Visceral fat might impact left ventricular remodeling through changes in arterial stiffness in type 2 diabetes: A cross-sectional study

Huang, Haishan; Jin, Jing; Chen, Yanshan; Wang, Lina; Zhong, Jingyi; Chen, Zhenguo; Xu, Lei

doi:10.1016/j.ijcard.2022.08.033

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…VFA and SFA were measured by a trained physician using a dual BIA (HDS-2000 DUALSCAN; Omron Healthcare, Kyoto, Japan) after subjects had fasted for at least 12 h [ 17 ]. The gadget measures the surface impedance of the body and the torso using a bioelectrical impedance assembly, and it also includes an abdominal dimension measurement device.…”

Section: Methodsmentioning

confidence: 99%

Visceral fat area is more strongly associated with arterial stiffness than abdominal subcutaneous fat area in Chinese patients with type 2 diabetes

Mao,

Gan,

Gong

et al. 2024

Diabetol Metab Syndr

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Background Few studies have compared the correlation between visceral fat area (VFA) and abdominal subcutaneous fat area (SFA) with arterial stiffness (AS) in patients with type 2 diabetes (T2D). In addition, there is currently controversy regarding the correlation between VFA and SFA with AS. We aimed to investigate the relationship between VFA and SFA with AS in patients with T2D. Methods In this cross-sectional study, 1475 Chinese T2D patients with an average age of 52.32 ± 10.96 years were included. VFA and SFA were determined by a dual bioelectrical impedance analyzer, and AS was determined by measurement of brachial-ankle pulse wave conduction velocity (baPWV). Atherosclerosis was deemed present in study participants with baPWV values higher than 75th percentile (1781 cm/s). Independent correlations of logVFA and logSFA with AS were assessed using multiple linear regression and multivariate logistic regression. Results The baPWV was linked with VFA, waist circumference, and women’s SFA in a general linear correlation study (P < 0.05), but not with body mass index (P = 0.3783) or men’s SFA (P = 0.1899). In both men and women, VFA and SFA were positively correlated with AS, according to the generalized additive model (GAM). After fully adjusting for confounders, multiple linear regression analyses showed that for every 1-unit increase in logVFA, the beta coefficient of baPWV increased by 63.1 cm/s (95% CI: 18.4, 107.8) (P < 0.05). logSFA did not correlate significantly with baPWV (P = 0.125). In the multiple logistic regression analysis, the odds ratio (OR) of elevated baPWV was 1.8 (95% CI: 1.1, 3.1) (P = 0.019) per 1-unit increase in logVFA. logSFA did not correlate significantly with AS (P = 0.091). In the subgroup analysis, the correlation between logVFA and baPWV did not interact across subgroups (P-interaction > 0.05). Conclusions Compared with SFA, VFA had a stronger independent positive correlation with AS in Chinese T2D patients. Patients with T2D should pay more attention to monitoring VFA and lowering it to minimize cardiovascular events.

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Section: Methodsmentioning

confidence: 99%

Visceral fat area is more strongly associated with arterial stiffness than abdominal subcutaneous fat area in Chinese patients with type 2 diabetes

Mao,

Gan,

Gong

et al. 2024

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…Diabetes is an important risk factor for vascular remodeling, which can cause extracellular matrix changes, eventually leading to arterial remodeling and arterial stiffness (17,18). It has been reported that arterial stiffness is greater in patients with diabetes than in individuals without diabetes (19,20). Zhang et al observed that reactive oxygen species were significantly elevated in the arteries of STZ-induced diabetic rats, and oxidative stress can lead to deposition of collagen and arterial fibrosis (21).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estimated pulse wave velocity is associated with all-cause mortality and cardiovascular mortality among adults with diabetes

Chu

Kong

et al. 2023

Front. Cardiovasc. Med.

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AimsWe aim to examine the association of estimated pulse wave velocity (ePWV) with all-cause and cardiovascular mortality in patients with diabetes.MethodsAll of adult participants with diabetes from the National Health and Nutrition Examination Survey (NHANES) (1999–2018) were enrolled. ePWV was calculated according to the previously published equation based on age and mean blood pressure. The mortality information was obtained from the National Death Index database. Weighted Kaplan-Meier (KM) plot and weighted multivariable Cox regression was used to investigate the association of ePWV with all-cause and cardiovascular mortality risks. Restricted cubic spline was adopted to visualize the relationship between ePWV and mortality risks.Results8,916 participants with diabetes were included in this study and the median follow-up duration was ten years. The mean age of study population was 59.0 ± 11.6 years, 51.3% of the participants were male, representing 27.4 million patients with diabetes in weighted analysis. The increment of ePWV was closely associated with increased risks of all-cause mortality (HR: 1.46, 95% CI: 1.42–1.51) and cardiovascular mortality (HR: 1.59, 95% CI: 1.50–1.68). After adjusting for cofounding factors, for every 1 m/s increase in ePWV, there was a 43% increased risk of all-cause mortality (HR: 1.43, 95% CI: 1.38–1.47) and 58% increased of cardiovascular mortality (HR: 1.58, 95% CI: 1.50–1.68). ePWV had positive linear associations with all-cause and cardiovascular mortality. KM plots also showed that the risks of all-cause and cardiovascular mortality were significantly elevated in patients with higher ePWV.ConclusionsePWV had a close association with all-cause and cardiovascular mortality risks in patients with diabetes.

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The risk factors of early arterial stiffness in type 2 diabetes without diabetic macroangiopathy

Wu,

Wang,

Jia

et al. 2023

Int J Diabetes Dev Ctries

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Visceral fat might impact left ventricular remodeling through changes in arterial stiffness in type 2 diabetes: A cross-sectional study

Cited by 7 publications

References 44 publications

Visceral fat area is more strongly associated with arterial stiffness than abdominal subcutaneous fat area in Chinese patients with type 2 diabetes

Visceral fat area is more strongly associated with arterial stiffness than abdominal subcutaneous fat area in Chinese patients with type 2 diabetes

Estimated pulse wave velocity is associated with all-cause mortality and cardiovascular mortality among adults with diabetes

The risk factors of early arterial stiffness in type 2 diabetes without diabetic macroangiopathy

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