Virulence traits and expression of bstA, fliC and sopE2 in Salmonella Dublin strains isolated from humans and animals in Brazil

Vilela, Felipe Pinheiro; Gomes, Carolina Nogueira; Paziani, Mário Henrique; Braz, Vânia Santos; Rodrigues, Dália dos Prazeres; Costa, Renata Garcia; Tiba‐Casas, Monique Ribeiro; Kress, Márcia Regina von Zeska; Falcão, Juliana Pfrimer; Campioni, Fábio

doi:10.1016/j.meegid.2020.104193

Cited by 10 publications

(3 citation statements)

References 50 publications

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“… 2020 ; Vilela et al . 2020 ). Human pathogens can be injected into G. mellonella hemocel together with new antibacterial, antiviral or antifungal drugs to compare their survival with that in an infected group injected with a placebo instead of the drug, or to test mutual interactions between drugs.…”

Section: G Mellonella As An Insect Model Organism For Immunmentioning

confidence: 99%

The greater wax mothGalleria mellonella: biology and use in immune studies

Wojda

Staniec

Sułek

et al. 2020

Pathogens and Disease

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The greater wax moth Galleria mellonella is an invertebrate, which is increasingly being used in scientific research. Its ease of reproduction, numerous offspring, short development cycle, and, finally, its known genome and immune-related transcriptome provide a convenient research model for investigation of insect immunity at the biochemical and molecular levels. Galleria immunity, consisting of only innate mechanisms, shows adaptive plasticity, which has recently become the subject of intensive scientific research. This insect serves as a mini host in studies of the pathogenicity of microorganisms and in vivo tests of the effectiveness of single virulence factors as well as new antimicrobial compounds. Certainly, the Galleria mellonella species deserves our attention and appreciation for its contribution to the development of research on innate immune mechanisms. In this review article, we describe the biology of the greater wax moth, summarize the main advantages of using it as a model organism, and present some main techniques facilitating work with this animal.

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Section: G Mellonella As An Insect Model Organism For Immunmentioning

confidence: 99%

The greater wax mothGalleria mellonella: biology and use in immune studies

Wojda

Staniec

Sułek

et al. 2020

Pathogens and Disease

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“…We previously undertook a genomic investigation of another emerging NTS lineage in Australia, Salmonella enterica serovar 4, [5],12:i:-, and identified several bacterial traits that may have contributed to the successful spread of this lineage (25)(26)(27)(28)(29). In particular, we hypothesised that flagellin deletion and MDR status may have contributed to host immune evasion and positive selection, respectively, in Salmonella enterica serovar 4, [5],12:i:- (30).…”

Section: Introductionmentioning

confidence: 99%

Dynamics of antimicrobial resistance and virulence ofSalmonella entericaserovar Dublin

Sia,

Ambrose,

Valcanis

et al. 2024

Preprint

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Salmonella Dublin is a host-adapted, invasive non-typhoidal Salmonella (iNTS) serovar that causes bloodstream infections in humans and demonstrates increasing prevalence of antimicrobial resistance (AMR). Here, we characterised a global population of 1,303 S. Dublin isolates for resistance and virulence mechanisms using a combined approach of in silico and in vitro analyses. We observed distinct populations of Vi antigen-negative S. Dublin circulating in different geographical regions, with the emergence of a North American cluster ~60 years ago. Further, we identified two distinct lineages in Australia, within which we discovered a novel hybrid plasmid encoding both AMR and mercuric resistance, highlighting the potential for emerging virulent and resistant lineages. These differences, in addition to the lack of Vi flagella represent adaptation mechanisms that may enhance survival and pathogenicity, and in turn affect prevention and control strategies for future S. Dublin infections. Collectively, our study embodies one of the most comprehensive investigations of S. Dublin and highlights the potential impact of pathogen adaptation on global health and economic burdens experienced by different sectors including livestock and human health.

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“…Na literatura pode-se observar a utilização desse modelo alternativo de infecção em diferentes estudos com Salmonela spp. (FREITAS et al, 2021;SERIBELLI et al, 2020;SILVA et al, 2021;VILELA et al, 2020;). PROROGA et al, 2019;QIN et al, 2022;SUN et al, 2020a).…”

Section: Galleria Mellonellaunclassified

Caracterização molecular e fenotípica de linhagens de Salmonella 1,4, [5],12:i:- isoladas predominantemente no Estado de São Paulo entre 1983 e 2020

Pereira

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AGRADECIMENTOSA Deus, por abençoar e iluminar o meu caminho durante todo o desenvolvimento deste trabalho, onde sempre houve esperança, amor e fé no meu coração. À minha família, em especial aos meus pais, Jaime e Liromar, por todo amor e carinho, por sempre me apoiarem, por me permitirem seguir meus sonhos, por me incentivarem e por entenderem a minha ausência em muitos momentos. Vocês são tudo para mim.À minha orientadora, Profa. Dra. Juliana Pfrimer Falcão, por ter sido tão acolhedora desde o primeiro contato, pela oportunidade, pelos ensinamentos, pelo carinho e pela confiança no meu trabalho. Sou muito grata por ser sua aluna.

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Virulence traits and expression of bstA, fliC and sopE2 in Salmonella Dublin strains isolated from humans and animals in Brazil

Cited by 10 publications

References 50 publications

The greater wax mothGalleria mellonella: biology and use in immune studies

The greater wax mothGalleria mellonella: biology and use in immune studies

Dynamics of antimicrobial resistance and virulence ofSalmonella entericaserovar Dublin

Caracterização molecular e fenotípica de linhagens de Salmonella 1,4, [5],12:i:- isoladas predominantemente no Estado de São Paulo entre 1983 e 2020

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