Viscoelastic properties of concentrated dispersions in water of soy lecithin

Freeze-dried eudragit-hyaluronan multicompartment liposomes to improve the intestinal bioavailability of curcumin

“…Dispersion A (1 or 1.5 ml) was mixed with dispersion B (1 or 0.5 ml) or dispersion C (1 or 0.5 ml) to obtain 2 ml of four different hydrating media. In a typical formulation, 2 ml of such media was added to 180 mg of P90G, left hydrating overnight and sonicated (25 cycles, 5 seconds on and 2 seconds off, 13 microns of probe amplitude) with a high intensity ultrasonic disintegrator (Soniprep 150, MSE Crowley, London, UK) [21]. The resulting vesicle dispersions were frozen at −80°C and freeze-dried for 24 h at -80°C and 0 mm Hg, using a Freeze-Dryer Criotecnica, (AMCOTA, Rome, Italy) [22].…”

Improving Oral Bioavailability and Pharmacokinetics of Liposomal Metformin by Glycerolphosphate–Chitosan Microcomplexation

“…The phospholipid mixture was swollen with 10 mL of metformin (Met, 100 mg/mL) and dextrose (50 mg/mL) PBS solution, at 51°C for 12 h (30,31). Dispersion was sonicated in a Soniprep 150 apparatus (MSE Crowley, London, United Kingdom) at 51°C for 2 min.…”

Influence of the electrical interface properties on the rheological behavior of sonicated soy lecithin dispersions

“…The use of phospholipids from natural sources facilitates large-scale industrial applications, due to the reduction of production costs when compared with synthetic phospholipids. As a general rule, the building-up of lipid vesicles in water, involves a concentrated lecithin dispersion processing [7]. In general, surfactants as soy lecithin often form supramolecular assemblies, such as bilayers sheets and vesicles.…”