Virulence Markers of Streptococcus suis Type 1 and 2

Smith, Hilde E.; Wisselink, Henk J.; Stockhofe-Zurwieden, Norbert; Vecht, U.; Smits, Mari M.

doi:10.1007/978-1-4899-1825-3_152

Cited by 31 publications

(29 citation statements)

References 6 publications

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“…One sequence, iri-31, was identical to cps2A, a previously identified Strep. suis gene putatively involved in the regulation of capsule expression (Smith et al, 1999). Fourteen iri sequences were similar to sequences of known, non-Strep.…”

Section: Selection Of Promoters Induced Under Iron-restricted Conditionsmentioning

confidence: 80%

“…suis, ivs-23 and 24 and iri-24 are not linked to the capsular locus (Smith et al, 1999). The oxyR gene is the central regulator of oxidative stress response in E. coli (Demple, 1999) These genes also showed similarity to ivi genes selected using IVET in other bacterial species.…”

Section: Discussionmentioning

confidence: 94%

“…This gene was previously isolated as a part of the capsular locus of Strep. suis serotype 2 (Smith et al, 1999) and was implicated in the regulation of capsular polysaccharide biosynthesis (Kolkman et al, 1997 ;Smith et al, 1999). Moreover, because the size of the capsule of Strep.…”

Section: Discussionmentioning

confidence: 99%

“…nos AF106927, Z95920 and A57222) and of these, only a few are putatively involved in virulence (Smith et al, , 1993(Smith et al, , 1999Jacobs et al, 1994 ;Gottschalk et al, 1995 ;Segers et al, 1998). Previously, putative virulence factors have been identified after growth of bacteria in standard laboratory media.…”

Section: Abbreviation : Ivet In Vivo Expression Technologymentioning

confidence: 99%

“…At present, however, only a limited number of Strep. suis genes are known (Smith et al, , 1993(Smith et al, , 1999Serhir et al, 1997 ;Segers et al, 1998 ;and GenBank accession …”

Section: Introductionmentioning

confidence: 99%

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Environmentally regulated genes of Streptococcus suis: identification by the use of iron-restricted conditions in vitro and by experimental infection of piglets The GenBank accession numbers for the sequences determined in this work are AF302190–AF302207 (iri genes) and AF303226–303247 (ivs genes).

Smith¹,

Buijs²,

Vries³

et al. 2001

Microbiology

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The identification of environmentally regulated genes of Streptococcus suis by the use of iron-restricted conditions in vitro and by experimental infection of piglets is described. Eighteen unique iron-restriction-induced (iri) genes and 22 unique in-vivo-selected (ivs) genes of Strep. suis were found. None of the ivs genes was exclusively expressed in vivo. Four iri genes were identical to four clones selected in piglets. Two ivs genes were similar to genes for putative virulence factors. One of these ivs genes was identical to the epf gene of virulent Strep. suis serotype 2 strains and the other showed homology to a gene encoding a fibronectin-binding protein of Streptococcus gordonii. Two additional ivs genes showed homology to environmentally regulated genes previously identified by using an in vivo expression technology (IVET) selection system in other bacterial species. One of these showed similarity to the agrA gene of Staphylococcus aureus, a key locus involved in the regulation of numerous virulence proteins. The promoter selection system described in this paper has been successfully used for the identification of many environmentally regulated genes potentially involved in the pathogenesis of Strep. suis infections in piglets.

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Section: Selection Of Promoters Induced Under Iron-restricted Conditionsmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Abbreviation : Ivet In Vivo Expression Technologymentioning

confidence: 99%

“…At present, however, only a limited number of Strep. suis genes are known (Smith et al, , 1993(Smith et al, , 1999Serhir et al, 1997 ;Segers et al, 1998 ;and GenBank accession …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Environmentally regulated genes of Streptococcus suis: identification by the use of iron-restricted conditions in vitro and by experimental infection of piglets The GenBank accession numbers for the sequences determined in this work are AF302190–AF302207 (iri genes) and AF303226–303247 (ivs genes).

Smith¹,

Buijs²,

Vries³

et al. 2001

Microbiology

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Streptococcosis

Gottschalk¹,

Segura²

2019

Diseases of Swine

116

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Characterization of Streptococcus suis Isolates from Slaughter Swine

Wang

Zhang

et al. 2012

Curr Microbiol

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The characterization of 61 Streptococcus suis strains isolated from Chinese slaughter pigs was investigated. S. suis serotypes 1, 2, 3, 4, 7, 9, 10, 11, 12, 13, 14, 15, 16, 22, 23, 25, 26, 28, 29, and 1/2 were found in the isolates by serum agglutination. Of all the prevalent serotypes, S. suis serotype 7 is the most predominant circulating in Chinese slaughter pigs. The virulence-associated genes profile and multilocus sequence typing scheme of the isolates were analyzed. The mrp-/epf-/sly- virulence-associated genes type is the most prevalent in the isolates from slaughter pigs. It is the first time to find S. suis serotypes 7 and 9 isolates with epf. The serotypes 7 and 9 isolates with mrp and/or epf genes did not express MRP and/or EF in the present research. Thirteen new ST types were identified for the first time. ST1 complex and ST27 complex of S. suis are prevalent in China. This paper supplied information to understand the characteristics, such as capsular serotypes, virulence factors, and gene backgrounds of S. suis carried by slaughter pigs.

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Virulence Markers of Streptococcus suis Type 1 and 2

Cited by 31 publications

References 6 publications

Streptococcosis

Characterization of Streptococcus suis Isolates from Slaughter Swine

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