Visceral adiposity index is associated with lung function impairment: a population-based study

Abstract

Background The effects of visceral adiposity on decreased lung function have drawn much attention. Recently, the visceral adiposity index (VAI) has been proposed as a visceral fat distribution and dysfunction marker. However, the relationship between the VAI and lung function has not been investigated. The objective of the study was to analyze the association between the VAI and lung function and evaluate the potential of VAI as a predictor of lung function. Methods We collected data from a population-based study of 1786 subjects aged 40 years or older. All subjects completed a questionnaire and underwent anthropometric measurements and laboratory tests. Linear and logistic regression models were developed to assess the association between the VAI and lung function. Results The VAI was inversely related to FVC%predicted in men and negatively associated with both FVC%predicted and FEV1%predicted in women. In the linear regression analysis, the decrease in FVC%predicted associated with each 10% increase in the VAI was 1.127% in men and 1.943% in women; the decrease in FEV1%predicted associated with each 10%increase in the VAI was 0.663% in men and 1.738% in women. Further regression analysis revealed that the VAI was positively correlated with FVC and FEV1 impairment in women. Conclusions We were the first to show a clear correlation between the VAI and lung function impairment in the Chinese population. The VAI could be a simple and reliable approach in daily practice, and individuals, especially women with a high VAI, should receive additional screening and preventive interventions for respiratory disease.

Association between visceral adiposity index and kidney stones in American adults: A cross-sectional analysis of NHANES 2007–2018

“…Reportedly, VAI has the potential value of identifying metabolic disorder syndromes ( 17 ). VAI even plays an important role in assessing ED, lung function, cardiovascular diseases, diabetes, chronic kidney disease (CKD), and the degree of hepatic steatosis ( 10 , 13 , 18 – 21 ).…”

“…The major exposure factor was the VAI, and its value was used as the primary variable. VAI was calculated based on the sex-specific mathematical model: VAI = for women, and VAI = for men ( 13 ). The values of VAI calculated thereby are listed in Table 1 .…”

Visceral Obesity in Non-Small Cell Lung Cancer

“…Besides surveying CT-based visceral fat measurements and associating them with some important demographic and pathological variables in NSCLC, our study demonstrates the practicability and encourages the use of routine CT data to include visceral obesity as an examined factor in lung cancer research. Visceral adiposity is also of relevance in immediate clinical care of lung cancer for its influence on pulmonary function [ 30 ] and outcomes such as post-pneumonectomy complications [ 31 ] and radiation pneumonitis [ 32 ].…”

Nonlinear relationship between visceral adiposity index and lung function: a population-based study

“…Most previous studies have suggested an inverse relationship between obesity and changes in lung function [ 13 , 16 ]. However, it is essential to note that most studies have only compared lung function in overweight or obese people with average weight [ 14 , 16 , 20 ], ignoring the possible effects of low body fat on lung function.…”

“…Most of the studies that have been done to correlate with impaired lung function have been linear studies with increases or decreases [ 13 – 16 ]. However, in real-world biomedical research, the influence of many research factors on outcome variables is not a simple linear relationship but exists the phenomenon of a threshold effect.…”