In this article, I argue for a realist anthropology based on the recognition of mind-independent reality; pitching this premise against concerted anti-dualist tendencies in contemporary anthropological thinking. I spell out core analytical entailments of these, in my view, profoundly conflicting premises. In particular, I focus on perspectival multi-naturalism, arguing that despite adherents’ claims to reinvigorate studies of ‘ontology’, this approach instead exaggerates epistemological dimensions. When assessed from a realist stance, its ground position engenders a series of epistemic fallacies by which the ontological is, effectively, subordinated under epistemology. Advocates’ reluctance to appreciate a distinction between mind and mind-independent reality entails a profound contraction of perspective in terms of empirical and methodological scope, and, analytically, a disregard for ontological complexity and depth, thus curtailing the importance of anthropology in wider academic discourse.