Viscoelastic properties of the autologous bypass grafts: A comparative study among the small saphenous vein and internal thoracic artery

Khosravi, Arezoo; Bani, Milad Salimi; Bahreinizad, Hossein; Karimi, Alireza

doi:10.1016/j.artres.2017.06.007

Cited by 8 publications

(8 citation statements)

References 29 publications

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“…DMA was used in literature to evaluate the viscoelastic properties of blood vessels and their substitutes [ 47 ]. The storage modulus measured for GGE scaffold in this work is lower than reported by Khosravi et al for autologous graft (1.55 MPa for small saphenous vein and 5.79 MPa for internal thoracic artery [ 48 ]). However, native vessels showed a similar elastic behavior (with E’ around an order of magnitude above E’’) and values of tan delta close to 0.1 [ 48 ], as found in this work for GGE scaffolds.…”

Section: Resultscontrasting

confidence: 71%

“…The storage modulus measured for GGE scaffold in this work is lower than reported by Khosravi et al for autologous graft (1.55 MPa for small saphenous vein and 5.79 MPa for internal thoracic artery [ 48 ]). However, native vessels showed a similar elastic behavior (with E’ around an order of magnitude above E’’) and values of tan delta close to 0.1 [ 48 ], as found in this work for GGE scaffolds. Moreover, the viscoelastic characterization by DMA of scaffolds for vascular tissue engineering application carried out by Liu et al [ 49 ] reported values of storage modulus on the order of 10 4 Pa and values of loss modulus on the order of 10 3 Pa, similarly to what is obtained in this work.…”

Section: Resultscontrasting

confidence: 71%

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Biomimetic and Bioactive Small Diameter Tubular Scaffolds for Vascular Tissue Engineering

et al. 2022

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The present work aimed at the production and characterization of small caliber biomimetic and bioactive tubular scaffolds, which are able to favor the endothelialization process, and therefore potentially be suitable for vascular tissue engineering. The tubular scaffolds were produced using a specially designed mold, starting from a gelatin/gellan/elastin (GGE) blend, selected to mimic the composition of the extracellular matrix of native blood vessels. GGE scaffolds were obtained through freeze-drying and subsequent cross-linking. To obtain systems capable of promoting endothelization, the scaffolds were functionalized using two different bioactive peptides, Gly-Arg-Gly-Asp-Ser-Pro (GRGSDP) and Arg-Glu-Asp-Val (REDV). A complete physicochemical, mechanical, functional, and biological characterization of the developed scaffolds was performed. GGE scaffolds showed a good porosity, which could promote cell infiltration and proliferation and a dense external surface, which could avoid bleeding. Moreover, developed scaffolds showed good hydrophilicity, an elastic behavior similar to natural vessels, suitability for sterilization by an ISO accepted treatment, and an adequate suture retention strength. In vitro cell culture tests showed no cytotoxic activity against 3T3 fibroblasts. The functionalization with the REDV peptide favored the adhesion and growth of endothelial cells, while GRGDSP-modified scaffolds represented a better substrate for fibroblasts.

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Section: Resultscontrasting

confidence: 71%

Section: Resultscontrasting

confidence: 71%

Biomimetic and Bioactive Small Diameter Tubular Scaffolds for Vascular Tissue Engineering

et al. 2022

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“…To address this issue, Khosravi et al. [ 57 ] tested segments of saphenous vein and internal thoracic artery (5–7 cm length) which was transversely cut open with a scalpel and positioned in the equipment at 45° angle to determine the materials properties in the circumferential and axial directions. A sinusoidal dynamic force with a base static force and a peak dynamic force were applied to the specimens under varying frequencies from 1 to 2 Hz.…”

Section: Mechanical Characterization Of Blood Vessels and Their Substitutesmentioning

confidence: 99%

The mechanical characterization of blood vessels and their substitutes in the continuous quest for physiological-relevant performances. A critical review

Camasão

Diego

2021

Materials Today Bio

152

109

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During the last 50 years, novel biomaterials and tissue engineering techniques have been investigated to produce alternative vascular substitutes that recapitulate the unique elastic mechanical features of blood vessels. A large variation in mechanical characterization, including the test type, protocol, and data analysis, is present in literature which complicates the comparison among studies and prevents the blooming and the advancement of this field. In addition, a limited mechanical assessment of the substitute for the intended application is often provided. In this light, this review presents the mechanical environment of blood vessels, discusses their mechanical behavior responsible for the suited blood flow into the body (non-linearity, anisotropy, hysteresis, and compliance), and compares the mechanical properties reported in literature (obtained with compression, tensile, stress-relaxation, creep, dynamic mechanical analysis, burst pressure, and dynamic compliance tests). This perspective highlights that the mechanical properties extracted through conventional tests are not always suitable indicators of the mechanical performance during the working life of a vascular substitute. The available tests can be then strategically used at different stages of the substitute development, prioritizing the simplicity of the method at early stages, and the physiological pertinence at later stages, following as much as possible ISO standards in the field. A consistent mechanical characterization focused on the behavior to which they will be subdued during real life is one key and missing element in the quest for physiological-like mechanical performance of vascular substitutes.

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“… 32 , 33 , 34 , 35 , 36 Data on viscoelasticity is even more sparse and rare, but our data are consistent with recent literature. 10 , 37 , 38 , 39 Our echocardiographic measurements validate that indeed we are in the range of natural tissue properties, because the patch is fully compliant with the natural motion of the aorta, but the exact match with the tissue’s mechanical properties is hard to guarantee.…”

Section: Discussionmentioning

confidence: 55%

In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections

Balà,

Aranda,

Teixidó

et al. 2024

JACC: Basic to Translational Science

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Viscoelastic properties of the autologous bypass grafts: A comparative study among the small saphenous vein and internal thoracic artery

Cited by 8 publications

References 29 publications

Biomimetic and Bioactive Small Diameter Tubular Scaffolds for Vascular Tissue Engineering

Biomimetic and Bioactive Small Diameter Tubular Scaffolds for Vascular Tissue Engineering

The mechanical characterization of blood vessels and their substitutes in the continuous quest for physiological-relevant performances. A critical review

In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections

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