Visceral hypersensitivity: facts, speculations, and challenges

Camilleri, Michael; Coulie, Bernard; Tack, Jan

doi:10.1136/gut.48.1.125

Cited by 185 publications

(144 citation statements)

References 63 publications

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“…36 Several studies have confirmed that, as a group, patients with functional dyspepsia have enhanced sensitivity to balloon distension of the proximal stomach. 12,35,[37][38][39][40] It is now clear that hypersensitivity to distension is present in only a subset of patients.…”

Section: Hypersensitivity To Gastric Distensionmentioning

confidence: 96%

Pathophysiology and treatment of functional dyspepsia

2004

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Section: Hypersensitivity To Gastric Distensionmentioning

confidence: 96%

Pathophysiology and treatment of functional dyspepsia

2004

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“…9 In addition, specific hypersensitivity to colorectal distension is far from consistent, and has only been reported in 20-80% of IBS patients across studies. 10 In the remainder of patients, colorectal sensitivity appears to be normal. It has previously been suggested that IBS patients with visceral hypersensitivity and IBS patients with normal sensitivity may represent different subpopulations with distinct pathophysiologies.…”

Section: Introductionmentioning

confidence: 99%

Relationship between symptoms and hypersensitivity to rectal distension in patients with irritable bowel syndrome

Kuiken¹,

Lindeboom

Tytgat³

et al. 2005

Aliment Pharmacol Ther

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SUMMARYBackground: Visceral hypersensitivity is considered an important pathophysiological mechanism in irritable bowel syndrome, yet its relationship to symptoms is unclear. Aim: To detect possible associations between symptoms and the presence of hypersensitivity to rectal distension in patients with irritable bowel syndrome. Methods: Ninety-two irritable bowel syndrome patients and 17 healthy volunteers underwent a rectal barostat study. The association between specific irritable bowel syndrome symptoms and the presence of hypersensitivity was examined using Area under the Receiver Operating Characteristic curves. Results: Irritable bowel syndrome patients had significantly lower thresholds for discomfort/pain than healthy volunteers: 24 (18-30) and 30 (27-45) mmHg above minimal distending pressure, respectively. Forty-

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“…8 Of various pathogenetic factors, visceral hypersensitivity is common to most patients with IBS. [9][10][11] Visceral hypersensitivity may result from abnormal cerebral processing of peripheral visceral sensation. The existence of visceral hypersensitivity in IBS patients has been evidenced by finding lower pain threshold to various kinds of painful stimuli like rectal distension compared with controls.…”

Section: Introductionmentioning

confidence: 99%

Mapping of Brain Activations to Rectal Balloon Distension Stimuli in Male Patients with Irritable Bowel Syndrome Using Functional Magnetic Resonance Imaging

Guleria

Karyampudi

Singh

et al. 2017

J Neurogastroenterol Motil

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Background/AimsIrritable bowel syndrome (IBS) is associated with exaggerated cerebral response including emotional processing following visceral stimulation; though data on this issue is available in female IBS patients, it is scanty among males. Hence, we aimed to study brain response of male IBS patients following rectal balloon distension as compared to healthy controls using functional magnetic resonance imaging (fMRI). Data between diarrhea and constipation predominant IBS (IBS-D and IBS-C) were also compared. MethodsRectal balloon distension threshold was assessed in 20 male IBS patients (10 IBS-C and 10 IBS-D) and 10 age-matched male healthy controls. Subsequently, fMRI on all the participants was performed at their respective rectal pain threshold. The fMRI data were analysed using the Statistical Parametric Mapping software. ResultsIBS patients showed greater cerebral activations in insula, middle temporal gyrus, and cerebellum in the left hemisphere compared to healthy controls. Neural activation was found in bilateral precuneus/superior parietal lobules in controls but not in patients with IBS. The brain activation differed among IBS-C and IBS-D patients; while the right mid-cingulate cortex was activated in IBS-C, the left inferior orbito-frontal cortex, left calcarine, and bilateral fusiform gyri were activated among patients with IBS-D following rectal balloon distension. Conclusions

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Visceral hypersensitivity: facts, speculations, and challenges

Cited by 185 publications

References 63 publications

Pathophysiology and treatment of functional dyspepsia

Pathophysiology and treatment of functional dyspepsia

Relationship between symptoms and hypersensitivity to rectal distension in patients with irritable bowel syndrome

Mapping of Brain Activations to Rectal Balloon Distension Stimuli in Male Patients with Irritable Bowel Syndrome Using Functional Magnetic Resonance Imaging

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