Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor–α and negatively with adiponectin levels in obese adolescents

Lira, Fábio Santos; Rosa, José César; Santos, R; Venâncio, Daniel Paulino; Carnier, June; Sanches, Priscila de Lima; Nascimento, Cláudia Maria Oller do; Piano, Aline de; Tock, Lian; Tufik, Sérgio; Mello, Marco Túlio de; Dâmaso, Ana Raimunda; Oyama, Lila Missae

doi:10.1016/j.metabol.2010.02.017

Cited by 62 publications

(56 citation statements)

References 39 publications

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“…Several studies show that exercise training decreases insulin resistance and improves glucose control and diabetes, concomitantly increasing the adiponectin levels and the protein expression of insulin receptors in the skeletal muscle [18,38-40]. These effects were observed in the present study after 3 months of exercise training, but were no longer evident after 6 months.…”

Section: Discussionsupporting

confidence: 59%

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Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

et al. 2011

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Aging and physical inactivity are two factors that favors the development of cardiovascular disease, metabolic syndrome, obesity, diabetes, and sleep dysfunction. In contrast, the adoption a habitual of moderate exercise may present a non-pharmacological treatment alternative for sleep and metabolic disorders. We aimed to assess the effects of moderate exercise training on sleep quality and on the metabolic profile of elderly people with a sedentary lifestyle. Fourteen male sedentary, healthy, elderly volunteers performed moderate training for 60 minutes/day, 3 days/week for 24 wk at a work rate equivalent to the ventilatory aerobic threshold. The environment was kept at a temperature of 23 ± 2°C, with an air humidity 60 ± 5%. Blood and polysomnographs analysis were collected 3 times: at baseline (1 week before training began), 3 and 6 months (after 3 and 6 months of training). Training promoted increasing aerobic capacity (relative VO2, time and velocity to VO2max; p < 0.05), and reduced serum NEFA, and insulin concentrations as well as improved HOMA index (p < 0.05), and increased adiponectin levels (p < 0.05), after 3 months of training when compared with baseline data. The sleep parameters, awake time and REM sleep latency were decreased after 6 months exercise training (p < 0.05) in relation baseline values. Our results demonstrate that the moderate exercise training protocol improves the sleep profile in older people, but the metabolism adaptation does not persist. Suggesting that this population requires training strategy modifications as to ensure consistent alterations regarding metabolism.

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Section: Discussionsupporting

confidence: 59%

“…On the other hand, acute and chronic exercise may be an option of non-pharmacological treatment for metabolic dysfunction and sleep disorders [12,16-18], especially in older individuals [19]. These effects promoted by exercise training are intensity, volume and duration dependent [20].…”

Section: Introductionmentioning

confidence: 99%

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

et al. 2011

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“…Indeed, increased abdominal obesity has been associated with lower levels of adiponectin [1,25,39,40] and adiponectin was negatively associated with visceral-to-subcutaneous fat ratio [41]. The association between hypoadiponectinaemia and increased visceral adipose tissue (VAT) seems to appear early in life [33].…”

Section: Adiponectin and The Risk Of Developing Co-morbiditiesmentioning

confidence: 99%

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

Nascimento¹,

Coimbra²,

Rêgo³

et al. 2017

Adiposity - Omics and Molecular Understanding

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Paediatric obesity has significant physic, social and psychological implications. Childhood obesity is usually associated in adulthood with increased risk of type 2 diabetes, metabolic syndrome and cardiovascular diseases. Aggregation of cardiometabolic risk factors is already observed at young ages, with a nonlinear association with enhancement of adiposity. Adiponectin is an adipokine that inhibits inflammation, oxidative stress and metabolic syndrome components, namely dyslipidaemia, high blood pressure and insulin resistance. Obesity has been associated with hypoadiponectinaemia in both adult and paediatric patients, which may contribute to co-morbidities observed in these patients. Interventional studies that aim to tackle obesity reported controversial results. Although the general positive effect on weight loss, inflammatory and cardiometabolic markers has been studied, the impact of these interventional studies on adiponectin remains unclear. Some studies reported that the improvement in adiponectin might only occur in paediatric obese patients with great weight loss or intensive physical exercise; the magnitude of the changes in body composition appears to be of particular importance. A revision about the knowledge on the relation between adiponectin, inflammation and cardiometabolic risk factors in paediatric patients is performed; the impact of interventional studies on adiponectin levels and markers of cardiometabolic risk is also addressed.

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“…IL-6 is primarily modulated by the transcription factor NF-κB, and is positively correlated with levels of obesity [62]. IL-6 has typically been associated with cardiovascular diseases, morbidity, and physical frailty.…”

Section: Obesity Systemic Inflammation and Low Back Painmentioning

confidence: 99%

Obesity and Low Back Pain: Is There a Weight of Evidence to Support a Positive Relationship?

et al. 2013

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Obesity and low back pain (LBP) are responsible for significant morbidities and financial expenditure. Numerous studies have demonstrated a positive relationship between obesity and LBP, but a concurrent investigation of causality is often omitted. Spinal clinicians routinely prescribe exercise and weight loss for obese patients with LBP, despite a paucity of literature evaluating why obesity might cause LBP or how exercise and weight loss might be suitable treatments for LBP. Etiologies have tended to focus on the biomechanical effects of obesity that lead to excessive loading and degeneration of the lumbar spine. However, recent evidence suggests that systemic inflammation associated with obesity may also be an important contributor to LBP. In this article, the latest evidence investigating the relationship between obesity and LBP is reviewed, an overview of the impact of exercise and weight loss on LBP is provided, and proposed mechanisms connecting obesity, systemic inflammation, and LBP are outlined.

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Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor–α and negatively with adiponectin levels in obese adolescents

Cited by 62 publications

References 39 publications

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

Obesity and Low Back Pain: Is There a Weight of Evidence to Support a Positive Relationship?

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