Virus infections and respiratory disease of childhood.

Gardner, P. S.

doi:10.1136/adc.43.232.629

Cited by 67 publications

(33 citation statements)

References 77 publications

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“…Thus, the adenoviruses and the parainfluenza viruses were particularly associated with tonsillitis and otitis media (Medical Research Council, 1965;Gardner, 1968;Clarke, 1973;Pereira, 1973). Diarrhoea was associated with rotavirus and with adenoviruses (Du Pont et at., 1977;Walker-Smith, 1978).…”

Section: Discussionmentioning

confidence: 99%

“…Rotavirus has always been associated with diarrhoea, but adenoviruses and enteroviruses could be responsible for either respiratory or gastrointestinal illness, depending on their site of maximal multiplication (Dalldorf and Melnick, 1965;Ginsberg and Dingle, 1965;Melnick, 1965;Pereira, 1973;Steinhoff, 1978). Of doubtful significance were bacterial Role of viruses in febrile convulsions 875 pathogens in throat swabs, which were isolated with similar frequency in gastroenteritis and febrile convulsions, and have been commonly found in the throats of healthy young children (Masters et al, 1958;Gardner, 1968). Although many children with febrile convulsions had clinical tonsillitis, a haemolytic streptococcus group A was isolated from only one throat.…”

Section: Discussionmentioning

confidence: 99%

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Role of viruses in febrile convulsions.

Lewis¹,

Parry²,

Parry³

et al. 1979

Archives of Disease in Childhood

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SUMMARY A disseminated viral illness was demonstrated by isolating a virus from the CSF, blood, or urine in 27% of 73 children who were admitted to hospital after a first febrile convulsion However, a viral aetiology could be implicated for 86% of the children after combining results of tissue culture, electron microscopy, mouse inoculation, complement fixation tests, and interferon assay. Parallel bacterial cultures showed a possible pathogen in 29 % of children, but in only 4 % was the pathogen isolated from the CSF, blood, or urine. No correlation was found between the nature of the pathogen (or evidence of its dissemination) and the severity of the convulsion, degree of fever, CSF protein, CSF white cells, or the WBC. The results suggest that a febrile convulsion could be a response to invasion of the blood stream or central nervous system by a micro-organism which is usually a virus. Invasion may be of such brief duration that successful isolation of the virus from the blood, CSF, or urine is not more commonly achieved.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Role of viruses in febrile convulsions.

Lewis¹,

Parry²,

Parry³

et al. 1979

Archives of Disease in Childhood

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“…Respiratory syncytial (RS) virus is a major cause of respiratory disease in infants under 1 year of age and remains an important pathogen up to the age of 2 (Gardner, 1968;Chanock & Parrott, 1965). Infection with this virus differs from other virus infections of childhood in that serious disease requiring hospitalization occurs primarily in the first 6 months of life when most infants are protected from the usual childhood viral infections by maternally derived antibody.…”

Section: Introductionmentioning

confidence: 99%

The Response of Infants with Bronchiolitis to the Proteins of Respiratory Syncytial Virus

Levine

Dajani²,

Klaiber-Franco³

1988

Journal of General Virology

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“…virus has been shown to be the chief viral pathogen in respiratory infections of infancy and the one most frequently associated with bronchiolitis (Chanock et al 1961;Gardner, 1968). Severe infection with this virus occurs predominantly in infants between 2 and 6 months of age.…”

Section: Introductionmentioning

confidence: 99%

The local antibody response to R.S. virus infection in the respiratory tract

Scott

Gardner

1974

J. Hyg.

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SUMMARYNasopharyngeal secretions were taken during the acute phase of illness from 66 infants and children admitted to hospital with lower respiratory tract infections. Second secretions were taken, after an interval of 7 days, from 33 of these patients. A significant increase in neutralizing activity to R.S. virus was demonstrated in the nasopharyngeal secretions of patients in response to severe R.S. virus infection.Seventeen out of 25 patients (68 %) with R.S. virus infections developed a rise in secretory neutralizing titre, compared with only 1 out of 8 patients (13 %) with respiratory infections not involving R.S. virus.A high titre of secretory neutralizing activity was found more often in the acute phase of illness in patients with R.S. virus infections, especially bronchiolitis, than in patients with respiratory infections not involving R.S. virus. A quantitative analysis of the immunoglobulins present in the secretions indicated that IgA was the only immunoglobulin consistently present at a detectable concentration. The geometric mean values of IgA, IgM and IgG in the secre tions examined were found to be 22-3 ,4 3 and 5-3 mg./100 ml. respectively.The neutralizing activity against R.S. virus, present in the secretions, was shown to be due to specific IgA antibody. This was accomplished by removing the neutralizing activity in two secretions by absorption with anti-IgA serum.

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Virus infections and respiratory disease of childhood.

Cited by 67 publications

References 77 publications

Role of viruses in febrile convulsions.

Role of viruses in febrile convulsions.

The Response of Infants with Bronchiolitis to the Proteins of Respiratory Syncytial Virus

The local antibody response to R.S. virus infection in the respiratory tract

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