Visceral Adiposity index and atherogenic index of plasma as reliable indices to prediction of cardiovascular diseases in adults: A Cross-Sectional analysis from the Iranian RaNCD Cohort Data

Abstract

Background: Visceral Adiposity index (VAI) and atherogenic index of plasma (AIP) are relatively new indicators for predicting Non-Communicable disease (NCDs). The aim of this study was to assess the association AIP and VAI with risk of developing cardiovascular diseases (CVDs) in adults.Materials: This was a cross-sectional analysis conducted on 7362 individuals aged 35 to65 years participated in Ravansar Non-Communicable Diseases (RaNCD) cohort study. AIP was calculated based on the value of TG and HDL-C. VAI was calculated using BMI (Body mass index), waist circumference (WC), serum triglyceride, and High density lipoprotein cholesterol (HDL-C).All participants were stratified into three groups based on AIP and VAI tertiles. Simple and multiple logistic regression models were applied to assess the effect of these indices on CVDs.Results: The mean of AIP and VAI was significantly higher in CVDs patients than in non-CVDs (P < 0.001). After adjusting for age, sex hypertension, hyperlipidemia and smoking the risk of CVDs in the second and third tertile of AIP were 1.27 (95% CI: 1.06, 1.52) and 1.63 (95% CI: 1.31, 2.03) times higher comparing to the first tertile, respectively. Risk of CVDs in the second and third tertile of VAI were1.41 (95% CI: 1.18, 1.70) and 1.98 (95% CI: 1.60, 2.46) times higher than the first tertile, respectively; while adjusting for age, sex, hypertension and dyslipidemia.Conclusion: According to the findings, AIP and VAI were positively associated with CVDs in adults. Therefore, AIP and VAI can be useful in identifying high-risk subgroups of CVDs in general population.