Viruses Transmissible from Laboratory Animals to Man

Tobin, J. O'h.

doi:10.1258/002367768781035458

Cited by 11 publications

(6 citation statements)

References 36 publications

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“…There is no possibility of eradicating the tolerant form of the infection from uncontrollable wild mouse populations but there is a strong case for the monitoring of all laboratory-bred and fancy-bred mice and for their isolation from contact with wild house mice or unmonitored strains of mice. It is to be hoped that all who see the potential danger will exert their influence to this end and will take action on the general safety principles expounded by Darlow (1967) and Tobin (1968).…”

Section: Discussionmentioning

confidence: 99%

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Monitoring mouse stocks for lymphocytic choriomeningitis virus-a human pathogen

Skinner

Knight

1971

Lab Anim

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Wild house mice (Mus musculus) persistently infected with high titres of lymphocytic choriomeningitis virus (tolerant infection) are the source of human inapparent and overt infections, the latter sometimes being of a serious nature. Infections have also occurred in laboratory staff studying the virus and in others handling biological materials contaminated with it. The literature is reviewed.Great Britain is one of the countries in which pockets of infected wild house mice exist, and these can be a source of infection for laboratory mouse colonies within which congenital transmission through tolerantly infected females would be the main method of spread. Overt signs of the infection may not be detected in mice, and absence of the infection would be certain only if 100% of the litters from which future breeding stock are to be selected were monitored for infectivity and maintained in isolation from unmonitored mice. A suitable monitoring technique is described.It must be the aim of all breeders of mice to eliminate the possibility of their colonies being a potential hazard to human health. The life-long high infectivity of tolerantly infected mice provides a long-term source of infection for those who handle them and for other biological materials in which the virus can persist without recognition. PRUFUNG VON MAUSESTAMMEN AUF DAS VORHANDENSEIN VON LYMPHOZYTAREM CHORIOMENINGITIS VIRUS -EIN PATHOGEN FUR DEN MENSCH EN Wilde Hausmause (Mus musculus), die standig mit hohen Titern von lymphozytarem Choriomeningitis Virus infiziert sind (tolerierte Infektion), sind eine QueUe fUr menschliche unsichtbare und offene Infektionen, deren Letztere haufig sehr ernster Natur sein kannen. Infektionen sind auch in Laborangestellten vorgekommen, die den Virus studierten, und in anderen vom Personal, wenn sie biologisches Material handhabten, das dam it infiziert war. Es wird eine Ubersicht tiber die Literatur gegeben. Grossbritannien ist eines der Lander, in denen man Gegenden mit infizierten wilden Hausmausen findet, und diese konnen eine Infektions-73 74 H. H. SKINNER AND E. H. KNIGHT quelle ftir Labormausekolonien werden, in denen congenitale Ubertragung durch toleriert infizierte Weibchen die Hauptart der Weiterverbreitung darstellt. Offene Zeichen der Jnfektion werden nicht immer an den Mausen bemerkt, und man ware der Abwesenheit dieser Infektion nur dann sicher, wenn 100 % von den Wilrfen, aus denen zukUnftige Bruttiere ausgewahlt werden, auf Infektion untersucht wiirden, und sie in volliger Isolierung von ungepriiften Mausen gehalten werden. Eine geeignete PrUfungsmethode wird beschrieben. Es muss das Ziel aller Mauseziichter sein, die Moglichkeit, dass ihre Kolonien eine potentielle Gefahr fUr die menschliche Gesundheit waren, v611ig auszuschliessen. Die lebenslanglich hohe Infektivitat toleriert infizierter Mause bedeutet eine langfristige Infektionsquelle fUr aile, die mit ihnen umgehen, und auch fUr anderes biologisches Material, in dem der Virus fortleben kann, ohne erkannt zu werden. VERIFICATION DES COLONIES DE SO...

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Section: Discussionmentioning

confidence: 99%

“…About 14 infections, mostly clinical, have been recorded in workers studying the virus (Farmer & Janeway, 1942;Milzer & Levinson, 1942;Duncan, Thomas & Tobin, 1951;Scheid, Jochheim & Mohr, 1956;Cohen et at., 1966;Tobin, 1968). Cohen et at.…”

Section: Murine Lymphocytic Choriomeningitis As a Source Of Human Infmentioning

confidence: 99%

Monitoring mouse stocks for lymphocytic choriomeningitis virus-a human pathogen

Skinner

Knight

1971

Lab Anim

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“…Several authors have emphasized the association between the actual handling of infected mice and the contraction of the disease by humans (Dykewicz et al 1992;Havens 1948;Smithard and Macrae 1951). Several cases of human infection have suggested the possibility that infected rodent tissues can serve as a source of infection for laboratory personnel (Baum et al 1966;Dykewicz et al 1992;Tobin 1968). Humans may be infected by inhalation or by the contamination of mucous membranes or broken skin with infectious tissues or fluids from infected animals.…”

Section: Mode Of Transmissionmentioning

confidence: 99%

Zoonoses and Other Human Health Hazards

Newcomer¹,

Fox²

2007

The Mouse in Biomedical Research

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“…Virtually all cells can be infected with the virus. Most human laboratory infections have been associated with improper han dling of infected murine tissues (Baum et aL, 1966;Tobin, 1968). Before manipulative procedures begin, all murine tumor lines should be screened for this virus.…”

Section: Mode Of Transmissionmentioning

confidence: 99%