Visceral adiposity index and triglyceride/high-density lipoprotein cholesterol ratio in hypogonadism

Abstract

Background: Cardiometabolic risk is high in patients with hypogonadism. Visceral adiposity index (VAI) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio are the practical markers of atherosclerosis and insulin resistance and independent predictors of cardiaovascular risk. To date, no study has evaluated VAI levels and TG/HDL-C ratio in hypogonadism. Subjects and methods: A total of 112 patients with congenital hypogonadotrophic hypogonadism (CHH) (mean age, 21.7 ± 2.06 years) and 124 healthy subjects (mean age, 21.5 ± 1.27 years) were enrolled. The demographic parameters, VAI, TG/HDL-C ratio, asymmetric dimethylarginine (ADMA), high-sensitivity C-reactive protein (hs-CRP), and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured for all participants. Results: The patients had higher total cholesterol (p = 0.04), waist circumference, triglycerides, insulin, and HOMA-IR levels (p = 0.001 for all) than the healthy subjects. VAI and ADMA and TG/HDL-C levels were also higher in patients than in healthy subjects (p < 0.001 for all). VAI was weakly correlated with ADMA (r = 0.27, p = 0.015), HOMA-IR (r = 0.22, p = 0.006), hs-CRP (r = 0.19, p = 0.04), and total testosterone (r = −0.21, p = 0.009) levels, whereas TG/HDL-C ratio was weakly correlated weakly with ADMA (r = 0.30, p = 0.003), HOMA-IR (r = 0.22, p = 0.006), and total testosterone (r = −0.16, p = 0.03) levels. Neither VAI nor TG/HDL-C ratio determined ADMA, HOMA-IR, and hs-CRP levels. Conclusions: The results of this study demonstrate that patients with hypogonadism have elevated VAI and TG/HDL-C ratio. These values are significantly correlated with the surrogate markers of endothelial dysfunction, inflammation, and insulin resistance. However, the predictive roles of VAI and TG/HDL-C ratio are not significant. Prospective follow-up studies are warranted to clarify the role of VAI and TG/HDL-C ratio in predicting cardiometabolic risk in patients with hypogonadism. Arch Endocrinol Metab. 2017;61(3):282-7.

Male Obesity-related Secondary Hypogonadism – Pathophysiology, Clinical Implications and Management

“…12–14 Testosterone deficiency is associated with visceral fat dysfunction, subsequent chronic inflammation, insulin resistance and low sex hormone binding globulin (SHBG) levels. 15,16 Weight loss achieved pharmacologically with liraglutide 17 or with bariatric surgery improved testosterone and gonadotrophin levels, and were able to reverse the hypogonadotrophic hypogonadism caused by obesity. 18–20…”

A Razão TGL/HDL É Capaz De Predizer Um Pior Prognóstico Na Deficiência De Testosterona?

“…Essa medida está associada ao aumento do risco de DCV e consequente mortalidade. (BORRAYO et al, 2018;HAJIAN-TILAKI;HEIDARI;BAKHTIARI, 2020;HAYMANA et al, 2017) A relação TG / HDL tem forte associação positiva com HOMA-IR na população. Portanto, consiste em um método fácil e parâmetro econômico em contextos clínicos, atuando como um marcador substituto para RI, disfunção endotelial e inflamação.…”

“…Portanto, consiste em um método fácil e parâmetro econômico em contextos clínicos, atuando como um marcador substituto para RI, disfunção endotelial e inflamação. (CHUNG;KWON;LEE, 2020;DI BONITO et al, 2012;HAYMANA et al, 2017) A DT sérica tem sido associada à obesidade, DM2, SM e aterosclerose, além do aumento da mortalidade por todas as causas em homens. Indivíduos com essas comorbidades têm maior risco de morte prematura e outros efeitos adversos à saúde.…”

Prevalence and clinical associations with primary hypogonadism in male systemic sclerosis

“…Hypertriglyceridemia was another factor significantly associated with primary hypogonadism in male SSc patients. Hypertriglyceridemia has been reported to be related to hypogonadism 35,36 and increased TG levels with low levels of high-density lipoprotein (HDL), which are features of males with hypogonadism. 36 Haymana et al 36 also reported that a high TG/HDL ratio was correlated with endothelial dysfunction and inflammation.…”