Viscerosomatic convergence and responses to intestinal distension of neurons at the junction of midbrain and posterior thalamus in the cat

Carstens, Earl; Yokota, T.

doi:10.1016/0014-4886(80)90036-9

Cited by 20 publications

(8 citation statements)

References 35 publications

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“…In previous electrophysiological studies, nociceptive responses have been recorded in the posterior thalamic group (for review see Albe-Fessard et al, 1985;Poggio and Mountcastle, 1960;Carstens and Yokota, 1980;Guilbaud et al, 1980;Peschanski et al, 1981), the intralaminar thalamic nuclei , the medial thalamic nuclei (Dostrovsky and Guilbaud, 1990), the SPFPC (Dong et al, 1978), and the lateral habenular nucleus (Benabid and Jeaugey, 1989). Most of the neurons in the intralaminar nuclei respond exclusively to noxious somatic and visceral stimuli (Peschanski et al, 1981;.…”

Section: Functional Considerationsmentioning

confidence: 97%

Ascending projections from the area around the spinal cord central canal: APhaseolus vulgaris leucoagglutinin study in rats

Wang¹,

Willis²,

Westlund³

1999

J. Comp. Neurol.

118

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Section: Functional Considerationsmentioning

confidence: 97%

Ascending projections from the area around the spinal cord central canal: APhaseolus vulgaris leucoagglutinin study in rats

Wang¹,

Willis²,

Westlund³

1999

J. Comp. Neurol.

118

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“…Perhaps most importantly, and most strikingly different from the MGv, the MGm is highly multimodal, consistent with its diverse inputs. In addition to its major auditory character, cells in the MGm respond to tactile, thermal, nociceptive, vestibular and visceral stimulation (Blum et al, 1979; Brinkhus et al, 1979; Carstens and Yokota, 1980; Khorevin, 1980; Love and Scott, 1969; Wepsic, 1966). Single neurons in the MGm exhibit convergence of tone and footshock stimulation (Bordi and LeDoux, 1994a, 1994b).…”

Section: Relevant Anatomy and Physiology Of The Medial Geniculate mentioning

confidence: 99%

The medial geniculate, not the amygdala, as the root of auditory fear conditioning

2011

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The neural basis of auditory fear conditioning (AFC) is almost universally believed to be the amygdala, where auditory fear memories are reputedly acquired and stored. This widely-accepted amygdala model holds that that the auditory conditioned stimulus (CS) and the nociceptive unconditioned stimulus (US) first converge in the lateral nucleus of the amygdala (AL), and are projected independently to it from the medial division of the medial geniculate nucleus (MGm) and the adjacent posterior intralaminar nucleus (PIN), which serve merely as sensory relays. However, the four criteria that are used to support the AL model, (a) CS-US convergence, (b) associative plasticity, (c) LTP and (d) lesion-induced learning impairment, are also met by the MGm/PIN. Synaptic and molecular approaches supporting the AL also implicate the MGm/PIN. As both the AL and its preceding MGm/PIN are critically involved, we propose that the latter be considered the "root" of AFC.

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“…For example, the most studied function of the medial geniculate nucleus (MGN) is its role in passing auditory information from the inferior colliculus to the auditory cortex (Budinger et al, 2000; Crippa et al, 2010; Geiser et al, 2012; Horie et al, 2013; Jones, 1985; Llano and Sherman, 2008; Mesulam and Pandya, 1973; Monakow, 1914; Poliak, 1926; Redies et al, 1989; Ryugo and Killackey, 1974; Tunturi, 1946; Walker, 1937). However, there is also evidence the MGN has a far broader role in multisensory processing (Blum et al, 1979; Brinkhus et al, 1979; Carstens and Yokota, 1980; Love and Scott, 1969; Wepsic, 1966). Further, there is growing evidence that the MGN does not operate in isolation from other posterior thalamic nuclei (i.e.…”

Section: Introductionmentioning

confidence: 99%

A comparative analysis of mouse and human medial geniculate nucleus connectivity: A DTI and anterograde tracing study

et al. 2015

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Understanding the function and connectivity of thalamic nuclei is critical for understanding normal and pathological brain function. The medial geniculate nucleus (MGN) has been studied mostly in the context of auditory processing and its connection to the auditory cortex. However, there is a growing body of evidence that the MGN and surrounding associated areas (‘MGN/S’) have a diversity of projections including those to the globus pallidus, caudate/putamen, amygdala, hypothalamus, and thalamus. Concomitantly, pathways projecting to the medial geniculate include not only the inferior colliculus but also the auditory cortex, insula, cerebellum, and globus pallidus. Here we expand our understanding of the connectivity of the MGN/S by using comparative diffusion weighted imaging with probabilistic tractography in both human and mouse brains (most previous work was in rats). In doing so, we provide the first report that attempts to match probabilistic tractography results between human and mice. Additionally, we provide anterograde tracing results for the mouse brain, which corroborate the probabilistic tractography findings. Overall, the study provides evidence for the homology of MGN/S patterns of connectivity across species for understanding translational approaches to thalamic connectivity and function. Further, it points to the utility of DTI in both human studies and small animal modeling, and it suggests potential roles of these connections in human cognition, behavior, and disease.

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Viscerosomatic convergence and responses to intestinal distension of neurons at the junction of midbrain and posterior thalamus in the cat

Cited by 20 publications

References 35 publications

Ascending projections from the area around the spinal cord central canal: APhaseolus vulgaris leucoagglutinin study in rats

Ascending projections from the area around the spinal cord central canal: APhaseolus vulgaris leucoagglutinin study in rats

The medial geniculate, not the amygdala, as the root of auditory fear conditioning

A comparative analysis of mouse and human medial geniculate nucleus connectivity: A DTI and anterograde tracing study

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