Virus-induced cell surface antigens and cell-mediated immune responses

Shillitoe, Edward J.; Rapp, Fred

doi:10.1007/bf00198719

Cited by 11 publications

(4 citation statements)

References 140 publications

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“…Activated macrophages acquire the capability of discriminating between virus-infected and normal cells [25][26][27]. The mechanism by which macrophages select virus-infected from uninfected cells is unknown, although virus-induced changes in the macromolecular constitution of the host cell plasma membranes appear to play a major role [32]. In fact, recent studies with recombinant reoviruses have suggested that the recognition site on reovirus-infected target cells for mouse peritoneal cells is the virus hemagglutinin protein [33].…”

Section: Targeting Of Liposome-encapsulated Immunomodulators To Macromentioning

confidence: 99%

The potential use of liposome-mediated antiviral therapy

Koff

Fidler

1985

Antiviral Research

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The natural targeting of liposomes to cells of the reticuloendothelial system should be exploited to examine whether selective delivery of antiviral or immunomodulatory agents could be beneficial for the treatment of viral diseases. In this review we discuss the potential use of liposomes in the treatment of virus diseases, the targeting of liposome-encapsulated immunomodulators to macrophages in order to render these cells cytolytic for virus-infected cells, and the targeting of liposome-encapsulated antiviral drugs to macrophages to achieve direct suppression of virus replication within these cells.

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Section: Targeting Of Liposome-encapsulated Immunomodulators To Macromentioning

confidence: 99%

The potential use of liposome-mediated antiviral therapy

Koff

Fidler

1985

Antiviral Research

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“…In vitro assays of virus-specific cellular immunity generally involve the exposure of viable effector lymphocytes to virus antigens, followed by the measurement of some presumably relevant cellular response, such as proliferation, lymphokine release, or cytotoxicity (29,30). Because virus infection of the effector lymphocytes may alter these measured responses, the virus antigens used should be noninfectious (23)(24)(25).…”

mentioning

confidence: 99%

Psoralen inactivation of influenza and herpes simplex viruses and of virus-infected cells

Redfield¹,

Richman²,

Oxman³

et al. 1981

Infect Immun

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Psoralen compounds covalently bind to nucleic acids when irradiated with longwavelength ultraviolet light. This treatment can destroy the infectivity of deoxyribonucleic acid and ribonucleic acid viruses. Two psoralen compounds, 4'-hydroxymethyltrioxsalen and 4'-aminomethyltrioxsalen, were used with long-wavelength ultraviolet light to inactivate cell-free herpes simplex and influenza viruses and to render virus-infected cells noninfectious. This method of inactivation was compared with germicidal (short-wavelength) ultraviolet light irradiation. The antigenicity of the treated, virus-infected, antigen-bearing cells was examined by immunofluorescence and radioimmunoassay and by measuring the capacity of the herpes simplex virus-infected cells to stimulate virus-specific lymphocyte proliferation. The infectivity of the virus-infected cells could be totally eliminated without altering their viral antigenicity. The use of psoralen plus long-wavelength ultraviolet light is well suited to the preparation of noninfectious virus antigens and virus antigen-bearing cells for immunological assays. Cells. Rabbit kidney (RK13) cells were obtained from

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“…Viral antigen-induced lymphocyte transformation in humans has been reported for a wide variety of viruses, including CMV, EBV, HBV, HSV-1, HSV-2, influenza virus, measles virus, mumps virus, rabies virus, respiratory syncytial virus, retrovirus, rubella virus, vaccinia virus, varicella virus, and Venezuelan equine encephalitis (reviewed by Bellanti et ai., 1980). The lymphocyte transfor-mation response to HSV is maximal during acute primary infection, declines during convalescence, but remains at a detectable level thereafter (Shillitoe and Rapp, 1979). This response mayor may not exhibit a transient increase during a recurrent herpetic infection.…”

Section: Direct and Indirect T-lymphocyte-mediated Cytotoxicitymentioning

confidence: 99%

“…However, T-Iymphocyte-mediated effector responses such as LIF or MIF production are depressed in these individuals. A positive macrophage migrationinhibition response to HSV develops in individuals who recover from primary herpetic infection (Shillitoe and Rapp, 1979). Spleen cells from HSV-2-infected guinea pigs with a history of recurrent herpetic disease displayed significant impairment of both LIF and lymphocyte transformation responses when compared to seropositive controls (Donnenberg et al, 1980).…”

Section: Direct and Indirect T-lymphocyte-mediated Cytotoxicitymentioning

confidence: 99%

Immunopathology

1983

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Virus-induced cell surface antigens and cell-mediated immune responses

Cited by 11 publications

References 140 publications

The potential use of liposome-mediated antiviral therapy

The potential use of liposome-mediated antiviral therapy

Psoralen inactivation of influenza and herpes simplex viruses and of virus-infected cells

Immunopathology

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