Viscosity and electrolyte concentrations in gastric juice from cystic fibrosis children compared to healthy children

Abstract

The viscosity of gastric juice and the concentrations of sodium, potassium, calcium, magnesium and chloride ions were measured before and after stimulation with pentagastrin in 10 children with cystic fibrosis and compared to those in 10 healthy children of corresponding ages. The viscosity values followed the same patterns as those for the sodium and calcium ion concentrations and were higher in the cystic fibrosis group. The electrolyte concentrations in the basal and different post-stimulation fractions of the gastric juice were higher in the cystic fibrosis group. Significant differences between both groups could only be found in the electrolyte concentrations. The total secretion of each of the electrolytes was the same in both groups because along with the increased electrolyte concentration in the cystic fibrosis group there was a reduced volume of gastric juice. The dependence of viscosity on the individual electrolyte concentration is discussed. The differences in the viscosity and the electrolyte concentrations in gastric juice from the cystic fibrosis children seems to be due to changes in the process of gastric secretion and not due to the influence of swallowed saliva.

Magnesium in cystic fibrosis—Systematic review of the literature

“…The chance‐adjusted agreement between the two investigators on the application of the inclusion and exclusion criteria was 0.88. Twenty‐five original scientific reports published in English between 1964 and 2012 were retained for the final analysis, as depicted in Figure . They had been reported from the following countries: United States of America (N = 8), United Kingdom (N = 5), Germany (N = 3), Ireland (N = 2), Switzerland (N = 2), Australia (N = 1), Belgium (N = 1), Brazil (N = 1), Israel (N = 1), and Sweden (N = 1).…”

“…They had been reported from the following countries: United States of America (N = 8), United Kingdom (N = 5), Germany (N = 3), Ireland (N = 2), Switzerland (N = 2), Australia (N = 1), Belgium (N = 1), Brazil (N = 1), Israel (N = 1), and Sweden (N = 1). Ten reports addressed circulating (or urinary) magnesium level, 12 magnesium concentration in further body fluids or tissues, and three the therapeutic potential of magnesium supplementation …”

“…and Sweden (N ¼ 1). Ten reports addressed circulating (or urinary) magnesium level, 7-16 12 magnesium concentration in further body fluids or tissues, [17][18][19][20][21][22][23][24][25][26][27][28] and three the therapeutic potential of magnesium supplementation. [29][30][31]…”

“…19 Finally, the total gastric secretion of sodium, potassium, calcium, chloride and magnesium was similar in 10 cystic fibrosis children and 10 healthy controls. 25 Duodenal fluid magnesium was found to be marginally increased in a single cystic fibrosis patient. 17…”

Modeling the Fluid Dynamics in a Human Stomach to Gain Insight of Food Digestion

“…Physicochemical properties of gastric digesta Since the motor activity modeled in this study is associated with the ingestion of a 10% glucose solution meal, the gastric content was assumed to be a Newtonian fluid with a density of 1 kg/L and a viscosity of 10 −3 Pa.s (Schmidt and others 1981; Buia and Nguyen 2004). …”