Viruses and cancer of the lower genital tract

Josey, William E.; Nahmias, André J.; Naib, Zuher M.

doi:10.1002/1097-0142(197607)38:1<526::aid-cncr2820380176>3.0.co;2-e

Cited by 43 publications

(4 citation statements)

References 40 publications

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“…There seems to be a connection between infections with herpes simplex virus type 2 and dysplasia and cancer of the cervix (1 8-2 1). The herpes infection may be of etiologic significance, possibly acting as a cofactor or promoting agent (18)(19)(20)(21). This may be relevant to the present study, since immunosuppressed patients, including those on azathioprine, are prone to develop infections with the herpes group viruses, including herpes simplex, possibly through reactivation of latent infections (22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 94%

Increased incidence of cervical atypia in women with systemic lupus erythematosus treated with chemotherapy

Nyberg

Eriksson

Westberg

1981

Arthritis & Rheumatism

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In a retrospective study we found that 19 of 80 women with systemic lupus erythematosus had atypical cervical smears as compared to only 9 of 80 agematched women without the disease. This increased incidence occurred mainly among women receiving cytotoxic drugs. Cervical atypia in women with lupus was not morphologically different from cervical atypia in general. Possible mechanisms responsible for the increased incidence are discussed. It is concluded that women with lupus who receive chemotherapy should have cervical smears taken regularly.Malignant disease has been reported to be more common in persons with systemic lupus erythematosus (SLE) (1,2). Malignant lymphoma is the malignancy most commonly discussed in relation to SLE. It has been debated whether the lymphomas are related to the immune disorder itself or to the immunosuppressive therapy (3-8). Cancer of the cervix is included among the neoplasms found (1,2), but so far no study has shown a statistically significant increase. The purpose of the present investigation was to reveal any increased incidence of cervical atypia in women suffering from lupus and to evaluate the relationship to chemotherapy. PATIENTS AND METHODSOne hundred and twenty women with strongly suspected or established diagnoses of systemic lupus erythema- Submitted for publication October 29, 1980; accepted in revised form November 19, 1980. tosus were included in the study. They had been seen at the Departments of Medicine, Dermatology, Rheumatology, or Neurology at Sahlgrenska Hospital, Goteborg, or at the Medical Department at the County Hospital in Molndal. No selection was made with regard to the age of the patients (median 42 years; range 20-80), organs affected, degree of activity, or therapy given. Thus, the women included cover a wide spectrum of this disease. Their records were studied, and time of onset of symptoms, year of diagnosis, and duration of any chemotherapy were noted. Most patients were presently or had previously received treatment. No attempt was made to evaluate the extent of this therapy.At the Laboratory of Clinical Cytology at Sahlgrenska Hospital, records of patients are filed in a computer registry according to their birthdate. These records include the results of any previous cytologic and relevant histologic examinations. The registry now contains data from more than 300,000 women.Of the 120 women with SLE, 80 were found to have previous cytologic records.* We used the computer files to choose 80 controls. For each of these 80 SLE patients, the control subject was the woman whose file immediately preceded the file of the SLE patient. In 74 cases, the control was born on the same day as the patient, and, in the remaining 6 cases, the control was one day older.Women with repeated cytologic or histologic examinations were recorded according to their "most malignant" report. In this context, cervical atypia was defined as any epithelial abnormality within the range of slight dysplasia to invasive carcinoma, corresponding to Papanicolaou classes 11-V. T...

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Section: Discussionmentioning

confidence: 94%

Increased incidence of cervical atypia in women with systemic lupus erythematosus treated with chemotherapy

Nyberg

Eriksson

Westberg

1981

Arthritis & Rheumatism

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“…Only one of our patients received irradiation but she did develop an extensive area of vulval carcinoma. Viral carcinogens have been suggested; herpes simplex virus I1 (Franklin & Rutledge 1972;Josey et al 1976) and human papilloma virus Meisels & Morin 1981). There is a significant association of sexually transmitted diseases, especially condyloma accuminatum, in patients with vulval intraepithelial neoplasia (Morrow & Townsend 1981).…”

Section: Discussionmentioning

confidence: 99%

Multicentric carcinoma of the female lower genital tract

Hammond

Monaghan

1983

BJOG

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“…venereally transmitted disease (22,23,27,31). There are numerous recent reports suggesting that the human cervical carcinoma, too, is primarily transmitted by sexual contact (13,16,25,33,35). Thus, the possibility that there exists a causal relationship between the genital wart virus and uterine cervical carcinoma has been explored by numerous authors (19,22,23,25,31,40).…”

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confidence: 99%

Condylomatous Epithelial Changes in the Uterine Cervix and Their Relationship to Cervical Carcinogenesis

Syrjänen¹

1980

Obstetrical & Gynecological Survey

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Syrjànen KJ (Dept of Pathology, Pdijat-Hame Central Hospital, Lahti, Finland). Condylomatous epithelial changes in the uterine cervix and their relationship to cervical carcinogenesis. Int J Gynaecol Obstet 17: 415-420, 1980 Two hundred twenty-six (226) women with histologically verified dysplastic or neoplastic epithelial lesions in the uterine cervix were assessed for the presence (CO-series) or absence (N-CO-series) of the three newly established types of condylomatous lesions. Both the CO-series and the N-COseries comprised 113 patients. Histologic changes fulfilling the previously outlined criteria of the (a) fiat, (b) inverted and (c) papillomatous condylomas were found in association with all degrees of epithelial atypia, from mild dysplasia to frankly invasive carcinoma. The flat type was most common, comprising 69% of all condylomas. The inverted and papillomatous types were relatively rare, with frequencies of 18.6% and 12.4%, respectively. The mean age of the patients in the CO-series was 30.9 years, that of the N-CO-series patients was 39.3 years (p < 0.0001). The causal relationship between the cervical condylomas and cervical carcinoma is discussed. The conclusion is drawn that this possibility needs to be seriously considered when searching for a venereally transmitted agent as an etiologic factor of cervical carcinoma. Int J Gynaecol Obstet 17

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Viruses and cancer of the lower genital tract

Cited by 43 publications

References 40 publications

Increased incidence of cervical atypia in women with systemic lupus erythematosus treated with chemotherapy

Increased incidence of cervical atypia in women with systemic lupus erythematosus treated with chemotherapy

Multicentric carcinoma of the female lower genital tract

Condylomatous Epithelial Changes in the Uterine Cervix and Their Relationship to Cervical Carcinogenesis

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