Visceral Leishmaniasis Turning into Chronic Liver Disease

Epstein, Jenny; Ry, Kirdani

doi:10.3329/jom.v17i1.30063

Cited by 1 publication

(1 citation statement)

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“…Furthermore, different case reports supported the present study and reported liver dysfunction with the raised value of serum AST, ALT, and bilirubin from VL patients. [14][15][16][17][18][19] Similarly, studies conducted in India and Bangladesh also reported abnormally high liver inflammatory enzymes like ALT, AST, and ALP in VL patients. 6,20 This may be attributed to the levels of particular circulating cytokines during the inflammatory processes observed in active VL disease could be a determinant and consequence of severe liver disease.…”

Section: Discussionmentioning

confidence: 99%

<p>Alteration of Clinical Chemistry Parameters Among Visceral Leishmaniasis Patients in Western Tigrai, Ethiopia, 2018/2019: A Comparative Cross-Sectional Study</p>

Tesfanchal

Gebremichail

Belay

et al. 2020

IDR

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Background: Visceral leishmaniasis causes alterations of lipid metabolism and it is associated with hypocholesterolemia and severe hypertriglyceridemia. Hepatic dysfunction and life-threatening hepatitis are associated with visceral leishmaniasis. Kidney damage is frequently associated with increased morbidity and mortality in visceral leishmaniasis patients. Methods: A cross-sectional study was carried out to assess the alterations of clinical chemistry parameters among visceral leishmaniasis patients attending Kahsay Abera and Mearg hospitals, Northwest Ethiopia. A total of 100 visceral leishmaniasis patients and 100 healthy controls without visceral leishmaniasis were selected by using convenient sampling techniques. Data were entered and analyzed using statistical package for social sciences (SPSS) version 23. Results: Results were showed that the mean value of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, and triglyceride was significantly higher in visceral leishmaniasis patients than in apparently healthy controls, but the mean value of serum urea and total cholesterol was significantly lower in visceral leishmaniasis patients than healthy controls. Conclusion: The finding of this study concluded that visceral leishmaniasis causes significant alterations of clinical chemistry tests like liver and lipid profile tests compared to healthy controls.

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