Virus Infections of the Nervous System

Solomon, Tom; Ravi, Vasanthapuram

doi:10.1016/b978-0-7020-7959-7.00027-0

Cited by 2 publications

(1 citation statement)

References 208 publications

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“…[20] The relationship between viral infections and sensorineural hearing loss is well-established, with viruses such as mumps, measles, and rubella known to cause auditory dysfunction through mechanisms including direct viral invasion, immune-mediated damage, or vascular compromise. [21] The occurrence of hearing loss in COVID-19 patients has thus prompted investigations into the virus’s potential to similarly affect auditory function. [22] The auditory system, like its vestibular counterpart, is reliant on specialized structures for its function.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the impact of COVID-19 on vertigo and hearing impairment: A post-recovery analysis

Alshehri,

Alahmari

2024

Medicine

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The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has manifested with respiratory symptoms and a spectrum of extra-pulmonary complications. Emerging evidence suggests potential impacts on the auditory and vestibular systems, but the extent and nature of these effects in recovered individuals remain unclear. This study aimed to investigate the prevalence and severity of vertigo and hearing impairment in individuals who have recovered from COVID-19 and to identify potential risk factors associated with these sensory symptoms. A cohort of 250 recovered COVID-19 patients was assessed. Standardized questionnaires, including the Dizziness Handicap Inventory and the Vertigo Symptom Scale, were used to evaluate vertigo. Hearing assessment was conducted using pure-tone audiometry, speech audiometry, tympanometry, and oto-acoustic emissions testing. Logistic regression analysis was performed to assess the association between COVID-19 severity and the occurrence of sensory symptoms, controlling for confounding variables such as age and comorbidities. Of the participants, 10% reported vertigo, varying severity. Hearing assessments revealed that most participants had normal hearing, with an average speech discrimination score of 94.6. Logistic regression analysis indicated a significant association between severe COVID-19 and an increased likelihood of vertigo (OR 2.11, 95% CI 1.02–4.35, P = .043) and hearing impairment (OR 3.29, 95% CI 1.60–6.78, P = .002). This study suggests a significant association between COVID-19 severity and vertigo and hearing impairment prevalence. The findings underscore the importance of sensory symptom assessment in the post-recovery phase of COVID-19, highlighting the need for comprehensive healthcare approaches to manage long-term sequelae.

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Section: Introductionmentioning

confidence: 99%

Evaluating the impact of COVID-19 on vertigo and hearing impairment: A post-recovery analysis

Alshehri,

Alahmari

2024

Medicine

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Exploring the Role of IL-2 and IL-17 Levels in Patients infected with Varicella-Zoster Virus in Al-Najaf Al-Ashraf City

Naji Hamza,

Nima Mezher

2024

BIO Web Conf.

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About 60 samples were collected from patients with varicella zoster, including 24 males and 36 females, as well as from healthy people, which included 29 samples (15 males and 14 females), aged between 15 and 60 years. Data were collected between November 2022 and July 2023. VZV patients were selected from Sadr Medical City and private laboratories. The research used ELISA technology to measure the immune biomarkers IL2 and IL17 pg/ml in the serum of patients and healthy controls. The majority of patients fell within the age groups of 26–34 years and 36–45 years, constituting approximately 25%, with a mean and standard deviation of 37.17 ± 12.38. Conversely, the control group mostly belonged to the age group of 25 years and above, representing about 34.48%, with a mean and standard deviation of 26.86 ± 4.74. The results revealed a significant increase (p≤0.05) in IL2 and IL17 levels in the varicella zoster virus (VZV) patient group compared to the control group. Importantly, no significant differences were observed between male and female VZV patients. A strong positive correlation was found between IL-17 and IL-2 levels, with a correlation coefficient (R) of 0.768.

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Virus Infections of the Nervous System

Cited by 2 publications

References 208 publications

Evaluating the impact of COVID-19 on vertigo and hearing impairment: A post-recovery analysis

Evaluating the impact of COVID-19 on vertigo and hearing impairment: A post-recovery analysis

Exploring the Role of IL-2 and IL-17 Levels in Patients infected with Varicella-Zoster Virus in Al-Najaf Al-Ashraf City

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