Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease

Eguchi, Yuichiro; Eguchi, Takahisa; Mizuta, Toshihiko; Ide, Yasushi; Yasutake, Tsutomu; Iwakiri, Ryuichi; Hisatomi, Akitaka; Ozaki, Iwata; Yamamoto, Kei; Kitajima, Yoichiro; Kawaguchi, Yasunori; Kuroki, Shigetaka; Ono, Naofumi

doi:10.1007/s00535-006-1790-5

Cited by 258 publications

(240 citation statements)

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“…40,41 Regardless of BMI, central adiposity has been shown to be associated with NAFLD in normal weight, obese and diabetic individuals. 17,42,43 As the presence of PHT is related to the degree of steatosis, and as the degree of steatosis is related to the amount of visceral fat, the predictive role of waist circumference can easily be understood. Even after correction for the degree of steatosis, however, waist circumference remains an independent predictor of PTH, indicating that the relation between waist and steatosis-associated PTH cannot be fully explained by steatosis alone.…”

Section: Discussionmentioning

confidence: 99%

“…46,47,52 Previous studies showed that that the severity of fatty liver was positively correlated with visceral fat accumulation and insulin resistance. 42,48 However, the exact causal relation between IR, visceral fat and steatosis remains unclear. Furthermore, there are patients with IR and NAFLD who are not obese, indicating that other factors besides visceral obesity contribute to the association between NAFLD and IR.…”

Section: Discussionmentioning

confidence: 99%

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Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension

et al. 2010

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Introduction: We previously demonstrated in an animal model that steatosis, in the absence of fibrosis, induces a significant rise in portal pressure, indicating substantial changes in liver hemodynamics. As assessment of portal pressure is an invasive procedure, non-invasive parameters are needed to identify patients at risk. Aims: To study the portal pressure in nonalcoholic fatty liver disease patients and to identify factors that are possibly related to steatosis-induced changes in liver hemodynamics. Materials and methods: Patients presenting with a problem of overweight or obesity, and in whom non-invasive investigations showed signs of liver involvement, were proposed for transjugular hepatic vein catheterization and liver biopsy. The biopsy was scored according to the Nonalcoholic Steatohepatitis Clinical Research Network Scoring System. Results: A total of 50 consecutive patients were studied. Their mean age was 47.9 ± 1.8 years; 31 (62%) were female. Hepatic venous pressure gradient was normal in 36 (72%) and elevated in 14 (28%) patients. The degree of steatosis was the only histological parameter that differed significantly between the two groups (P ¼ 0.016), and was a predictor of the presence of portal hypertension (PHT) in regression analysis (P ¼ 0.010). Comparing normal versus portal hypertensive patients, waist circumference (117 ± 2 versus 128 ± 4 cm, P ¼ 0.005), waist-hip ratio (0.96 ± 0.06 versus 1.04 ± 0.03, P ¼ 0.003), visceral fat (229 ± 15 versus 292 ± 35 cm 2 , P ¼ 0.022), fasting insulin (15.4 ± 1.7 versus 21.8 ± 2.4 mU ml À1 , P ¼ 0.032), fasting c-peptide (1.22 ± 0.06 versus 1.49 ± 0.09 nmol l À1 , P ¼ 0.035) and homeostasis model assessment-insulin resistance (HOMA IR) (3.28 ± 0.29 versus 4.81 ± 0.57, P ¼ 0.019) were significantly higher. Age, gender, liver enzymes, ferritin and high-sensitive C-reactive protein were not significantly different. In regression analysis, waist circumference (P ¼ 0.008) and HOMA IR (P ¼ 0.043) were independent predictors of PHT. Conclusions: Estimates of both visceral adiposity and IR are predictors for the presence of PHT, related to the degree of steatosis, and may help in identifying patients who are at risk of developing steatosis-related complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension

et al. 2010

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“…Furthermore, Kwon et al, found that the differences in the amount of visceral fat between individuals with NAFLD and those without NAFLD may be greater in the non-obese group than in the obese group (Kwon et al, 2012). This suggests that visceral fat could be used as an important predictive factor for the development of NAFLD (Eguchi et al, 2006).…”

Section: Nafld: the Liver Manifestation Of Metsmentioning

confidence: 99%

“…Plasma free fatty acids are largely released by white adipose tissue when insulin resistance develops. Indeed, insulin resistance in this tissue results in increased lipolysis, which leads to high levels of circulating fatty acids ( Fig.1) (Eguchi et al, 2006). Altogether, hepatic fat accumulation causes NAFLD, subsequently leading to hepatic insulin resistance.…”

Section: Insulin Resistance: a Critical Node Between Mets And Nafldmentioning

confidence: 99%

Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

Asrih

Jornayvaz

2015

Molecular and Cellular Endocrinology

278

196

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“…In accordance with our findings, a previous study performed in Japan demonstrated that the severity of fatty liver, assessed by ultrasonography, was correlated with visceral fat accumulation and insulin resistance. 14 Chronic ALT elevation is considered to be a marker of hepatocyte damage. Increased ALT activity was associated with the MS, and this association was graded across a number of metabolic components.…”

Section: Discussionmentioning

confidence: 99%

1296 Visceral Adipose Tissue Area as an Independent Risk Factor of Elevated Liver Enzyme in Nonalcoholic Fatty Liver Disease

Kim¹,

Kim²,

Chung³

et al. 2012

Journal of Hepatology

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Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease

Cited by 258 publications

References 28 publications

Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension

Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension

Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

1296 Visceral Adipose Tissue Area as an Independent Risk Factor of Elevated Liver Enzyme in Nonalcoholic Fatty Liver Disease

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