Virulence and Pathogenicity of Fungal Pathogens with Special Reference to Candida albicans

Khan, Mohd Sajjad Ahmad; Ahmad, Iqbal; Aqil, Farrukh; Owais, M.; Shahid, Mohd; Musarrat, Javed

doi:10.1007/978-3-642-12173-9_2

Cited by 50 publications

(50 citation statements)

References 95 publications

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“…Candida is a gut commensal organism, and total parenteral nutritional support for short bowel syndrome with associated functional immunosuppression may have contributed to this patient's risk of fungal infection 2. As in this case, if a presumed bacterial or mycobacterial meningitis does not respond adequately to appropriate therapy, clinicians should consider a fungal cause.…”

Section: Discussionmentioning

confidence: 92%

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Intradural extramedullary spinal candida infection

et al. 2015

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Section: Discussionmentioning

confidence: 92%

“…Candida gains access to the vascular system via intravenous lines (most common), urinary catheters, from implanted prosthetic devices, or during surgery (particularly abdominal) 2 3 7. Intravascular fungal infection within the vascular supply to the nervous system may cause thrombosis and subsequent brain or cord infarction 3 4.…”

Section: Discussionmentioning

confidence: 99%

Intradural extramedullary spinal candida infection

et al. 2015

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“…[8][9][10][11] Jamur yang terdapat pada rendaman kadaver tentu saja seiring dengan perjalanan waktu akan merusak kualitas dari kadaver itu sendiri, dan yang paling berbahaya dapat menyebabkan penyakit pada individu yang bekerja maupun belajar di laboratorium anatomi, khususnya bila terjadi kondisi imunosupresi. 12,13 Beberapa contoh penyakit yang cukup berbahaya yang dapat disebabkan oleh infeksi jamur adalah pneumonia, selain infeksi pada kulit atau jaringan tubuh lainnya. Oleh karena itu, dibutuhkan upaya proteksi diri sebelum melakukan kontak dengan kadaver yaitu dengan menggunakan masker dan sarung tangan pelindung.…”

Section: -8unclassified

Fungi Identification in Preservative Liquids of Cadaver at Anatomy Laboratory of Faculty of Medicine Maranatha Christian University Bandung

Herdiman¹,

Winata²,

Pramesti³

et al. 2018

Journal of Medicine and Health

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Cadaver is an important learning media for students of the Faculty of Medicine. Although the cadaver has undergone a preservation process, sometimes the preservative liquids used only protects the cadaver, and does not inhibit the fungal growth. Based on previous research, the fungus found in cadaveric preparations are pathogenic. The objectives of this study were to identify the growing fungus on the cadaver preservative liquid at the Anatomy Laboratory of the Faculty of Medicine, Maranatha Christian University. This is a descriptive experimental study. Samples were taken from three cadaver tubs. Subsequently, the sample was inoculated on Sabouraud's Dextrose Agar and Chromagar medium in a petridish and incubated at room temperature (25⁰) for seven days. After seven days, the morphology of the fungus was observed AbstrakKadaver merupakan media pembelajaran yang penting bagi mahasiswa fakultas kedokteran. Meskipun kadaver telah mengalami proses pengawetan, terkadang formula cairan pengawet yang digunakan hanya mampu menjaga kadaver bertahan lama tanpa menghambat pertumbuhan jamur. Berdasarkan penelitian sebelumnya, jamur yang ditemukan pada sediaan kadaver merupakan jamur patogen yang menimbulkan penyakit. Tujuan penelitian ini adalah untuk mengidentifikasi jamur yang tumbuh pada sediaan kadaver di Laboratorium Anatomi Fakultas Kedokteran Universitas Kristen Maranatha. Desain penelitian menggunakan desain eksperimental deskriptif. Sampel diambil dari masing-masing bak rendaman kadaver. Selanjutnya, sampel diinokulasi pada medium Sabouraud's Dextrose Agar dan Chromagar di dalam cawan petri dan diinkubasi pada suhu ruangan (25⁰ C) selama tujuh hari. Setelah tujuh hari, morfologi jamur diamati secara makroskopis dan mikroskopis. Dari hasil pengamatan, didapatkan beberapa jenis jamur dari biakkan sampel yaitu Aspergillus sp., Penicillium sp., Epidermophyton sp., dan Candida sp. Penelitian ini dilakukan pada bulan Desember 2017-Januari 2018 di Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Kristen Maranatha dan Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Padjajaran. Kata kunci: jamur, kadaver, cairan pengawetJournal of Medicine and Health Fungi Identification in Preservative ... Vol.2 No.1 February 2018 Research Article 674 PendahuluanKadaver digunakan untuk mempelajari anatomi manusia secara nyata dan dalam bentuk tiga dimensi. Mahasiswa dapat mempelajari bagian tubuh manusia dari bagian luar sampai dalam, seperti pembuluh darah, saraf, otot, dan organ dalamnya. Pemahaman anatomi menggunakan kadaver tetap tidak dapat digantikan dengan metoda pembelajaran lainnya karena dengan kadaver, anatomi manusia menjadi lebih nyata. 1 Salah satu masalah yang sering timbul pada rendaman kadaver di laboratorium anatomi antara lain tumbuhnya mikroorganisme yang tidak diinginkan, salah satunya adalah jamur. Meskipun kadaver telah mengalami proses pengawetan, terkadang formula cairan pengawet yang digunakan hanya mampu menjaga jaringan kadaver bertahan lama tanpa menghambat pertumbuhan jamur. ...

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“…144 Moreover, Candida pathogens secrete aspartyl proteinases (SAPs), which are critical molecules that allow them to degrade barrier tissues by hydrolysing proteins such as collagen, fibronectin and keratin in order to obtain nutrition at the site of the infection. 87 In addition, the secretion of SAP4 and SAP6 from Candida is necessary for the activation of systemic Toll-dependent immunity. 144 Although Toll pathway controls fungal infection with both C. albicans and C. glabrata, the two species differ in their ability to activate protective melanization.…”

Section: Aspergillus Fumigatusmentioning

confidence: 99%

Human pathogenic bacteria, fungi, and viruses inDrosophila

2014

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Drosophila has been the invertebrate model organism of choice for the study of innate immune responses during the past few decades. Many Drosophila-microbe interaction studies have helped to define innate immunity pathways, and significant effort has been made lately to decipher mechanisms of microbial pathogenesis. Here we catalog 68 bacterial, fungal, and viral species studied in flies, 43 of which are relevant to human health. We discuss studies of human pathogens in flies revealing not only the elicitation and avoidance of immune response but also mechanisms of tolerance, host tissue homeostasis, regeneration, and predisposition to cancer. Prominent among those is the emerging pattern of intestinal regeneration as a defense response induced by pathogenic and innocuous bacteria. Immunopathology mechanisms and many microbial virulence factors have been elucidated, but their relevance to human health conventionally necessitates validation in mammalian models of infection.

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Virulence and Pathogenicity of Fungal Pathogens with Special Reference to Candida albicans

Cited by 50 publications

References 95 publications

Intradural extramedullary spinal candida infection

Intradural extramedullary spinal candida infection

Fungi Identification in Preservative Liquids of Cadaver at Anatomy Laboratory of Faculty of Medicine Maranatha Christian University Bandung

Human pathogenic bacteria, fungi, and viruses inDrosophila

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