Virus del herpes humano tipo 6 y tipo 7 en receptores de trasplantes

Benito, Natividad; Moreno, Asunción; Pumarola, Tomás; Marcos, María Ángeles

doi:10.1016/s0213-005x(03)72980-2

Cited by 14 publications

(13 citation statements)

References 91 publications

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“…In vitro, foscarnet ha mostrado ser más eficaz que el aciclovir o el ganciclovir. La disminución de la inmunosupresión se asocia con una menor actividad replicativa del virus 114,115 . Aunque no existen datos suficientes, el ganciclovir a dosis profiláctica probablemente no sea eficaz para prevenir la reactivación de este virus.…”

Section: Virus Del Herpes Humano Tipounclassified

Infecciones más comunes en el paciente trasplantado

Yuste

Pozo

Quetglas

et al. 2006

Anales Sis San Navarra

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Organ transplantation has become one of the most important areas of medical research and, at present, is still the only therapeutical tool for several diseases. However, there are a number of factors related to transplantation, like immunosuppression and prolonged neutropenia that affect the incidence of infection. These infections are somehow peculiar to trasplant recipients. In fact, there are infectious diseases that only occur in immunodepression situations and, moreover, clinical expression of these infectious diseases can be quite different from that in immunocompetent patients. Besides these aspects, some infections, due to the high prevalence described, must be considered for prevention strategies because they continue to be a principal cause of morbidity and mortality, either due to direct effects or to their implication in the pathogenesis of rejection. These strategies commence before trasplantation by active immunization through vaccine administration to the patient and to people in the milieu and continue after trasplantation with prophylaxis or pre-emptive therapy. The importance of infectious diseases in the evolution and prognosis of trasplant recipients gives a special meaning to the understanding of associated infections, their clinical expression and ways of prevention and treatment.

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Section: Virus Del Herpes Humano Tipounclassified

Infecciones más comunes en el paciente trasplantado

Yuste

Pozo

Quetglas

et al. 2006

Anales Sis San Navarra

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“…Physical and neurological examinations were otherwise unremarkable. The white-cell count was 9100 per cubic millimeter (mm 3 ), hemoglobin concentration 10.5 mg/dL, hematocrit 30%, and platelet count 14 5000 per mm 3 ; liver dysfunction was found, with an increase in the levels of aspartat aminotransferase (AST; 122 UI/L), alanine aminotransferase (ALT; 222 UI/L), gamma-glutamyl transpeptidase (GGT; 92 UI/L), and alkaline phosphatase (AP; 317 UI/L). Plasma glucose was 91 mg/dL and creatinine was 1.5 mg/dL.…”

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confidence: 99%

“…On the fifth hospital day (day 22 post-transplant), the patient developed a transient cutaneous rash consisting of tenuous erythematous macules located predominantly on the trunk and that could be observed during 48 h. Leucopenia worsened (1200 leucocytes/mm 3 ) and confusion with regard to time and place appeared. Analysis of a cerebrospinal fluid (CSF) sample demonstrated 10 white cells/mm 3 , a glucose level of 75 mg/dL, and a protein level of 52 mg/dL.…”

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confidence: 99%

“…Analysis of a cerebrospinal fluid (CSF) sample demonstrated 10 white cells/mm 3 , a glucose level of 75 mg/dL, and a protein level of 52 mg/dL. Acid-fast smears and Gram stain were negative.…”

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confidence: 99%

“…However, on day 11, the white-cell count declined to 100 leucocytes/mm 3 , and anemia (hemoglobin of 7 g/dL) appeared. Subcutaneous administration of recombinant human granulocyte-colony stimulating factor (G-CSF) was started.…”

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confidence: 99%

See 2 more Smart Citations

Infection with Human Herpesvirus 6 after Kidney-Pancreas Transplant

Benito

Ricart

Pumarola

et al. 2004

American Journal of Transplantation

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IgG subclasses and DNA detection of HHV‐6 and HHV‐7 in healthy individuals

Biganzoli

Ferreyra

Sicilia

et al. 2010

Journal of Medical Virology

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Human herpesvirus 6 (HHV-6) and 7 (HHV-7) are common opportunistic agents in immunocompromised hosts, although infection with HHV-6 and HHV-7 can also be observed in immunocompetent hosts. Despite similar biology and epidemiology, this study evaluated differences in the IgG subclass distribution associated with HHV-6 and HHV-7 in seropositive, healthy persons. The identified subclasses were also compared with the detection of HHV-6 and HHV-7 DNA. For these assays, sera, plasma, and saliva samples were obtained from 40 healthy blood donors in Argentina who were seropositive for both HHV-6 and HHV-7. HHV-6 and HHV-7 DNA were detected in saliva and plasma samples using nested PCR, and specific IgG subclasses were determined using immunofluorescent assays of sera samples. HHV-7 DNA was detected in 90% of all plasma samples and in 100% of saliva samples. In contrast, HHV-6 DNA was not detected in any of the plasma samples, and it was detected in only 6 of 40 saliva samples. Determination of IgG subclass distributions showed that HHV-6 was restricted to IgG1, whereas HHV-7 IgG subclasses included two groups, one restricted only to IgG1 and the other to IgG1 and IgG3. These results demonstrate the differences between HHV-6 and HHV-7 DNA range detection in saliva and plasma samples, as well as the IgG subclass patterns for each virus type, in healthy persons in Argentina.

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Virus del herpes humano tipo 6 y tipo 7 en receptores de trasplantes

Cited by 14 publications

References 91 publications

Infecciones más comunes en el paciente trasplantado

Infecciones más comunes en el paciente trasplantado

Infection with Human Herpesvirus 6 after Kidney-Pancreas Transplant

IgG subclasses and DNA detection of HHV‐6 and HHV‐7 in healthy individuals

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