Due to the desirable and interesting applications of refrigerants in organic Rankine cycles, heat pumps, and refrigeration, engineers and researchers are becoming more interested in refrigerant properties. One of the most dominant thermophysical properties of these fluids is their normal boiling point (Tb). In the current study, a novel extreme learning method (ELM) and ensemble decision tree boosted algorithm (EDT Boosted) are proposed to forecast the normal boiling point from 16 different molecular groups and one topological index. To this end, a total of 334 data points of Tb are gathered to prepare and test ELM and EDT boosted algorithms. The visual and mathematical comparisons of model outputs and real Tb express that proposed models have great potential to predict Tb of refrigerant. Moreover, sensitivity analysis is applied to explain the effectiveness of input parameters on the determination of Tb for refrigerants.