Viscoelastic Characteristics of In Vitro Vital and Devitalized Rat Aorta and Human Arterial Prostheses

Antonova, M.; Antonov, P.; Маринов, Г.; Vlaskovska, Mila; Kasakov, L.

doi:10.1007/s10439-008-9477-0

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…Results from more recent studies on the frequency dependency of arterial wall viscosity have not resulted in a convergence in findings. Although some investigators have found that wall viscosity decreases with HR with no change in arterial stiffness, 35 others have found that, at higher frequencies, in the range of HRs tested in this study (300 -450 oscillations per minute), the rat aorta wall may become more susceptible to stiffening, 36 especially at higher pressures. 33 Our finding that the effect of HR on PWV was more evident at higher MAP is consistent with the latter observation.…”

Section: Tan Et Al Heart Rate Dependency Of Aortic Stiffnesscontrasting

confidence: 54%

Heart Rate Dependence of Aortic Pulse Wave Velocity at Different Arterial Pressures in Rats

et al. 2012

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Abstract-Arterial stiffness, as measured by aortic pulse wave velocity (PWV), is an independent marker of cardiovascular disease and events in both healthy and diseased populations. Although some cardiovascular risk factors, such as age and blood pressure, show a strong association with PWV, the association between heart rate (HR) and PWV is not firmly established. Furthermore, this association has not been investigated at different arterial blood pressures. To study effects of HR on aortic PWV at different mean arterial pressures (MAPs), adult (12 weeks; nϭ7), male, anesthetized Sprague-Dawley rats were randomly paced at HRs of between 300 and 450 bpm, at 50-bpm steps. At each pacing step, aortic PWV was measured across a physiological MAP range of 60 to 150 mmHg by infusing sodium nitroprusside and phenylephrine. When compared at the same MAP, increases in HR resulted in significant increases in PWV at all of the MAPs Ͼ80 mmHg (ANOVA, PϽ0.05), with the greatest significant change of 6.03Ϯ0.93% observed in the range 110 to 130 mmHg. The positive significant association between HR and PWV remained when PWV was adjusted for MAP (ANOVA, PϽ0.001). These results indicate that HR dependency of PWV is different at higher pressures than at lower pressures and that HR may be a confounding factor that should be taken into consideration when performing analysis based on PWV measurements. (Hypertension. 2012;60:528-533.)

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Section: Tan Et Al Heart Rate Dependency Of Aortic Stiffnesscontrasting

confidence: 54%

Heart Rate Dependence of Aortic Pulse Wave Velocity at Different Arterial Pressures in Rats

et al. 2012

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“…Large elastic arteries such as the aorta exhibit nonlinear blood pressure-dependent mechanical wall behavior [1][2][3]. The arterial wall exhibits both elastic and viscous properties at the same time.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Effects of Fentanyl on Aortic Viscoelasticity in a Rat Model of Melatonin Deficiency

Georgiev,

Kaneva,

Shikova

et al. 2024

Preprint

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Melatonin influences arterial biomechanics, and its absence could cause remodeling of the arterial wall, leading to increased stiffness. Direct effects of fentanyl on the aortic wall have also been observed previously. This study aimed to evaluate in vitro the effects of fentanyl on aortic viscoelasticity in a rat model of melatonin deficiency. It also aimed to test the hypothesis that melatonin deficiency leads to increased arterial wall stiffness. The viscoelasticity of the aortic wall was estimated in strip preparations from pinealectomised and sham-operated adult rats using the forced oscillations method. We found that melatonin deficiency in the untreated aortic wall did not significantly alter viscoelasticity. However, combined with 10-9 M fentanyl, melatonin deficiency increased the natural frequency and arterial stiffness compared to the sham-operated. Independently, fentanyl treatment decreased the natural frequency and arterial stiffness compared separately to untreated normal and melatonin-deficient preparations. The observed effects of fentanyl were neither dose-dependent nor affected by naloxone, suggesting a non-opioid mechanism. Furthermore, an independent effect of naloxone was also detected in the normal rat aortic wall, resulting in reduced arterial stiffness. Further studies are needed to clarify the underlying mechanisms, which may improve the clinical decisions for pain management and anesthesia.

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“…Large elastic arteries such as the aorta exhibit nonlinear blood pressure-dependent mechanical wall behavior [ 1 , 2 , 3 ]. It possesses both elastic and viscous properties at the same time.…”

Section: Introductionmentioning

confidence: 99%

“…Such mechanical behavior is referred to as viscoelastic, and its characteristics are often considered as measures of arterial stiffness and compliance. The biomechanical properties of the aorta have been studied extensively over the past few decades using various methods [ 1 , 3 , 4 , 5 ]. Without nervous and humoral regulation by the organism, the direct basal viscoelasticity assessment is performed in vitro using partial or cylindrical arterial segments [ 2 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Effects of Fentanyl on Aortic Viscoelasticity in a Rat Model of Melatonin Deficiency

Georgiev,

Kaneva,

Shikova

et al. 2024

IJMS

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Melatonin influences arterial biomechanics, and its absence could cause remodeling of the arterial wall, leading to increased stiffness. Direct effects of fentanyl on the aortic wall have also been observed previously. This study aimed to evaluate in vitro the effects of fentanyl on aortic viscoelasticity in a rat model of melatonin deficiency and to test the hypothesis that melatonin deficiency leads to increased arterial wall stiffness. The viscoelasticity was estimated in strip preparations from pinealectomized (pin, melatonin deficiency) and sham-operated (sham, normal melatonin) adult rats using the forced oscillations method. In the untreated aortic wall pin, the viscoelasticity was not significantly altered. However, combined with 10−9 M fentanyl, the pin increased the natural frequency (f0) and modulus of elasticity (E’) compared to the sham-operated. Independently, fentanyl treatment decreased f0 and E’ compared separately to untreated sham and pin preparations. The effects of fentanyl were neither dose-dependent nor affected by naloxone, suggesting a non-opioid mechanism. Furthermore, an independent effect of naloxone was also detected in the normal rat aortic wall, resulting in reduced E’. Additional studies are needed that may improve the clinical decisions for pain management and anesthesia for certain patients with co-occurring chronic low levels of blood plasma melatonin and some diseases.

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Viscoelastic Characteristics of In Vitro Vital and Devitalized Rat Aorta and Human Arterial Prostheses

Cited by 9 publications

References 20 publications

Heart Rate Dependence of Aortic Pulse Wave Velocity at Different Arterial Pressures in Rats

Heart Rate Dependence of Aortic Pulse Wave Velocity at Different Arterial Pressures in Rats

In Vitro Effects of Fentanyl on Aortic Viscoelasticity in a Rat Model of Melatonin Deficiency

In Vitro Effects of Fentanyl on Aortic Viscoelasticity in a Rat Model of Melatonin Deficiency

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