2023
DOI: 10.1128/cmr.00148-22
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Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages

Jhih-Hang Jiang,
David R. Cameron,
Cara Nethercott
et al.

Abstract: SUMMARY Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful lineage has been replaced by a more fit and better adapted lineage. Selection pressures in both hospital and community settings are not uniform across the globe, which has resulted in geographically distinct epidemiology. This review focuses on the mechanisms that trigger the esta… Show more

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Cited by 7 publications
(1 citation statement)
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“…For example, the diphtheria toxin produced by Corynebacterium diphtheriae binds to host cells and inhibits protein synthesis, leading directly to cell death [33,34]. The α-toxin produced by Staphylococcus aureus (S. aureus) can form pores in host cell membranes, leading to cell lysis and tissue damage [35,36]. Moreover, they can also deprive cells of nutrients and cause cell death.…”
Section: Pathological Features Of Idsmentioning
confidence: 99%
“…For example, the diphtheria toxin produced by Corynebacterium diphtheriae binds to host cells and inhibits protein synthesis, leading directly to cell death [33,34]. The α-toxin produced by Staphylococcus aureus (S. aureus) can form pores in host cell membranes, leading to cell lysis and tissue damage [35,36]. Moreover, they can also deprive cells of nutrients and cause cell death.…”
Section: Pathological Features Of Idsmentioning
confidence: 99%