Virus-Incorporated Biomimetic Nanocomposites for Tissue Regeneration

Raja, Iruthayapandi Selestin; Kim, Chuntae; Song, Saemee; Shin, Yong Cheol; Kang, Moon Sung; Hyon, Suong‐Hyu; Oh, Jin‐Woo; Han, Dong‐Wook

doi:10.3390/nano9071014

Cited by 21 publications

(16 citation statements)

References 95 publications

(115 reference statements)

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“…As a consequence, many multidisciplinary studies on the assembly or disassembly of virus particles have been undertaken and have been reviewed. 4 − 10 Such experimental and theoretical studies are contributing to understanding supramolecular self-assembly and its relationship to biological function; 4 − 10 the development of antiviral drugs that inhibit or misdirect virus morphogenesis or genome uncoating; 11 , 12 the engineering of virus-like nanoparticles and nanomaterials for biomedical or nanotechnological applications; 13 − 16 and the design and fabrication using a bottom-up approach of other nanostructures that can self-assemble in one, two, or three dimensions. 17 − 20…”

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confidence: 99%

Visualization of Single Molecules Building a Viral Capsid Protein Lattice through Stochastic Pathways

et al. 2020

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Direct visualization of pathways followed by single molecules while they spontaneously self-assemble into supramolecular biological machines may provide fundamental knowledge to guide molecular therapeutics and the bottom-up design of nanomaterials and nanodevices. Here, high-speed atomic force microscopy is used to visualize self-assembly of the bidimensional lattice of protein molecules that constitutes the framework of the mature human immunodeficiency virus capsid. By real-time imaging of the assembly reaction, individual transient intermediates and reaction pathways followed by single molecules could be revealed. As when assembling a jigsaw puzzle, the capsid protein lattice is randomly built. Lattice patches grow independently from separate nucleation events whereby individual molecules follow different paths. Protein subunits can be added individually, while others form oligomers before joining a lattice or are occasionally removed from the latter. Direct real-time imaging of supramolecular self-assembly has revealed a complex, chaotic process involving multiple routes followed by individual molecules that are inaccessible to bulk (averaging) techniques.

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confidence: 99%

Visualization of Single Molecules Building a Viral Capsid Protein Lattice through Stochastic Pathways

et al. 2020

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“…The M13 bacteriophage is recently emerging as the functional material for multiple applications in energy harvesting [26][27][28], chemical sensor [29][30][31], and tissue regeneration [32,33]. It is a filamentous bacterial virus with the well-defined dimension of 880 nm in length and 6.6 nm in width, consisting of single-stranded DNA which is wrapped up with 2700 copies of major proteins (pVIII) and lidded with five copies of minor proteins (pIII/pVI or pVIII/pIX) on the top or bottom ends, respectively.…”

Section: Piezoelectric Proteinsmentioning

confidence: 99%

Recent Advances in Organic Piezoelectric Biomaterials for Energy and Biomedical Applications

2020

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The past decade has witnessed significant advances in medically implantable and wearable devices technologies as a promising personal healthcare platform. Organic piezoelectric biomaterials have attracted widespread attention as the functional materials in the biomedical devices due to their advantages of excellent biocompatibility and environmental friendliness. Biomedical devices featuring the biocompatible piezoelectric materials involve energy harvesting devices, sensors, and scaffolds for cell and tissue engineering. This paper offers a comprehensive review of the principles, properties, and applications of organic piezoelectric biomaterials. How to tackle issues relating to the better integration of the organic piezoelectric biomaterials into the biomedical devices is discussed. Further developments in biocompatible piezoelectric materials can spark a new age in the field of biomedical technologies.

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“…The most promising experiments combined selected scaffold, the application of tissue-specific therapeutic cells (i.e., stem cells), and bioactive molecules (e.g., cytokines and growth factors). The chosen sequences of polypeptides are used as a growth stimulant [ 158 ]. However, the cost of such therapy may be a massive obstacle.…”

Section: Bacteriophages In Materials Sciencementioning

confidence: 99%

Application of Bacteriophages in Nanotechnology

Paczesny

Bielec

2020

Nanomaterials

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Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single phage body virion, is a colloidal particle, often possessing a dipole moment. As such, phages were used as perfectly monodisperse systems to study various physicochemical phenomena (e.g., transport or sedimentation in complex fluids), or in the material science (e.g., as scaffolds). Nevertheless, phages also execute the life cycle to multiply and produce progeny virions. Upon completion of the life cycle of phages, the host cells are usually destroyed. Natural abilities to bind to and kill bacteria were a starting point for utilizing phages in phage therapies (i.e., medical treatments that use phages to fight bacterial infections) and for bacteria detection. Numerous applications of phages became possible thanks to phage display—a method connecting the phenotype and genotype, which allows for selecting specific peptides or proteins with affinity to a given target. Here, we review the application of bacteriophages in nanoscience, emphasizing bio-related applications, material science, soft matter research, and physical chemistry.

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Virus-Incorporated Biomimetic Nanocomposites for Tissue Regeneration

Cited by 21 publications

References 95 publications

Visualization of Single Molecules Building a Viral Capsid Protein Lattice through Stochastic Pathways

Visualization of Single Molecules Building a Viral Capsid Protein Lattice through Stochastic Pathways

Recent Advances in Organic Piezoelectric Biomaterials for Energy and Biomedical Applications

Application of Bacteriophages in Nanotechnology

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