Viscoelasticity of ECM and cells—origin, measurement and correlation

Liu, Zhiqiang; Ling, Si Da; Liang, Kaini; Chen, Yihan; Niu, Yudi; Sun, Lei; Li, Junyang; Du, Yanan

doi:10.1016/j.mbm.2024.100082

Mechanobiology in Medicine

2024

DOI: 10.1016/j.mbm.2024.100082

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Viscoelasticity of ECM and cells—origin, measurement and correlation

Zhiqiang Liu,

Si Da Ling,

Kaini Liang

et al.

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Tension at the gate: sensing mechanical forces at the blood–brain barrier in health and disease

Hansen,

Hollaus,

Kamermans

et al. 2024

J Neuroinflammation

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Microvascular brain endothelial cells tightly limit the entry of blood components and peripheral cells into the brain by forming the blood–brain barrier (BBB). The BBB is regulated by a cascade of mechanical and chemical signals including shear stress and elasticity of the adjacent endothelial basement membrane (BM). During physiological aging, but especially in neurological diseases including multiple sclerosis (MS), stroke, small vessel disease, and Alzheimer’s disease (AD), the BBB is exposed to inflammation, rigidity changes of the BM, and disturbed cerebral blood flow (CBF). These altered forces lead to increased vascular permeability, reduced endothelial reactivity to vasoactive mediators, and promote leukocyte transmigration. Whereas the molecular players involved in leukocyte infiltration have been described in detail, the importance of mechanical signalling throughout this process has only recently been recognized. Here, we review relevant features of mechanical forces acting on the BBB under healthy and pathological conditions, as well as the endothelial mechanosensory elements detecting and responding to altered forces. We demonstrate the underlying complexity by focussing on the family of transient receptor potential (TRP) ion channels. A better understanding of these processes will provide insights into the pathogenesis of several neurological disorders and new potential leads for treatment.

show abstract

Tension at the gate: sensing mechanical forces at the blood–brain barrier in health and disease

Hansen,

Hollaus,

Kamermans

et al. 2024

J Neuroinflammation

View full text Add to dashboard Cite

show abstract

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Viscoelasticity of ECM and cells—origin, measurement and correlation

Cited by 1 publication

References 142 publications

Tension at the gate: sensing mechanical forces at the blood–brain barrier in health and disease

Tension at the gate: sensing mechanical forces at the blood–brain barrier in health and disease

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