Virulent potential of methicillin-resistant and methicillin-susceptible Staphylococcus pseudintermedius in dogs

Breyer, Gabriela Merker; Saggin, Bianca Fagundes; Carli, Sílvia De; Silva, Maria Eduarda Rocha Jacques da; Costa, Mateus Matiuzzi da; Brenig, Bertram; Azevedo, Vasco; Cardoso, Marisa Ribeiro de Itapema; Siqueira, Franciele Maboni

doi:10.1016/j.actatropica.2023.106911

Cited by 7 publications

(1 citation statement)

References 49 publications

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“…Other toxin genes found in the S. pseudintermedius genome include a bicomponent leukocidin LukI [224], which targets polymorphonuclear white blood cells from canine origin [48], a beta-hemolysin [225] and enterotoxin SEC CANINE , which acts as a superantigen [169]. Further enterotoxin genes have been identified by analytical PCR and by whole genome sequencing in S. pseudintermedius [226,227].…”

Section: Staphylococcal Pathogens In Dogs and Catsmentioning

confidence: 99%

Virulence Mechanisms of Staphylococcal Animal Pathogens

Cheung,

Otto

2023

IJMS

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Staphylococci are major causes of infections in mammals. Mammals are colonized by diverse staphylococcal species, often with moderate to strong host specificity, and colonization is a common source of infection. Staphylococcal infections of animals not only are of major importance for animal well-being but have considerable economic consequences, such as in the case of staphylococcal mastitis, which costs billions of dollars annually. Furthermore, pet animals can be temporary carriers of strains infectious to humans. Moreover, antimicrobial resistance is a great concern in livestock infections, as there is considerable antibiotic overuse, and resistant strains can be transferred to humans. With the number of working antibiotics continuously becoming smaller due to the concomitant spread of resistant strains, alternative approaches, such as anti-virulence, are increasingly being investigated to treat staphylococcal infections. For this, understanding the virulence mechanisms of animal staphylococcal pathogens is crucial. While many virulence factors have similar functions in humans as animals, there are increasingly frequent reports of host-specific virulence factors and mechanisms. Furthermore, we are only beginning to understand virulence mechanisms in animal-specific staphylococcal pathogens. This review gives an overview of animal infections caused by staphylococci and our knowledge about the virulence mechanisms involved.

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