Virulence Factors and Antibiotic Resistance in Children With <i>Helicobacter pylori</i> Gastritis

Karabi̇ber, Hamza; Selimoğlu, Mukadder Ayşe; Otlu, Barış; Yıldırım, Oğuzhan; Özer, Ali

doi:10.1097/mpg.0000000000000273

Cited by 38 publications

(28 citation statements)

References 35 publications

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“…The use of antibiotics for infections like gynecological, parasitic, or upper respiratory infections is considered a major risk factor for the development of resistance [50]. Changes in resistance profile over time may be caused by increased clarithromycin usage for pneumonia and decreased metronidazole usage for diarrhea because of a gradual increase in hygienic conditions nationwide [30]. Macrolide consumption is a significant problem in increasing clarithromycin resistance in H. pylori isolates.…”

Section: Discussionmentioning

confidence: 99%

“…In another southern region study, the clarithromycin resistance rate was found to be smaller at 8.9%, but the patients were living in rural areas with no history of macrolide use [28]. In two eastern region studies, the primary clarithromycin resistance rates were detected as 16.4 and 23.5% in 2008 and 2014, respectively [29,30]. The 2014 study included children who were 2 to 17 years old, and there was an increase in the primary clarithromycin resistance rates reported from the east region of Turkey [30].…”

Section: Prevalence Of Primary Clarithromycin Resistancementioning

confidence: 99%

“…In two eastern region studies, the primary clarithromycin resistance rates were detected as 16.4 and 23.5% in 2008 and 2014, respectively [29,30]. The 2014 study included children who were 2 to 17 years old, and there was an increase in the primary clarithromycin resistance rates reported from the east region of Turkey [30].…”

Section: Prevalence Of Primary Clarithromycin Resistancementioning

confidence: 99%

“…In this study, the overall resistance of H. pylori to amoxicillin was detected in 3 (0.9%, 95% CI: 0.2-2.5) of 1059 total H. pylori strains isolated in Turkey. The primary amoxicillin resistance was not detected in two studies from the central region and one from the south, but it was detected as 3.2% and 3.9% in one of three west region studies (the 2012 study) and one eastern study [11,19,22,24,26,27,30]. On the other hand, the overall resistance of H. pylori to tetracycline was detected in two (3.5%, 95% CI: 1.5-6.7%) of 1059 total H. pylori strains isolated in Turkey.…”

Section: Prevalence Of Primary Amoxicillin and Tetracycline Resistancementioning

confidence: 99%

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Prevalence of Primary Antimicrobial Resistance of H. pylori in Turkey: A Systematic Review

Kocazeybek

Tokman

2015

Helicobacter

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Primary antibiotic resistance against H. pylori in Turkey shows differences between geographical regions and population densities. There is an increase in primary resistance rates to clarithromycin and metronidazole in different years. The data are not sufficient for tetracycline, amoxicillin, and levofloxacin. High clarithromycin resistance rates were mostly detected in overpopulated cities like Ankara (north), Izmir (west), Istanbul (west), and Bursa (west).

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Section: Discussionmentioning

confidence: 99%

Section: Prevalence Of Primary Clarithromycin Resistancementioning

confidence: 99%

Section: Prevalence Of Primary Clarithromycin Resistancementioning

confidence: 99%

Section: Prevalence Of Primary Amoxicillin and Tetracycline Resistancementioning

confidence: 99%

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Prevalence of Primary Antimicrobial Resistance of H. pylori in Turkey: A Systematic Review

Kocazeybek

Tokman

2015

Helicobacter

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“…18 . In 2014, 89 children were included in another study from a different part of Turkey and clarithromycin resistance was found to be 23.5% 19 . Factors such as the use of different methods, different ratios in using antibiotics for regions and the experience of people applying the method can be effective in identifying different resistant ratios in studies 20 .…”

Section: Discussionmentioning

confidence: 99%

Clarithromycin resistance and 23S rRNA gene point mutations of Helicobacter pylori infection in children

et al. 2016

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This study aims to evaluate Helicobacter pylori with clarithromycin resistant genotypes in Manisa region, Turkey. Two hundred patients, who received diagnosis of Helicobacter pylori infection histopathologically, were included. The sex, age and endoscopy indications of the patients were recorded. Polymerase chain reaction method was applied to determine the clarithromycin resistance rate and resistance genotypes at the histologic sections prepared from gastric biopsies that had been embedded in paraffin after fixation by formalin. Helicobacter pylori resistance to clarithromycin was found in 19/200 (9.5%) patients. 10/19 (52.6%) of these clarithromycin-resistant patients had A2143G mutation and 9/19 (47.4%) had A2142G mutation. A2142C mutation on 23S rRNA gene was not detected for any of the patients. Clarithromycin can be used as a first step treatment in the eradication of Helicobacter pylori for the children in our region; if the treatment fails for some patients, clarithromycin resistance, especially A2143G and A2142G mutations should be considered.

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Factors associated with Helicobacter pylori antimicrobial resistance in a US pediatric cohort

Riaz,

Chan,

Andrews

et al. 2024

J. pediatr. gastroenterol. nutr.

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ObjectivesThe rising rates of Helicobacter pylori antimicrobial resistance highlight the importance of better understanding its epidemiology in the pediatric population. We aim to study the epidemiological factors associated with antimicrobial resistance in a cohort of US children with H. pylori infection.MethodsA retrospective cohort study of patients in the New England region of the United States between January 15, 2015 and October 15, 2022, with a first‐time diagnosis of H. pylori on gastric biopsy and who had antimicrobial resistance data available. Descriptive statistics and logistic regression models were used to determine associations between the patient's demographics, clinical factors, endoscopic findings, and antimicrobial resistance.ResultsOut of 273 patients (46% male, median 12.8 years), 118 (43.2%) were resistant to at least one antimicrobial. Clarithromycin resistance (24.5%) was the highest, followed by metronidazole (21.6%), fluoroquinolones (9.9%), rifabutin (3.3%), and amoxicillin (2.6%). Clarithromycin resistance was higher in Asians compared to white individuals (odds ratio [OR]: 4.68, 95% confidence interval [CI]: [2.01–10.89], p < 0.001), and lower in black compared to white individuals (OR: 0.23, 95% CI: [0.08–0.69], p = 0.01). Antimicrobial resistance to clarithromycin and metronidazole were similar among Hispanics. Asian individuals were more likely to demonstrate one or more antimicrobial resistances compared to whites (OR: 3.66, 95% CI: [1.50–8.89], p < 0.001). Compared to individuals from higher household incomes (>$100,000), those from less than $30,000 household incomes had a higher risk of metronidazole resistance (OR: 7.94, 95% CI: [1.83–34.36], p = 0.01).ConclusionOur study provides novel information concerning the association of H. pylori antimicrobial resistance to race, socioeconomic status, and age in the pediatric population.

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Virulence Factors and Antibiotic Resistance in Children With Helicobacter pylori Gastritis

Cited by 38 publications

References 35 publications

Prevalence of Primary Antimicrobial Resistance of H. pylori in Turkey: A Systematic Review

Prevalence of Primary Antimicrobial Resistance of H. pylori in Turkey: A Systematic Review

Clarithromycin resistance and 23S rRNA gene point mutations of Helicobacter pylori infection in children

Factors associated with Helicobacter pylori antimicrobial resistance in a US pediatric cohort

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