Virus kinetics and biochemical derangements among children with Ebolavirus disease

Dysglycaemia in Ebola virus disease: a retrospective analysis from the 2018 to 2020 outbreak

“… 2 An episode of hyperglycaemia was defined as glucose >10.0 mmol/L. 2 , 11 For several analyses, patients were grouped based on longitudinal glucose measurements: The moderate hypoglycaemia group was defined as patients with one or more documented episodes of moderate hypoglycaemia, but no episodes of severe hypoglycaemia. The severe hypoglycaemia group was defined as patients with one or more episodes of severe hypoglycaemia.…”

“…The primary analysis examined the association between severe hypoglycaemia and mortality. Assuming a case fatality rate of 49% in the cohort, 14 and a 20% frequency of severe hypoglycaemia, 11 we would need 322 patients to detect a 20% difference in mortality between the groups, 15 with 80% power at the two-sided α = 0.05 level of significance.…”

“… 7 , 9 In children infected with EVD, hypoglycaemia (<4.0 mmol/L) was detected in 40% and 27% of patients in from Sierra Leone (2014–2015) 10 and DRC (2019), respectively. 11 World Health Organization guidelines for the optimised supportive care (oSoC) of EVD suggest that the glucose level should be checked at least three times a day and intravenous glucose be administered as needed. 12…”