐CoV‐2 patients? An appraisal with a systematic review

Could mouth rinses be an adjuvant in the treatment of SARS‐CoV‐2 patients? An appraisal with a systematic review

Virucidal efficacy of chlorhexidine: a systematic review

Green synthesis of silver nanoparticles using the extract of spent coffee used for paper-based hydrogen peroxide sensing device

Contact Info

Product

Resources

About

Virucidal potential of H₂O₂‐based spray against SARS‐CoV‐2 and biosafety in a dental environment