Viscoelastic characterization of<i>in vitro</i>canine tissue

Kiss, Miklós; Varghese, Tomy; Hall, Timothy J.

doi:10.1088/0031-9155/49/18/002

Cited by 147 publications

(71 citation statements)

References 31 publications

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“…The resonance frequency and the magnitude of the electromechanical impedance of a PZTembedded structure at the resonance frequency depend on the density, elastic modulus and loss factor of the surrounding medium. The elastic modulus and loss factor of the tissue increase due to ablation, thereby providing a method for monitoring tissue cauterization (Kiss et al 2004). Figure 5(a) shows the schematic of the modified Butterworth-Van-Dyke circuit.…”

Section: Tissue Ablation Modelmentioning

confidence: 99%

A biopsy tool with integrated piezoceramic elements for needle tract cauterization and cauterization monitoring

Visvanathan

Gianchandani

2011

Biomed Microdevices

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This paper reports the feasibility of biopsy needle tract cauterization and cauterization monitoring using an embedded array of piezoceramic microheaters. Circular heaters of lead zirconate titanate (PZT-5A), with 200 μm diameter and 70-80 μm thickness, are fabricated using a batch mode micro ultrasonic machining process. These are then assembled into cavities in the walls of 20-gauge stainless steel needles and sealed with epoxy. Experiments are performed by inserting the proposed biopsy needle into porcine tissue samples. The needle surface exceeds the minimum target temperature rise of 33°C for either radial or thickness mode vibrations. The corresponding input power levels are 236 mW and 325 mW, respectively. The tissue cauterization extends 1-1.25 mm beyond the perimeter of the needle and is uniform in all directions. After cauterization, the fundamental anti-resonance frequency and the corresponding impedance magnitude of the PZT heater decrease by 4.1% and 42.6%, respectively, thereby providing a method to monitor the extent of tissue cauterization. A sensing interface circuit capable of measuring the resonance frequency shift of the PZT elements is built and tested using discrete integrated circuit components. The circuit detects the resonance frequency shift from 8.22 MHz to 7.96 MHz of the PZT elements when the biopsy needle is inserted into wax medium. An interface circuit for actuation of the PZT elements for tissue cauterization is also described.

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Section: Tissue Ablation Modelmentioning

confidence: 99%

A biopsy tool with integrated piezoceramic elements for needle tract cauterization and cauterization monitoring

Visvanathan

Gianchandani

2011

Biomed Microdevices

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“…These models are used to show the relationship between the stress and strain that models the viscoelastic response of tissue and its structure. The standard rheological models like, Maxwell [33], Kelvin-Voigt model [33, 34, 35, 36] and standard linear solid models [33] are the most applicable ones. Sloninsky, et al [37] described a model called fractional derivative to model the behavior of biological tissue with lower number of fit parameters [38].…”

Section: Introductionmentioning

confidence: 99%

Automated Compression Device for Viscoelasticity Imaging

Nabavizadeh

Kinnick

Bayat

et al. 2017

IEEE Trans. Biomed. Eng.

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Non-invasive measurement of tissue viscoelastic properties is gaining more attention for screening and diagnostic purposes. Recently, measuring dynamic response of tissue under a constant force has been studied for estimation of tissue viscoelastic properties in terms of retardation times. The essential part of such a test is an instrument that is capable of creating a controlled axial force and is suitable for clinical applications. Such a device should be lightweight, portable and easy to use for patient studies to capture tissue dynamics under external stress. In this paper we present the design of an automated compression device for studying the creep response of materials with tissue-like behaviors. The device can be used to apply a ramp-and-hold force excitation for a predetermined duration of time and it houses an ultrasound probe for monitoring the creep response of the underlying tissue. To validate the performance of the device, several creep tests were performed on tissue-mimicking phantoms and the results were compared against those from a commercial mechanical testing instrument. Using a second order Kelvin-Voigt model and surface measurement of the forces and displacements, retardation times T1 and T2 were estimated from each test. These tests showed strong agreement between our automated compression device and the commercial mechanical testing system, with an average relative error of 2.9% and 12.4 %, for T1 and T2 respectively. Also, we present the application of compression device to measure local retardation times for four different phantoms with different size and stiffness.

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“…Recently, some models based on the fractional order derivative have been applied to biological tissue viscoelasticity [13,[16][17][18][19][20][21]. The fractional order derivative leads to a component called a spring-pot of order α which behaves between pure elastic and viscous materials.…”

Section: Introductionmentioning

confidence: 99%

A model of lung parenchyma stress relaxation using fractional viscoelasticity

Dai

Peng

Mansy

et al. 2015

Medical Engineering & Physics

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Some pulmonary diseases and injuries are believed to correlate with lung viscoelasticity changes. Hence, a better understanding of lung viscoelastic models could provide new perspectives on the progression of lung pathology and trauma. In the presented study, stress relaxation measurements were performed to quantify relaxation behavior of pig lungs. Results have uncovered certain trends, including an initial steep decay followed by a slow asymptotic relaxation, which would be better described by a power law than exponential decay. The fractional standard linear solid (FSLS) and two integer order viscoelastic models - standard linear solid (SLS) and generalized Maxwell (GM) - were used to fit the stress relaxation curves; the FSLS was found to be a better fit. It is suggested that fractional order viscoelastic models, which have nonlocal, multi-scale attributes and exhibit power law behavior, better capture the lung parenchyma viscoelastic behavior.

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Viscoelastic characterization ofin vitrocanine tissue

Cited by 147 publications

References 31 publications

A biopsy tool with integrated piezoceramic elements for needle tract cauterization and cauterization monitoring

A biopsy tool with integrated piezoceramic elements for needle tract cauterization and cauterization monitoring

Automated Compression Device for Viscoelasticity Imaging

A model of lung parenchyma stress relaxation using fractional viscoelasticity

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