Virus-induced airway hyperresponsiveness in the guinea pig can be transferred by bronchoalveolar cells

Folkerts, Gert; Verheyen, A.; Janssen, Marc; Nijkamp, Frans P.

doi:10.1016/s0091-6749(05)80016-8

Cited by 19 publications

(6 citation statements)

References 30 publications

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“…In our laboratory supporting evidence was found that inflammatory cells can modify airway responsiveness. Tracheae obtained from healthy non-treated guineapigs incubated in vitro with broncho-alveolar cells obtained from virus-infected animals, demonstrated an increased contraction in response to histamine and arecoline (Folkerts et al, 1992c).…”

Section: Histamine Nebulizationmentioning

confidence: 97%

Virus‐induced airway hyperresponsiveness in the guinea‐pig: possible involvement of histamine and inflammatory cells

Folkerts

Clerck

Reijnart

et al. 1993

British J Pharmacology

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1 Guinea-pig tracheal contractions by histamine and by the cholinoceptor agonist, arecoline, are significantly enhanced (30% and 20%, respectively), 96 h after intra-tracheal inoculation with Parainfluenza-3 (PI-3) virus. 2 The airway hyperresponsiveness in animals inoculated with virus coincides with a significant increase in the number of broncho-alveolar cells (82%), and in the albumin concentration (121%) in lung lavage fluid, relative to values obtained in guinea-pigs challenged with control solution. 3 The chemiluminescence production by isolated broncho-alveolar cells, obtained from virus-infected guinea-pigs 96 h after inoculation stimulated with PI-3 virus in vitro, is significantly reduced by 42% relative to broncho-alveolar cells obtained from animals inoculated with control solution. This diminution was not specific for stimulation by PI-3 virus since the chemiluminescence production was also significantly reduced by 30% in response to zymosan. 4 Pretreatment of the guinea-pigs with the anti-allergic drugs, oxatomide (2.5 mg kg-') or nedocromil (2.5 mg kg-'), or the specific HI-histamine receptor antagonist, levocabastine (0.25 mg kg-'), administered intra-peritoneally twice a day for five successive days, inhibits the virus-induced airway hyperresponsiveness, suppresses the influx of broncho-alveolar cells and increase in albumin content, and corrects the reduced chemiluminescence production by broncho-alveolar cells in response to zymosan. 5 In contrast, the cyclo-oxygenase inhibitor, suprofen (5.0 mg kg-1), the 5-HT2 receptor antagonist, ketanserin (0.63 mg kg-'), or the Ca2" overload blocker, flunarizine (2.5 mg kg-') do not modify the above mentioned processes. 6 The platelet-activating factor receptor antagonist, WEB 2170 (10 mg kg-'), reduces virus-induced airway hyperresponsiveness and influx of broncho-alveolar cells into the lungs but does not attenuate the increase of albumin in the bronchial lavage fluid. 7 Guinea-pigs nebulized with histamine, twice a day (30 min) during 4 successive days, do not demonstrate an increased airway responsiveness, but instead show tachyphylaxis in response to histamine in vitro. In addition, no influx of inflammatory cells is found in these animals. 8 These results suggest that histamine does not directly increase the responsiveness of the guinea-pig trachea; however, histamine may be involved in a cascade of events leading to airway hyperresponsiveness after a viral infection, a process that could be related to an influx and/or an activation of broncho-alveolar cells after PI-3 virus stimulation.

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Section: Histamine Nebulizationmentioning

confidence: 97%

Virus‐induced airway hyperresponsiveness in the guinea‐pig: possible involvement of histamine and inflammatory cells

Folkerts

Clerck

Reijnart

et al. 1993

British J Pharmacology

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“…Third, studies in rodents have demonstrated that morbidity of viral infections can be amplified by the passive transfer of certain T-cell subsets or clones. 66,[73][74][75] Although the immune responses to viruses are complex and involve multiple airway cells, cytokines, and mediators, there are a few cells and mediators that are likely to play key roles in this process. For example, the airway epithelial cell is the principal host cell for most respiratory viruses.…”

Section: Virus-induced Inflammationmentioning

confidence: 99%

The role of viral infections in the natural history of asthma

Gern

Busse

2000

Journal of Allergy and Clinical Immunology

110

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“…Third, there is evidence to support the role of the immune response to viruses in symptom pathogenesis in animal models of viral infection. For example, virus-induced airway hyperresponsiveness can be passively transferred in guinea pigs by passive infusion of bronchial alveolar lavage cells from infected animals (42), and morbidity and mortality of viral infections in mice is increased after passive transfer of certain virus-specific T cells (2,3,23).…”

Section: Effects Of Rhinovirus On Cellular Inflammationmentioning

confidence: 99%

Association of Rhinovirus Infections with Asthma

1999

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SUMMARY Rhinoviruses are the most common cause of the common cold, but they can cause more severe illnesses in people with underlying lung disorders such as asthma, chronic obstructive pulmonary disease, or cystic fibrosis. Epidemiologic studies with sensitive detection methods such as PCR have identified rhinovirus infection as a major source of asthma exacerbations in both children and adults, especially during the spring and fall. Since rhinoviruses cause little tissue destruction, it is presumed that the immune response to the infection may play an important role in the pathogenesis of rhinovirus-induced exacerbations of asthma. This review examines the epidemiologic association between rhinovirus infections and exacerbations of asthma and outlines current information on immune responses to rhinovirus infection and potential connections between antiviral responses and preexisting allergic inflammation. Finally, current and future strategies for treating rhinovirus infections and virus-induced exacerbations of asthma are discussed.

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Virus-induced airway hyperresponsiveness in the guinea pig can be transferred by bronchoalveolar cells

Cited by 19 publications

References 30 publications

Virus‐induced airway hyperresponsiveness in the guinea‐pig: possible involvement of histamine and inflammatory cells

Virus‐induced airway hyperresponsiveness in the guinea‐pig: possible involvement of histamine and inflammatory cells

The role of viral infections in the natural history of asthma

Association of Rhinovirus Infections with Asthma

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