Virus Infection and Systemic Inflammation: Lessons Learnt from COVID-19 and Beyond

Faist, Aileen; Janowski, Josua; Kumar, Sriram; Hinse, Saskia; Çalışkan, Duygu Merve; Lange, Julius; Ludwig, Stephan; Brunotte, Linda

doi:10.3390/cells11142198

Cited by 14 publications

(12 citation statements)

References 288 publications

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“…Despite the crucial roles of IFN and antiviral molecules in fighting virus infections, they often induce systemic inflammation that is highly possible to result in severe disease outcomes [ 40 ]. Plus, to date, several lines of evidence have linked the progression of severe forms of COVID-19 to CRS or cytokine storm syndrome (CSS) caused by the overproduction of proinflammatory cytokines and uncontrollable systemic inflammation [ 12 , 41 , 42 ].…”

Section: Inflammation In Sars-cov-2 Infectionmentioning

confidence: 99%

Prospective Roles of Tumor Necrosis Factor-Alpha (TNF-α) in COVID-19: Prognosis, Therapeutic and Management

Zawawi

Kalyanasundram

Zain

et al. 2023

IJMS

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The coronavirus disease 2019 (COVID-19) became a worldwide concern at the beginning of 2020 and has affected millions. Several previous studies revealed the impact of the imbalanced innate immune response on the progression of COVID-19 and its disease outcomes. High levels of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukins are produced readily by innate immune cells to fight Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infections. Nonetheless, cytokine-mediated inflammatory events are also linked to detrimental lung injury and respiratory failure, which can result in deaths among COVID-19 patients. TNF-α is amongst the early cytokines produced to mediate proinflammatory responses and enhance immune cell infiltration in response to SARS-CoV-2 infections. In COVID-19, TNF-α-mediated inflammation can cause detrimental tissue damage and gradually promotes lung fibrosis, which later results in pneumonia, pulmonary edema, and acute respiratory distress syndrome. This review, therefore, aims to deliberate the immunomodulatory roles of TNF-α in promoting inflammation and its relation with COVID-19 morbidity and mortality. In addition, this review also proposes the potential of TNF-α as a biomarker for the prognosis of severe COVID-19 and its related complications and as a molecular target for anti-TNF-α therapy.

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Section: Inflammation In Sars-cov-2 Infectionmentioning

confidence: 99%

Prospective Roles of Tumor Necrosis Factor-Alpha (TNF-α) in COVID-19: Prognosis, Therapeutic and Management

Zawawi

Kalyanasundram

Zain

et al. 2023

IJMS

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“…High oxidative stress has been associated with intense symptoms from Covid-19. 5 Inflammatory cytokines are present in patients with severe Covid-19 symptoms and can lead to increased morbidity from the disease. 6 Reducing oxidative stress and inflammation is a potential mechanism to mitigate the complications of Covid-19 infection.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In addition to antiviral effects, the antioxidant and anti-inflammatory properties of botanicals may be beneficial in reducing oxidative damage from the Covid-19 disease. High oxidative stress has been associated with intense symptoms from Covid-19 . Inflammatory cytokines are present in patients with severe Covid-19 symptoms and can lead to increased morbidity from the disease .…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Thyme (Thymus vulgaris) Extracts, Potential Inhibition of SARS-CoV-2 Spike Protein–ACE2 Binding and ACE2 Activity, and Radical Scavenging Capacity

Yao,

Whent,

et al. 2023

J. Agric. Food Chem.

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“…Inflammation is a prominent feature of many viral infections and contributes to disease severity and complications. [8,9] Chronic inflammation has also been linked to the development and progression of several diseases, including autoimmune disorders, cardiovascular diseases, neurodegenerative diseases, and cancer. [10][11][12] In the context of cancer, chronic inflammation can promote tumor initiation, progression, and metastasis through various mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…Inflammation is a prominent feature of many viral infections and contributes to disease severity and complications. [ 8,9 ]…”

Section: Introductionmentioning

confidence: 99%

Molecular insights into the anti‐inflammatory activity of fermented pineapple juice using multimodal computational studies

Tallei,

Fatimawali,

Adam

et al. 2023

Archiv der Pharmazie

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Pineapple has been recognized for its potential to enhance health and well‐being. This study aimed to gain molecular insights into the anti‐inflammatory properties of fermented pineapple juice using multimodal computational studies. In this study, pineapple juice was fermented using Lactobacillus paracasei, and the solution underwent liquid chromatography‐mass spectrometry analysis. Network pharmacology was applied to investigate compound interactions and targets. In silico methods assessed compound bioactivities. Protein–protein interactions, network topology, and enrichment analysis identified key compounds. Molecular docking explored compound–receptor interactions in inflammation regulation. Molecular dynamics simulations were conducted to confirm the stability of interactions between the identified crucial compounds and their respective receptors. The study revealed several compounds including short‐chain fatty acids, peptides, dihydroxyeicosatrienoic acids, and glycerides that exhibited promising anti‐inflammatory properties. Leucyl–leucyl–norleucine and Leu–Leu–Tyr exhibited robust and stable interactions with mitogen‐activated protein kinase 14 and IκB kinase β, respectively, indicating their potential as promising therapeutic agents for inflammation modulation. This proposition is grounded in the pivotal involvement of these two proteins in inflammatory signaling pathways. These findings provide valuable insights into the anti‐inflammatory potential of these compounds, serving as a foundation for further experimental validation and exploration. Future studies can build upon these results to advance the development of these compounds as effective anti‐inflammatory agents.

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Virus Infection and Systemic Inflammation: Lessons Learnt from COVID-19 and Beyond

Cited by 14 publications

References 288 publications

Prospective Roles of Tumor Necrosis Factor-Alpha (TNF-α) in COVID-19: Prognosis, Therapeutic and Management

Prospective Roles of Tumor Necrosis Factor-Alpha (TNF-α) in COVID-19: Prognosis, Therapeutic and Management

Chemical Composition of Thyme (Thymus vulgaris) Extracts, Potential Inhibition of SARS-CoV-2 Spike Protein–ACE2 Binding and ACE2 Activity, and Radical Scavenging Capacity

Molecular insights into the anti‐inflammatory activity of fermented pineapple juice using multimodal computational studies

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