Viscosupplementation for Osteoarthritis of the Knee: A Key Opinion Leader Panel Discussion

Bert, Jack M.; Kenney, Jim; Sgaglione, Nicholas A.; McClelland, Scott; Brophy, Robert H.; Toth, J C; Ruane, Joseph J.; Ali, Yousaf; Arquette, Sheila; Dasa, Vinod; Lopes, Maria Carolina Barbosa Teixeira

doi:10.18553/jmcp.2018.24.6-a.s2

Cited by 9 publications

(8 citation statements)

References 45 publications

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“…Similarly, despite numerous studies clearly showing the beneficial effects of HA injections for pain reduction and recovery of joint function reports still persisted questioning the efficacy and utility of intra-articular injection of HA visco-supplementation procedures possibly fueled by inconsistent findings from clinical trials not conducted in a standard format. [449] www.advancedsciencenews.com www.advtherap.com [447] Robust debate continued in this area fueled by the inconsistent findings of some studies until in 2018 EUROVISC issued guidelines on how clinical trials should be conducted on HA visco-supplementation procedures.…”

Section: The Critical Importance Of Patient Selection In Visco-supplementioning

confidence: 99%

“…Furthermore, in July 2018, a key opinion leader panel discussion by ten leading expert physicians made two major recommendations. 1) “Visco‐supplementation with the use of hyaluronic acid injection is a treatment option for knee OA and can provide lubrication and elastic shock absorption, leading to potential pain relief, improved function, and reduced stiffness.” 2) The panel also concluded that “visco‐supplementation with HA injections represented a viable, cost‐effective, and safe alternative for the treatment of knee OA.”…”

Section: Future Researchmentioning

confidence: 99%

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Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Hayes

Melrose

2019

Advanced Therapeutics

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The aim of this study is to review developments in glycosaminoglycan and proteoglycan research relevant to cartilage repair biology and in particular the treatment of osteoarthritis (OA). Glycosaminoglycans decorate a diverse range of extracellular matrix and cell associated proteoglycans conveying structural organization and physico-chemical properties to tissues. They play key roles mediating cellular interactions with bioactive growth factors, cytokines, and morphogenetic proteins, and structural fibrillar collagens, cell interactive and extracellular matrix proteoglycans, and glycoproteins which define tissue function. Proteoglycan degradation detrimentally affects tissue functional properties. Therapeutic strategies have been developed to counter these degenerative changes. Neo-proteoglycans prepared from chondroitin sulfate or hyaluronan and hyaluronan or collagen-binding peptides emulate the interactive, water imbibing, weight bearing, and surface lubricative properties of native proteoglycans. Many neo-proteoglycans outperform native proteoglycans in terms of water imbibition, matrix stabilization, and resistance to proteolytic degradation. The biospecificity of recombinant proteoglycans however, provides precise attachment to native target molecules. Visco-supplements augmented with growth factors/therapeutic cells, hyaluronan, and lubricin (orthobiologicals) have the capacity to lubricate and protect cartilage, control inflammation, and promote cartilage repair and regeneration of early cartilage lesions and may represent a more effective therapeutic approach to the treatment of mild to moderate OA and deserve further study.Similar protective perineural net structures assembled from the lectican proteoglycan family and HA also occur in the CNS/PNS. These so called perineuronal nets are visualized by immunolocalization of MAb 1B5 (+) epitope in rat brain (e) and pericellular 1B5(+) epitope expression by isolated neurons (f). Scale bars 100 µm.

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Section: The Critical Importance Of Patient Selection In Visco-supplementioning

confidence: 99%

Section: Future Researchmentioning

confidence: 99%

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Hayes

Melrose

2019

Advanced Therapeutics

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“…cardiovascular) [24,25]. Additional clinically-used bioactive factor treatments include intra-articular corticosteroid and hyaluronan injections; the former provides both pain/inflammatory relief and anti-catabolic activity [26][27][28], while the latter can, to some extent, restore joint lubrication and provide some chondro-protective capacity [29,30]. However, retention of these bioactive factors within the joint is limited, as these agents are readily cleared due to their relatively small molecular size [31,32], and therefore only provide short-term benefits [28].…”

Section: Introductionmentioning

confidence: 99%

Bioactive factors for cartilage repair and regeneration: Improving delivery, retention, and activity

et al. 2019

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Articular cartilage is a remarkable tissue whose sophisticated composition and architecture allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the capacity to selfrepair, and injuries often progress to joint wide osteoarthritis (OA) resulting in debilitating pain and loss of mobility. Current palliative and surgical management provides short-term symptom relief, but almost always progresses to further deterioration in the long term. A number of bioactive factors, including drugs, corticosteroids, and growth factors, have been utilized in the clinic, in clinical trials, or in emerging research studies to stabilize the inflamed joint environment or to promote new cartilage tissue formation. However, these therapies remain limited in their duration and effectiveness. For this reason, current efforts are focused on improving the localization, retention, and activity of these bioactive factors. The purpose of this review is to highlight recent advances in drug delivery for the treatment of damaged or degenerated cartilage. First, we summarize material and modification techniques to improve the delivery of these factors to damaged tissue and enhance their retention and action within the joint environment. Second, we synthesize recent studies using novel methods to promote new cartilage formation via biofactor delivery, that have potential for improving future long-term clinical outcomes. Lastly, we review the emerging field of orthobiologics, using delivered and endogenous cells as drug-delivering "factories" to preserve and restore joint health. Enhancing drug delivery systems can improve both restorative and regenerative treatments for damaged cartilage.

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“…[ 34,35 ] Viscosupplementation of hyaluronic acid (HA) into the joint can provide lubrication and buffering, and offer a short‐term cartilage protection (1–3 months) to some extent. [ 7,36 ] Surgical managements including arthroscopic lavage, microfracture, and prosthetic replacement of joint are the last resort, which cost more. [ 37 ]…”

Section: Introductionmentioning

confidence: 99%

Stimuli‐Sensitive Nanotherapies for the Treatment of Osteoarthritis

Wang

et al. 2021

Macromolecular Bioscience

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Osteoarthritis (OA) is a common chronic inflammatory disease in the joints. It is one of the leading causes of disability with increasing morbidity, which has become one of the serious clinical issues. Current treatments would only provide temporary relief due to the lack of early diagnosis and effective therapy, and thus the replacement of joints may be needed when the OA deteriorates. Although the intra‐articular injection and oral administration of drugs are helpful for OA treatment, they are suffering from systemic toxicity, short retention time in joint, and insufficient bioavailability. Nanomedicine is potential to improve the drug delivery efficiency and targeting ability. In this focused progress review, the particle‐based drug loading systems that can achieve targeted and triggered release are summarized. Stimuli‐responsive nanocarriers that are sensitive to endogenous microenvironmental signals such as reactive oxygen species, enzymes, pH, and temperature, as well as external stimuli such as light for OA therapy are introduced in this review. Furthermore, the nanocarriers associated with targeted therapy and imaging for OA treatment are summarized. The potential applications of nanotherapies for OA treatment are finally discussed.

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Viscosupplementation for Osteoarthritis of the Knee: A Key Opinion Leader Panel Discussion

Cited by 9 publications

References 45 publications

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Bioactive factors for cartilage repair and regeneration: Improving delivery, retention, and activity

Stimuli‐Sensitive Nanotherapies for the Treatment of Osteoarthritis

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