Virus-Related Immunomodulation

Mims, Cedric

doi:10.1016/b978-0-12-095785-9.50035-4

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Also, all three viruses belong to families known to possess immunosuppressive abilities in other species of animals (Notkins et al 1970, Mims 1986, Kapil et al 1994. Therefore, these viruses may interfere with research.…”

Section: Discussionmentioning

confidence: 99%

Microbiological monitoring of laboratory pigs

Hansen

Farlov

Bollen³

1997

Lab Anim

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SummaryPurpose-bred minipigs, are often used as the non-rodent species in toxicology. Infections may interfere with animal experiments, and there are no scientific reasons why the non-rodent species should be of a lower microbiological quality than the rodent species. Therefore, a system for health monitoring of pigs was developed in order to raise the quality of laboratory pigs to the level of laboratory rodents. This system, which includes screening for several viruses, bacteria and ecto-and endoparasites, was used for monitoring mini pigs from a barrier unit with the same standards applied to rodents units. In these pigs only rotaviruses are found, which was shown by both serological antibody detection and by detection of rotaviral antigen in faeces. In minipigs from another unit with far less hygienic protection rotaviruses were also found along with certain influenza-and coronaviruses, as well as Pasteurella spp. It is concluded, that it is possible to raise pigs of a microbiological quality comparable to the quality of rats and mice, and that advanced microbiological monitoring in pigs will reveal useful information.

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Section: Discussionmentioning

confidence: 99%

Microbiological monitoring of laboratory pigs

Hansen

Farlov

Bollen³

1997

Lab Anim

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Animal welfare and colony management in cancer research

Schiffer

1997

Breast Cancer Res Treat

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The use of animals in cancer research continues to be important for the study of tumor biology, the development and testing of new therapies, and risk assessment. The new knowledge generated from this research contributes to the health and welfare not only of human beings, but also of animals which develop cancer. However, the use of animals for cancer research is a privilege which carries with it scientific, professional, and moral obligations. The three tenets of a sound animal research program include good science, humane care, and regulatory compliance. Recognizing the complex interactions in the tumor-animal model, the investigator needs to address a wide range of issues during experimental design and implementation including animal welfare concerns, complicating factors in colony management, and compliance with laws, regulations, and policies. Therefore, both practical and philosophical considerations enjoin researchers to maintain the highest standards of animal care.

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Virus-Related Immunomodulation

Cited by 2 publications

References 67 publications

Microbiological monitoring of laboratory pigs

Microbiological monitoring of laboratory pigs

Animal welfare and colony management in cancer research

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