Viscoelasticity and cell swirling motion

Pajić‐Lijaković, Ivana; Milivojević, Milan

doi:10.1016/bs.aams.2022.05.002

Cited by 8 publications

(1 citation statement)

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“…The residual shear stress that accumulates in cells exerts work by generating shear stress torque (see Glossary) against tissue cohesiveness, and so can induce cell swirling motion (CSM) ( Pajic-Lijakovic and Milivojevic, 2022b ) ( Fig. 3 A).…”

Section: Shear Stress In Collective Cell Migrationmentioning

confidence: 99%

Response of cells and tissues to shear stress

Espina,

Cordeiro,

Milivojevic

et al. 2023

Journal of Cell Science

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Shear stress is essential for normal physiology and malignancy. Common physiological processes – such as blood flow, particle flow in the gut, or contact between migratory cell clusters and their substrate – produce shear stress that can have an impact on the behavior of different tissues. In addition, shear stress has roles in processes of biomedical interest, such as wound healing, cancer and fibrosis induced by soft implants. Thus, understanding how cells react and adapt to shear stress is important. In this Review, we discuss in vivo and in vitro data obtained from vascular and epithelial models; highlight the insights these have afforded regarding the general mechanisms through which cells sense, transduce and respond to shear stress at the cellular levels; and outline how the changes cells experience in response to shear stress impact tissue organization. Finally, we discuss the role of shear stress in collective cell migration, which is only starting to be appreciated. We review our current understanding of the effects of shear stress in the context of embryo development, cancer and fibrosis, and invite the scientific community to further investigate the role of shear stress in these scenarios.

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Section: Shear Stress In Collective Cell Migrationmentioning

confidence: 99%