Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils

Hammer, Maximilian; Muuss, Marcel; Herbster, Lorenz; Herth, Jonathan; Scheuerle, Alexander; Khoramnia, Ramin; Łabuz, Grzegorz; Uhl, Philipp; Auffarth, Gerd Uwe

doi:10.1167/tvst.13.7.5

Trans. Vis. Sci. Tech.

2024

DOI: 10.1167/tvst.13.7.5

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Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils

Maximilian Hammer,

Marcel Muuss,

Lorenz Herbster

et al.

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2024

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A review of human cornea finite element modeling: geometry modeling, constitutive modeling, and outlooks

Pang,

Wang,

Wang

et al. 2024

Front. Bioeng. Biotechnol.

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The cornea is a vital tissue of the human body. The health status of the cornea has a great impact on the quality life of person. There has been a great deal of research on the human cornea biomechancis. However, the difficulty in obtaining the human cornea has greatly limited the research of cornea biomechancis. Using finite element modelling has become a very effective and economical means for studying mechanical properties of human cornea. In this review, the geometrical and constitutive models of the cornea are summarised and analysed, respectively. Some factors affecting of the finite element calculation are discussed. In addition, prospects and challenges for the finite element model of the human cornea are presented. This review will be helpful to researchers performing studies in the relevant fields of human cornea finite element analysis.

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A review of human cornea finite element modeling: geometry modeling, constitutive modeling, and outlooks

Pang,

Wang,

Wang

et al. 2024

Front. Bioeng. Biotechnol.

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In Vitro Physicochemical and Pharmacokinetic Properties of Bevacizumab Dissolved in Silicone Oils Compared to Hydrogel-Substitutes and Porcine Vitreous Bodies

Hammer,

Herth,

Herbster

et al. 2024

Gels

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Anti-VEGF agents, e.g., bevacizumab, are used in retinal surgery, while their interaction with silicone oils and novel hydrogels remains unclear. This study examines the in vitro pharmacokinetics of bevacizumab in silicone oil-filled eyes compared to various hydrogel replacements and the porcine vitreous body as well as its impact on the interface tension of silicone oils. An in vitro model filled with light or heavy silicone oil, porcine vitreous bodies, or hydrogels (alginate and polyethylene glycol (PEG)-based) was equilibrated with a balanced salt solution. Monitoring of bevacizumab in the aqueous phase was conducted for up to 24 h, and its effect on interfacial tension was studied. Significant differences in bevacizumab partitioning were observed across endotamponades after 24 h. In silicone oils, bevacizumab was found exclusively in the aqueous phase, while in the other endotamponades, it accumulated in the gel phase (96.1% in porcine vitreous body, 83.5% in alginate, and 27.6% in PEG-based hydrogel). Bevacizumab significantly reduced interfacial tension (40 to 8 mN/m), possibly enhancing silicone oil emulsification. The type of endotamponade heavily influenced the bevacizumab concentration in the aqueous. The vitreous body and replacement hydrogels likely serve as a drug reservoir, highlighting the need for in vivo studies to explore these interactions prior to clinical application.

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Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils

Cited by 2 publications

References 50 publications

A review of human cornea finite element modeling: geometry modeling, constitutive modeling, and outlooks

A review of human cornea finite element modeling: geometry modeling, constitutive modeling, and outlooks

In Vitro Physicochemical and Pharmacokinetic Properties of Bevacizumab Dissolved in Silicone Oils Compared to Hydrogel-Substitutes and Porcine Vitreous Bodies

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