Virus Infection in Patients With Histiocytic Necrotizing Lymphadenitis in Taiwan

Chiu, Chang-Fang; Chow, Kuan‐Chih; Lin, Tze–Yi; Tsai, Ming‐Hsui; Shih, Chi-Min; Chen, Li-Mien

doi:10.1309/1a6y-yckp-5avf-qtyr

Cited by 109 publications

(31 citation statements)

References 22 publications

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“…Arguably, the most commonly detected infectious agent in KFD is EBV. A study conducted by Chiu et al in Taiwan to detect viral DNA, RNA, and proteins in surgical lymph node specimens revealed EBV-encoded RNA by in situ hybridization in all 10 cases, EBV-DNA by PCR in nine cases, and EBVencoded protein by immunohistochemistry in only one case [16]. Neither human T cell leukemia virus-1 nor parvovirus B19 were detected.…”

Section: Discussionmentioning

confidence: 96%

“…The presence of fragmented nuclei suggests the involvement of apoptosis [20]. The Fas-Fas ligand system may play an important role in the occurrence of apoptosis in KFD, as evidenced by positive Fas reactivity in many lymph node cells in KFD [16,20]. The perforin pathway may also play a role in apoptosis in KFD [21].…”

Section: Discussionmentioning

confidence: 99%

“…Neither human T cell leukemia virus-1 nor parvovirus B19 were detected. The fact that many patients with KFD have elevated antibody titer to EBV argues for the involvement of EBV in the pathogenesis of KFD [16]. However, Hollingsworth et al [17] and Anagnostopoulos et al [18] argued against EBV as the causative agent because it is commonly detected in reactive lymphoid tissue.…”

Section: Discussionmentioning

confidence: 99%

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Kikuchi‐Fujimoto Disease: A Case Report

Lee

Cheng

2003

The Kaohsiung J of Med Scie

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We describe a rare but typical case of Kikuchi-Fujimoto disease (KFD). Two subcutaneous nodules appeared suddenly on the right of the neck of a 15-year-old girl. Microscopy of a surgical specimen of the larger nodule showed necrotizing lymphadenitis. Prompt treatment with mepirizole resulted in the disappearance of the smaller nodule. No recurrence was noted during 6 months of follow-up. KFD is a rare, self-limiting, necrotizing histiocytic lymphadenitis that needs to be differentiated from malignant lymphoma. Any nodal biopsy showing fragmented nuclei, necrosis, and karyorrhexis without prominent neutrophils should alert the physician to consideration of KFD, especially in a young woman presenting with cervical lymphadenopathy.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Kikuchi‐Fujimoto Disease: A Case Report

Lee

Cheng

2003

The Kaohsiung J of Med Scie

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“…The tubuloreticular inclusions were also noted in endothelial cells and lymphocytes in patients diagnosed with SLE 31. Due to the presence of reactive histiocytes and atypical lymphocytes, viral infections such as Epstein-Barr virus (EBV) and human T lymphocyte virus-1 (HTLV-1) were identified as possible causes of KFD 34. In situ hybridization, polymerase chain reaction (PCR), and immunohistochemistry revealed association between HTLV-1 infection and the development of KFD 34.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

Deaver

Naghashpour

Sokol

2013

Mediterr J Hematol Infect Dis

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Kikuchi-Fujimoto Disease (KFD), also known as histiocytic lymphadenitis, is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue. There is a higher incidence of KFD in women aged 20–35 years and in Asian populations. A PubMed search revealed 590 articles that described KFD. Of these, 22 cases have been fully described in the United States. Ten of the 22 (45%) patients were male and 12 (55%) were female, with 20% Caucasian, 20% Asian American, and the remaining 60% of other ethnic backgrounds. In this study, we describe an additional 3 cases of KFD and discuss the diagnosis, pathology, and management of KFD.

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“…In patient 1, the specificities of 809 bp amplified products of PVB19 were further investigated by DNA sequencing (ABI Prism, Perkin‐Elmer, Foster City, CA, USA). The primer sequences for CMV and EBV have been described previously (Chiu et al , 2000; Tsai et al , 2001).…”

Section: Signal Amplificationmentioning

confidence: 99%

Evidence of parvovirus B19 infection in patients of pre‐eclampsia and eclampsia with dyserythropoietic anaemia

Yeh¹,

Chiu²,

Lee³

et al. 2004

Br J Haematol

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Summary Parvovirus B19 (PVB19) infection can induce transient anaemia in patients with increased erythropoiesis. However, the dynamic change within the bone marrow after PVB19 infection is not well understood. Increased erythropoiesis is a physiological phenomenon in puerperital women. Nevertheless, anaemia as a result of PVB19 infection in puerperital women has never been reported. We report one patient with eclampsia and two patients with pre‐eclampsia who had transient, severe anaemia during the puerperital period because of PVB19 infection. Viral genomes were detected in the peripheral blood during the anaemic period by polymerase chain reaction and became undetectable after the anaemia was resolved. Viral genomes and protein could also be detected in bone marrow by in situ hybridization and immunohistochemical staining, respectively. Serial aspiration cytology of bone marrow showed severe dysplastic change involving erythroid precursors with a few apoptotic cells at the initial onset of anaemia, markedly increased apoptotic cells that was confirmed by the increased expression of activated caspase 3, around the nadir of anaemia, and a normal marrow picture without features of apoptosis after recovery from anaemia. Our data indicates that PVB19 infection can induce transient, severe dyserythropoietic anaemia in puerperital women with pre‐eclampsia/eclampsia and the pathogenetic mechanism may probably involve the induction of apoptosis following PVB19 infection.

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Virus Infection in Patients With Histiocytic Necrotizing Lymphadenitis in Taiwan

Cited by 109 publications

References 22 publications

Kikuchi‐Fujimoto Disease: A Case Report

Kikuchi‐Fujimoto Disease: A Case Report

Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

Evidence of parvovirus B19 infection in patients of pre‐eclampsia and eclampsia with dyserythropoietic anaemia

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