Virus-mimicking nanosystems: from design to biomedical applications

Liu, Hao-Yang; Li, Xiao; Wang, Zhi-Gang; Liu, Shu-Lin

doi:10.1039/d3cs00138e

Chem. Soc. Rev.

2023

DOI: 10.1039/d3cs00138e

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Virus-mimicking nanosystems: from design to biomedical applications

Hao-Yang Liu,

Xiao Li,

Zhi-Gang Wang

et al.

Abstract: This review highlights the design principles and strategies of virus-mimicking nanosystems as well as their current status and challenges in biomedical applications.

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Cited by 6 publications

References 133 publications

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Regulation of Protein Conformation Enables Cell‐Selective Targeting of Virus‐Mimicking Nanoparticles for siRNA Therapy of Glioblastoma

Zhu,

Wang,

Wang

et al. 2024

Advanced Materials

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Orthotopic glioblastoma (GBM) has an aggressive growth pattern and complex pathogenesis, becoming one of the most common and deadly tumors of the central nervous system (CNS). The emergence of RNA therapies offers promise for the treatment of GBM. However, the efficient and precise delivery of RNA drugs to specific tumor cells in the brain with high cellular heterogeneity remains ongoing. Here, we propose a strategy to regulate protein conformation through lipid nano‐environments (RPCLN) to custom‐design virus‐mimicking nanoparticles (VMNs) with excellent selective cell targeting capabilities, leading to efficient and precise delivery of small interfering RNA (siRNA) for effective treatment of GBM. The optimized VMNs not only retain the ability to cross the blood‐brain barrier (BBB) and release the RNA by lysosomal escape like natural viruses but also ensure precise enrichment in the GBM area. This study lays the conceptual foundation for the custom design of VMNs with superior cell‐selective targeting capabilities and opens up the possibility of RNA therapies for the efficient treatment of GBM and CNS tumors.This article is protected by copyright. All rights reserved

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Regulation of Protein Conformation Enables Cell‐Selective Targeting of Virus‐Mimicking Nanoparticles for siRNA Therapy of Glioblastoma

Zhu,

Wang,

Wang

et al. 2024

Advanced Materials

Self Cite

View full text Add to dashboard Cite

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Bioinspired micro‐ and nanostructured systems for cancer therapy

Yang,

Zhang,

Fei

et al. 2024

MedComm

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Numerous organisms in nature have demonstrated enhanced biocompatibility, precise tumor targeting capabilities, and efficient tissue traversal within the human body. Drawing inspiration from these organisms, researchers have employed bioengineering, bioconjugation, and micro‐ or nanotechnology to fabricate bioinspired micro‐ and nanostructured systems. These systems play a crucial role in addressing the limitations of conventional anticancer drugs and nanomaterials concerning biocompatibility, effective penetration of physiological barriers, as well as selective tumor targeting, thereby leading to improved therapeutic efficacy while minimizing nonspecific adverse effects on healthy cells. Consequently, extensive exploration of these bioinspired micro‐ and nanostructured systems has been undertaken across various cancer treatment modalities with some progressing into preclinical or clinical stages. However, our understanding of this field remains limited which may impede research progress, clinical translation efforts, and practical applications. Therefore, this study presents a systematic classification of bioinspired micro‐ and nanostructured systems for cancer therapy that comprehensively elucidates their sources of inspiration and design principles. Furthermore, it extensively discusses the current status of clinical translation efforts while identifying prevailing challenges and exploring future prospects. This work will establish a robust theoretical framework and serve as a valuable reference to facilitate advancements in research and clinical application within this field.

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Biomimetic Materials for Antibacterial Applications

Zhang,

Dong,

Liu

et al. 2024

Small

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The rise of antibiotic resistance poses a critical threat to global health, necessitating the development of novel antibacterial strategies to mitigate this growing challenge. Biomimetic materials, inspired by natural biological systems, have emerged as a promising solution in this context. These materials, by mimicking biological entities such as plants, animals, cells, viruses, and enzymes, offer innovative approaches to combat bacterial infections effectively. This review delves into the integration of biomimicry with materials science to develop antibacterial agents that are not only effective but also biocompatible and less likely to induce resistance. The study explores the design and function of various biomimetic antibacterial materials, highlighting their therapeutic potential in anti‐infection applications. Further, the study provides a comprehensive summary of recent advancements in this field, illustrating how these materials have been engineered to enhance their efficacy and safety. The review also discusses the critical challenges facing the transition of these biomimetic strategies from the laboratory to clinical settings, such as scalability, cost‐effectiveness, and long‐term stability. Lastly, the study discusses the vast opportunities that biomimetic materials hold for the future of antibacterial therapy, suggesting that continued research and multidisciplinary collaboration will be essential to realize their full potential.

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Virus-mimicking nanosystems: from design to biomedical applications

Abstract: This review highlights the design principles and strategies of virus-mimicking nanosystems as well as their current status and challenges in biomedical applications.

Cited by 6 publications

References 133 publications

Regulation of Protein Conformation Enables Cell‐Selective Targeting of Virus‐Mimicking Nanoparticles for siRNA Therapy of Glioblastoma

Regulation of Protein Conformation Enables Cell‐Selective Targeting of Virus‐Mimicking Nanoparticles for siRNA Therapy of Glioblastoma

Bioinspired micro‐ and nanostructured systems for cancer therapy

Biomimetic Materials for Antibacterial Applications

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