We propose notions of minimax and viscosity solutions for a class of fully nonlinear path-dependent PDEs with nonlinear, monotone, and coercive operators on Hilbert space. Our main result is well-posedness (existence, uniqueness, and stability) for minimax solutions. A particular novelty is a suitable combination of minimax and viscosity solution techniques in the proof of the comparison principle. One of the main difficulties, the lack of compactness in infinite-dimensional Hilbert spaces, is circumvented by working with suitable compact subsets of our path space. As an application, our theory makes it possible to employ the dynamic programming approach to study optimal control problems for a fairly general class of (delay) evolution equations in the variational framework. Furthermore, differential games associated to such evolution equations can be investigated following the Krasovskiȋ-Subbotin approach similarly as in finite dimensions. 8. Applications to differential games 33 Appendix A. Properties of solution sets of evolution equations 40 Appendix B. Other notions of solutions 45 B.1. Classical solutions 45 B.2. Viscosity solutions 47 References 48 C(S) := {u : S → R continuous with respect to d ∞ }, USC(S) := {u : S → R upper semi-continuous with respect to d ∞ }, LSC(S) := {u : S → R lower semi-continuous with respect to d ∞ }.Clearly, the elements of those function spaces are non-anticipating.2.2. The operator A, related trajectory spaces, and evolution equations. Throughout this work, we fix an operator A : [0, T ] × V → V * and assume that the following hypotheses hold. H(A): (i) The mappings t → A(t, x), v , v ∈ V , are measurable. (ii) Monotonicity: For a.e. t ∈ (0, T ) and every x, y ∈ V , A(t, x) − A(t, y), x − y ≥ 0. (iii) Hemicontinuity: For a.e. t ∈ (0, T ) and every x, y, v ∈ V , the mappings s → A(t, x + sy), v , [0, 1] → R, are continuous.