Visfatin and retinol-binding protein 4 concentrations in lean, glucose-tolerant women with PCOS

Yildiz, Bülent O.; Bozdağ, Gürkan; Otegen, Umit; Harmancı, Ayla; Boynukalin, K.; Vural, Zehra; Kirazlı, Şerafettin; Yaralı́, Hakan

doi:10.1016/j.rbmo.2009.10.016

Cited by 38 publications

(46 citation statements)

References 40 publications

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“…Yildiz et al (2010) showed similar RBP4 serum levels in lean Asian PCOS and weight-matched controls. Conversely, Yildizhan et al (2011) reported significantly higher RBP4 and homeostatic model assessment (HOMA) index in obese PCOS women as compared with nonobese PCOS and control groups.…”

Section: Visfatinmentioning

confidence: 58%

“…Studies have shown higher visfatin levels in PCOS women as compared with controls of similar BMI and age (Plati et al 2010, Yildiz et al 2010, Cekmez et al 2011. In those studies, PCOS patients were more insulin resistant than control women, leading to the suggestion that visfatin could be a specific marker of insulin sensitivity, possibly contributing to the pathogenesis of PCOS (Plati et al 2010, Yildiz et al 2010, Cekmez et al 2011). In contrast, recent studies do not confirm the association of visfatin with PCOS.…”

Section: Visfatinmentioning

confidence: 99%

See 1 more Smart Citation

Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

Spritzer¹,

Lecke²,

Satler³

et al. 2015

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Polycystic ovary syndrome (PCOS), a complex condition that affects women of reproductive age, is characterized by ovulatory dysfunction and androgen excess. Women with PCOS present higher prevalence of obesity, central adiposity, and dyslipidemia, and face increased risk of type 2 diabetes. PCOS is closely linked to functional derangements in adipose tissue. Adipocytes seem to be prone to hypertrophy when exposed to androgen excess, as experienced by women with PCOS, and both adipose tissue hypertrophy and hyperandrogenism are related to insulin resistance. Hypertrophic adipocytes are more susceptible to inflammation, apoptosis, fibrosis, and release of free fatty acids. Disturbed secretion of adipokines may also impact the pathophysiology of PCOS through their influence on metabolism and on sex steroid secretion. Chronic low-grade inflammation in PCOS is also related to hyperandrogenism and to the hypertrophy of adipocytes, causing compression phenomena in the stromal vessels, leading to adipose tissue hypoperfusion and altered secretion of cytokines. Lifestyle changes are the first-line intervention for reducing metabolic risks in PCOS and the addition of an insulin-sensitizing drug might be required. Nevertheless, there is not sufficient evidence in favor of any specific pharmacologic therapies to directly oppose inflammation. Further studies are warranted to identify an adipokine that could serve as an indirect marker of adipocyte production in PCOS, representing a reliable sign of metabolic alteration in this syndrome.

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Section: Visfatinmentioning

confidence: 58%

Section: Visfatinmentioning

confidence: 99%

Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

Spritzer¹,

Lecke²,

Satler³

et al. 2015

Reproduction

269

206

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“…Pre vi o usly, Yıl dız et al 29 showed that the le vels of RBP4 in le an, nor mal glu co se-to lerant wo men with PCOS we re not dif fe rent than the con trol gro up and RBP4 le vels we re not cor rela ted with the cli ni cal, hor mo nal or bi oc he mi cal va ri ab les. They ha ve sug ges ted that the conf lic ting re sults ob ser ved in dif fe rent stu di es may be as so cia ted with ge og rap hi cal di ver gen ce of PCOS pa tients or com mer ci al im mu no as say va ri a ti ons.…”

Section: Discussionmentioning

confidence: 87%

“…They ha ve sug ges ted that the conf lic ting re sults ob ser ved in dif fe rent stu di es may be as so cia ted with ge og rap hi cal di ver gen ce of PCOS pa tients or com mer ci al im mu no as say va ri a ti ons. 29 Re ti nol is es sen ti al for fe ma le rep ro duc ti on, and re ti no ids ha ve be en sug ges ted to play a ro le in ova ri an ste ro i do ge ne sis, oocy te ma tu ra ti on, and for ma ti on of the cor pus lu te um. The enz ymes respon sib le for re ti nol me ta bo lism are pre sent in theca cells and may be al te red in PCOS.…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Retinol Binding Protein 4 Level in Non-Obese Women with Polycystic Ovary Syndrome

Akbay¹,

Gen²,

Muşlu³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : It has be en shown that in su lin re sis tan ce in wo men with polyc ystic ovary syndro me (PCOS) is in de pen dent of obe sity and body com po si ti on. Re ti nol bin ding pro te in 4 (RBP 4) is an adi po ki ne which plays a ro le in in su lin re sis tan ce in as so ci a ti on with glu co se trans por ter 4 (GLUT 4). In this study, we ai med to eva lu a te the re la ti ons hip of RBP4 with hor mo nal, me ta bo lic pa ra me ters and in ter le u kin-6 (IL-6) as a mar ker of subc li ni cal inf lam ma ti on in non-obe se pa ti ents with PCOS. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : The study gro ups we re com po sed of 21 non-obe se wo men with PCOS and 15 he althy, nor mally mens tru a ting wo men. Se rum con cen tra ti ons of RBP4 and IL-6 were de ter mi ned along with me ta bo lic and hor mo nal pa ra me ters. R Re e s su ul lt ts s: : HO MA-IR va lu es and serum RBP4 le vels in PCOS gro up we re sig ni fi cantly in cre a sed com pa red to the con trol gro up. RBP4 le vels we re sho wing po si ti ve cor re la ti on with IL-6 and 17-HP in the PCOS gro up. Ho we ver, there was no cor re la ti on bet we en se rum RBP4 le vels and me ta bo lic and hor mo nal pa ra me ters. Pa tients with se rum RBP4 con cen tra ti ons hig her than the me di an le vel we re mo re in su lin re sis tant than pa ti ents with se rum RBP con cen tra ti ons lo wer than the me di an le vel, and they had hig her insu lin and 17-hydroxy pro ges te ro ne va lu es. C Co on nc c l lu u s si i o on n: : Our da ta in di ca te that se rum RBP4 le vels incre a se in le an in su lin re sis tant wo men with PCOS. Event ho ugh this in cre a se was cor re la ted with in su lin re sis tan ce, pa ti ents with sig ni fi cantly high le vels of RBP4 had mo re in su lin re sis tan ce. Eleva ted se rum RBP4 le vels in non-obe se pa ti ents with PCOS was re la ted to IL-6, whe re as the re was no re la ti ons hip with ot her me ta bo lic pa ra me ters and tes tos te ro ne le vels. K Ke ey y W Wo or rd ds s: : RBP4 pro te in, hu man; polyc ystic ovary syndro me; inter le u kin-6; insu lin re sis tan ce Ö ÖZ ZE ET T A Am ma aç ç: : Po li kis tik over sen drom lu (PKOS) ka dın lar da in sü lin di ren ci nin obe zi te ve vü cut kom po zis yo nun dan ba ğım sız ol du ğu gös te ril miş tir. Re ti nol bağ la yı cı pro te in 4 (RBP 4) glu koz ta -şı yı cı sı 4 (GLUT 4) ile iliş ki li ola rak in sü lin di ren cin de rol oy na yan bir adi po kin dir. Bu ça lış ma da, RBP4'ün obez ol ma yan PKOS' lu has ta lar da hor mo nal, me ta bo lik pa ra met re ler ve subk li nik inf lamas yo nun bir gös ter ge si olan in ter lö kin-6 (IL-6) ile olan iliş ki si nin de ğer len di ril me si amaç lan dı. G Ge e --r re eç ç v ve e Y Yö ön n t te em m l le er r: : Nor mal ki lo lu 21 PCOS' lu has ta ve nor mal mens tru as yo nu olan 15 sağ lık lı ka dın kon trol gru bu ola rak ça lış ma ya alın dı. RBP4 ve IL-6 dü zey le ri me ta bo lik ve hor mo nal pa ra met reler le bir lik te de ğer len di ril di. B B...

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“…In a study involving 50 women with PCOS and 28 control women, the result showed indistinguishable levels of RBP4 between the two groups [8]. In a subsequent study on 27 lean women with PCOS and 19 age-and body mass index-matched controls, RBP4 levels were also shown to be similar between the two groups [9]. RBP4 therefore appears to show similar levels between PCOS cases and control women [2].…”

Section: Description Of the Studiesmentioning

confidence: 91%

Association between retinol-binding protein 4 and polycystic ovary syndrome: A meta-analysis

et al. 2014

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POLYCYSTIC OVARY SYNDROME (PCOS) is the most common endocrinopathy in women of reproductive age, with a prevalence of up to 10%. It is a heterogeneous syndrome with the characteristics of hirsutism, acne, anovulation, hyperandrogenemia, polycystic ovaries, and infertility [1]. It is associated with an adverse metabolic profile including insulin resistance. There is a clear association between obesity, the development of PCOS, and the severity of its phenotypic, biochemical and metabolic features [2]. About 50% of PCOS patients are obese [3]. It is currently assumed that adipose tissue is not only the main energy reservoir but also a pivotal endocrine organ secreting a variety of bioactive cytokines named adipokines, such as leptin, resis- Abstract. Studies have examined the association between retinol-binding protein 4 (RBP4) and polycystic ovary syndrome (PCOS). However, the results have been inconsistent. To investigate the association between RBP4 and PCOS, we performed a meta-analysis. The Cochrane Library, MEDLINE, the ISI Web of Science, and EMBASE were searched to identify all of the studies that examined the relationship between circulating RBP4 levels and PCOS. Standard mean difference (SMD) values and 95% confidence interval (CI) were estimated and pooled using meta-analysis methodology. A total of seven studies were involved in the meta-analysis, which included a total of 636 subjects (260 controls and 376 patients with PCOS). The RBP4 level was higher in PCOS patients than in non-PCOS patients (random effects MD (95% CI)=0.69, [0.20, 1.18], P=0.006). However, the RBP4 level was not higher in nonobese PCOS patients than in nonobese controls (random effects MD (95% CI)=0.38, [-0.21, 0.98], P=0.20). The effect size revealed that the RBP4 level was higher in overweight or obese PCOS patients than weight-matched controls (fixed effects MD (95% CI) =7.95, [5.96, 9.93], P<0.05). In the subgroup analysis by region, the RBP4 level was higher in PCOS patients in Asia than controls (random effects MD (95% CI)=0.85, [0.54, 1.15], P<0.05), but not in European PCOS patients compared with controls (random effects MD (95% CI)=0.34, [-1.12, 1.80], P=0.65). This subgroup analysis also showed that nonobese PCOS patients have higher RBP4 levels than controls in Asia. Our meta-analysis results indicated that RBP4 might be a useful tool for identifying PCOS women.

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Visfatin and retinol-binding protein 4 concentrations in lean, glucose-tolerant women with PCOS

Cited by 38 publications

References 40 publications

Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

Elevated Serum Retinol Binding Protein 4 Level in Non-Obese Women with Polycystic Ovary Syndrome

Association between retinol-binding protein 4 and polycystic ovary syndrome: A meta-analysis

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