Viruses in Lymph Nodes of Children with Mesenteric Adenitis and Intussusception

Bell, Thomas M.; Steyn, J. H.

doi:10.1136/bmj.2.5306.700

Cited by 62 publications

(20 citation statements)

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“…The greater disproportion between the size of ileum and the ICV in infants compared with that in older children has been suggested as a contributing factor for intussusception [9]. The popular theory at present suggests that there is a primary lymphoid hyperplasia in the distal small intestine secondary to infective agents and that some of these enlarged lymphoid aggregates or hypertrophied Peyer patches become entrapped in the intestine, serving as lead points for the intussusception [10]. However, in the LPS-induced animal model of intussusception, none of the animals showed prominent mucosal lymphoid follicles, hypertrophied Peyer patches, or other pathologic process at the apex of the intussusception [6].…”

Section: Discussionmentioning

confidence: 99%

New hypothesis on the pathogenesis of ileocecal intussusception

Cserni

Paran

Puri

2007

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 99%

New hypothesis on the pathogenesis of ileocecal intussusception

Cserni

Paran

Puri

2007

Journal of Pediatric Surgery

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“…However, US did not depict any PLP in our series even if in two of our patients a PLP was certainly identified at surgical intervention (one case a Merckel Diverticulum and one case a tenual polyp). However, in five patients we found enlarged nodes near the mass suspected to be an intussusception according to the popular theory that suggests that there is a primary lymphoid hyperplasia in the distal small intestine secondary to infective agents, especially viruses, and that some of these enlarged lymph nodes aggregates or hypertrophied Peyer patches become entrapped in the intestine, serving as lead points for the intussusception [6,7]. A correct execution of US examination also requires a careful search for abdominal fluid, as free peritoneal fluid or localized near interested bowels, also known as the ''trapped-fluid sign'', caused by trapped fluid between the serosal surfaces of intussuscepted loops [17].…”

Section: Discussionmentioning

confidence: 99%

“…1) [1][2][3]. The pathogenesis of intussusception is in approximately 90 % of cases idiopathic and is assumed to be secondary to uncoordinated peristalsis of the gut or to lymphoid hyperplasia, which may be due to a recent GI infection [4][5][6][7][8][9]. Approximately 5-6 % of intussusceptions in children have pathologic lead points (PLP) which are due to either focal masses or diffuse bowel wall abnormality.…”

Section: Introductionmentioning

confidence: 99%

Intussusception in childhood: role of sonography on diagnosis and treatment

Bartocci¹,

Fabrizi²,

Valente³

et al. 2014

J Ultrasound

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Objective The aim of this study was to determine the role of ultrasound in the diagnosis and treatment of pediatric patients with acute abdominal pain caused by intussusceptions. Materials and methods We performed a retrospective study of all pediatric patients with acute abdominal pain caused by intussusceptions and that underwent ultrasound examination at the emergency service of the Radiology Department between November 2007 and June 2013. The role of ultrasonography in the diagnosis of intussusceptions has been assessed by comparing the echographic presumptive diagnosis with the final diagnosis of discharge. Its importance in the treatment has been assessed by determining the value of ultrasound findings in the choice of the best treatment. Results The ultrasound examination was positive in 16/18 patients with a final diagnosis of intussusception. Some sonographic findings seemed to be able to predict the opportunity to resort to non-surgical therapeutic options like hydrostatic or pneumatic reduction of the intestinal segments invaginated. In our casuistry, five children presented characteristics typical of this subgroup and underwent barium enema which provided the reduction of the intestinal segments involved. The future challenge will be to perform non-surgical ultrasound-guided reductions to avoid the exposure of the infants to ionizing radiations. Conclusions Ultrasonography is essential not only in the diagnosis, but also it adds important elements in the therapeutic choice and could play in the future an important role in non-surgical reduction of intestinal intussusceptions in pediatric patients.Keywords Intussusception Á Childhood Á Sonography Riassunto Obiettivo Accertare il ruolo dell'ecografia nella diagnosi e trattamento dei pazienti pediatrici con dolore addominale acuto causato da invaginazione intestinale. Materiali e metodi Abbiamo eseguito uno studio retrospettivo su tutti i pazienti pediatrici con dolore addominale acuto causato da intussuscezione e sottoposti ad esame ecografico presso il servizio di emergenza del Dipartimento di Radiologia tra il Novembre 2007 ed il Giugno 2013. Il ruolo dell'ecografia nella diagnosi di intussuscezione è stato valutato comparando la diagnosi presuntiva ecografica con la diagnosi finale di dimissione; per ciò che concerne la sua importanza nel trattamento, ci si è basati sull'influenza dei reperti ecografici sul percorso terapeutico. Risultati Su 18 pazienti con diagnosi finale di intussuscezione l'esame ecografico è risultato positivo in 16 casi; inoltre è stato possibile osservare che alcuni reperti ecografici sembrano essere in grado di predire l'opportunità di ricorrere ad opzioni terapeutiche non chirurgiche, vale a dire riduzione idrostatica o pneumatica del segmento intestinale invaginato. Nella nostra casistica, 5 bambini hanno presentato caratteristiche tali da rientrare in questo sottogruppo, e pertanto sono stati sottoposti a clisma opaco, 123J Ultrasound (2015( ) 18:205-211 DOI 10.1007 tramite cui in 3 casi si è ottenuto lo svaginam...

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“…Once attention was directed to the association between intussusception and adenovirus, several studies followed where it was demonstrated that a significantly larger number of patients with intussusception (26.3-90.1%) shed adenovirus than patients with other diseases (2.6-6.2%) or healthy controls (0-8.0%) (1,10,18,19,48,51,52,56). To take an example from Gardner et al's study (19), the odds ratio for having intussusception in the adenovirus-positive group over the adenovirus-negative group is calculated to be 25.7 (95%CI= 8.57-77.1), lending strong support for the role of adenovirus infection in the etiology of intussusception.…”

Section: Adenovirus: the Paradigm For Viral Infection And Intussuscepmentioning

confidence: 99%

Rotavirus Infection and Intussusception: A View from Retrospect

Nakagomi

2000

Microbiology and Immunology

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A live orally-administrable rhesus rotavirus (RRV) tetravalent (TV) vaccine, licensed in the U.S.A. and the European Union, was recalled from the market because it was suspected to increase the risk of intussusception during the week following immunization. In contrast, natural rotavirus infection is generally believed not to cause intussusception. Because my experience contributed to the first paper that linked intussusception with rotavirus infection, I have re-examined our own data published 22 years ago and other studies on this issue. I also made a case study of adenovirus and intussusception as a paradigm to establish an etiological association of viral infection and intussusception. My hypothesis postulated in this review is that natural infection of susceptible (or predisposed) infants with some rotavirus strains, probably serotype G3 rotaviruses, will result in an appreciable fraction of idiopathic intussusception. Thus, the number of rotavirus-induced intussusception cases may change reflecting the relative frequency of G3 strains, which I believe was much higher in the 70s than during the last two decades. The epidemiological data indicate that the RRV-TV vaccine triggers intussusception at a rate significantly higher than the background incidence rate following the week of vaccination, particularly after the first dose. In contrast, the data do not suggest that the cumulative incidence among the vaccine recipients increases accordingly, implicating that the risk of intussusception attributable to the RRV-TV vaccine may be minimal.

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Viruses in Lymph Nodes of Children with Mesenteric Adenitis and Intussusception

Cited by 62 publications

References 10 publications

New hypothesis on the pathogenesis of ileocecal intussusception

New hypothesis on the pathogenesis of ileocecal intussusception

Intussusception in childhood: role of sonography on diagnosis and treatment

Rotavirus Infection and Intussusception: A View from Retrospect

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