The brittle‐ductile transition is a domain of finite extent characterized by high differential stress where both brittle and ductile deformation are likely to occur. Understanding its depth location, extent, and stability through time is of relevance for diverse applications including subduction dynamics, mantle‐surface interactions, and, more recently, proper targeting of high‐enthalpy unconventional geothermal resources, where local thermal conditions may activate ductile creep at shallower depths than expected. In this contribution, we describe a thermodynamically consistent physical framework and its numerical implementation, therefore extending the formulation of the companion paper Jacquey and Cacace (2020, https://doi.org/10.1029/2019JB018474) to model thermo‐hydro‐mechanical coupled processes responsible for the occurrence of transitional semi‐brittle, semi‐ductile behavior in porous rocks. We make use of a damage rheology to account for the macroscopic effects of microstructural processes leading to brittle‐like material weakening and of a rate‐dependent plastic model to account for ductile material behavior. Our formulation additionally considers the role of porosity and its evolution during loading in controlling the volumetric mechanical response of a stressed rock. By means of dedicated applications, we discuss how our damage poro‐visco‐elasto‐viscoplastic rheology can effectively reconcile the style of localized deformation under different confining pressure conditions as well as the bulk macroscopic material response as recorded by laboratory experiments under full triaxial conditions.