Virus Infection of The Human Papiloma And Its Association With Colorectal Cancer

Abstract

Colorectal cancer is the third most common cancer in men and women worldwide; its carcinogenesis is a complex multi-step process that involves environmental factors, lifestyle, genetic mutation and viral infections; Human papillomavirus (HPV) infection plays a crucial role in human carcinomas, mainly anogenital and oropharyngeal; HPV is a prognostic factor since it is associated with vascular invasion, ganglionic metastases and tumor size; HPV is reported to be present in 70% of colorectal cancers and HPV-16 E6 / E7 oncoproteins are involved in carcinogenesis, including colorectal cancer; prevention with HPV vaccines can prevent some cancers including colorectal cancer. The link between HPV and colorectal cancer became evident, without distinction between the sexes, with similar values ​​between HPV 16 and HPV 18. Studies are needed to investigate the relationship between HPV and colorectal cancer.