Viscosity and Wettability of Hyaluronic Acid according to Antimicrobial Supplementation, Ionic Strength, and pH

Kho, Hong‐Seop; Chang, Ju Yong; Kim, Yoon-Young; Park, Moon Soo

doi:10.14476/jomp.2014.39.3.90

Cited by 1 publication

(2 citation statements)

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“…The results showed that effect of cationic polymer as CS induced the separation of the gel due to the charge of CS and the positive charge of PEC [5][6]. The low concentration HA observed the lowest viscosity [10][11] which affected the stability of the gel resulted in two-phase separation. The ratio of HA:P407 affected the gel forming which a high concentration of P407 reduced the gelation temperature while the low concentration of HA induced the coagulation of the solutions.…”

Section: Resultsmentioning

confidence: 99%

“…Spreadability of F3, F6, F9 were 75.36±0.3%, 47.10±0.5% and 14.95±0.2%, respectively and percentage of gel swelling were -25±0.01%, 15±0.01%, and 25±0.01%, respectively (shown in Table 1). HA help maintained the sol-to-gel system in solution state [10][11] but P407 manipulated the gel system resulting viscosity and spreadability of F3, F6, and F9 [9]. Rheology of F3 at both temperatures 4°C and 37°C followed Newtonian flow according to at those temperatures the gelation was not formed.…”

Section: Resultsmentioning

confidence: 99%

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Factors Affecting Gelation of Lidocaine Hydrochloride-Loaded Polyelectrolyte Complex Thermosensitivity Gel for Dry Socket Treatment

Supachawaroj

Limsitthichaikoon

2021

KEM

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Dry socket disease, a pocket wound caused by the tooth extraction that resulted in severe acute pain which requires a topical analgesic with rapidly pain reduction and suppress the pain until the wound healed. This study aimed to investigate factors affecting gelation temperature and gelation time of lidocaine hydrochloride (LH)-loaded polyelectrolyte complex (PEC) thermosensitivity gel for treating dry socket wound. The first factor was investigated the effects of the ratio of three different types of polymers as chitosan (CS), hyaluronic acid (HA) and poloxamer407 (P407) on the phase transition caused by temperature. The second factor was examined the effects of gel preparation methods. The results showed that increasing concentration of the cationic polymer as CS induced the separation of the solution to gel (sol-to-gel) system due to the charge of CS and the charge of PEC. The ratio of HA:P407 affected the gel forming which high concentration of P407 reduced the gelation temperature while low concentration of HA disturbed the sol-to-gel state causing coagulation. The viscosity, spreadability, and swelling were significantly increased due to the concomitant increased in each polymer, HA and P407. The particle of the formulation observed under microscope was found to be less than 1 µm. Phase inversion from sol-to-gel was found after a min at 23°C. Since gelation temperature of the purposed formula is supposed to form gel below 37°C within a short period of injection. The results of the study indicate the suitable sol-to-gel forming in the appropriate temperature and time which should be used for further investigation in the efficacy and safety.

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Section: Resultsmentioning

confidence: 99%