Virus-like-inspired nanoparticles facilitate bacterial internalization for enhanced eradication of drug-resistant pathogens

Zhang, Yufei; Cheng, Yijie; Yu, Yunjian; Li, Jie; Hu, Yuqing; Gao, Yingchao; Huang, Siyuan; Wang, Wenbo; Zhang, Xinge

doi:10.1039/d2nj01868c

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…[30][31][32][33][34] Exhilaratingly, because of the rough surface which is consisted by spike proteins, biomimetic virus-based nanoparticles have been demonstrated to possess excellent cytomembrane evading ability. [35][36][37][38] Encouraged by the unprecedented invasion properties from morphology of virus, massive resent researches have been conducted to build the fascinating nanocarriers with the topological nanostructure of virus. Xie et al prepared nanospikes decorated TiO 2 nanoparticles, and investigated the effect of the virus-bionic surface to activate or attenuate the immune response both in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…As the most highly evolved organism with nanoparticulate morphology, viruses are intensively investigated as virus bionic nanovectors for drug delivery on account of their high infectivity [30–34] . Exhilaratingly, because of the rough surface which is consisted by spike proteins, biomimetic virus‐based nanoparticles have been demonstrated to possess excellent cytomembrane evading ability [35–38] . Encouraged by the unprecedented invasion properties from morphology of virus, massive resent researches have been conducted to build the fascinating nanocarriers with the topological nanostructure of virus.…”

Section: Introductionmentioning

confidence: 99%

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Virus‐Bionic Mesoporous Silica Nanoplatform for Malignant Tumor Inhibition via Effective Cellular Uptake and Precise Drug Delivery

Yang,

Xie,

Liao

et al. 2023

ChemMedChem

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Over the past few decades, sophisticated nanomaterials have been used as carries for the targeted delivery of therapeutics to solid tumors. However, the low efficiency of intracellular internalization of nanocarriers in current use restricts their biomedical application. In this work, we demonstrate that novel virus‐bionic mesoporous‐silica‐based nanocarriers can be successfully prepared for programmed precise drug delivery. These unique viral mimic nanovesicles not only present virus bionic counterparts and nanostructures, but also have infectious virus‐like properties toward tumor cells and tumor tissues. Encouragingly, their large surface area (322.1 m2/g) endows them with high loading capacity for therapeutic agents, especially, they have more effective gene transfection properties than the commercially available LipoGeneTM transfection reagent. Thanks to their virus‐inspired morphology, they exhibit outstanding cellular uptake efficiency with living tumor cells and the ability to invade cells in large quantities with incubation times as short as 5 min, which is much faster than traditional mesoporous silica nanoparticles (mSN) with smooth appearance. Importantly, after doxorubicin (DOX) loading and surface modification of tumor recognition motifs, RGD (Arg‐Gly‐Asp, vMN@DOX‐RGD), the bionic drug‐loaded viral mimics elicit potent tumor cell elimination both in vitro and in vivo, greatly exceeding the mSN‐based group. Our work paves the way toward virus bionic nanocarrier design for malignant tumor suppression in the clinic.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Virus‐Bionic Mesoporous Silica Nanoplatform for Malignant Tumor Inhibition via Effective Cellular Uptake and Precise Drug Delivery

Yang,

Xie,

Liao

et al. 2023

ChemMedChem

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Recent progress of intelligent antibacterial nanoplatforms for treating bacterial infection

Sun

You

et al. 2023

Chemical Engineering Journal

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High Cellular Internalization of Virus-Like Mesoporous Silica Nanoparticles Enhances Adaptive Antigen-Specific Immune Responses against Cancer

Phan,

Nguyen,

Choi

et al. 2024

ACS Appl. Mater. Interfaces

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Effective activation of an antigen-specific immune response hinges upon the intracellular delivery of cancer antigens to antigen-presenting cells (APCs), marking the initial stride in cancer vaccine development. Leveraging biomimetic topological morphology, we employed virus-like mesoporous silica nanoparticles (VMSNs) coloaded with antigens and toll-like receptor 9 (TLR9) agonists to craft a potent cancer vaccine. Our VMSNs could be efficiently internalized by APCs to a greater extent than their nonviral structured counterparts, thereby promoting the activation of APCs by upregulating the TLR9 pathway and crosspresenting ovalbumin (OVA) epitopes. In in vivo animal study, VMSN-based nanovaccines triggered substantial CD4 + and CD8 + lymphocyte populations in both lymph nodes and spleen while inducing the effector memory of adaptive T cells. Consequently, VMSN-based nanovaccines suppressed tumor progression and increased the survival rate of B16-OVA-bearing mice in both prophylactic and therapeutic studies. The combination of immune checkpoint blockade (ICB) with the VMSN-based nanovaccine has synergistic effects in significantly preventing tumor progression under therapeutic conditions. These findings highlight the potential of viral structure-mimicking mesoporous silica nanoparticles as promising candidates for antigen-delivering nanocarriers in vaccine development.

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Virus-like-inspired nanoparticles facilitate bacterial internalization for enhanced eradication of drug-resistant pathogens

Abstract: The emergence and rapid spread of bacterial resistance pose an extremely serious threat to treat infections. Inspired that the spiny surface structure of virus plays an important role in mediating...

Cited by 4 publications

References 45 publications

Virus‐Bionic Mesoporous Silica Nanoplatform for Malignant Tumor Inhibition via Effective Cellular Uptake and Precise Drug Delivery

Virus‐Bionic Mesoporous Silica Nanoplatform for Malignant Tumor Inhibition via Effective Cellular Uptake and Precise Drug Delivery

Recent progress of intelligent antibacterial nanoplatforms for treating bacterial infection

High Cellular Internalization of Virus-Like Mesoporous Silica Nanoparticles Enhances Adaptive Antigen-Specific Immune Responses against Cancer

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