2020
DOI: 10.2174/1573397115666190409112621
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Visfatin and Rheumatoid Arthritis: Pathogenetic Implications and Clinical Utility

Abstract: Objective: Analysis and generalization of data related to visfatin involvement in the pathogenesis of inflammation at various stages of rheumatoid arthritis. Data Synthesis: Visfatin is an adipocytokine which has also been identified in non-adipose tissues. It influences directly on the maturation of B cells, which are involved in autoantibody production and T cell activation. Visfatin can promote inflammation via regulation of pro-inflammatory cytokines including TNF, IL-1β and IL-6. The concentration of ci… Show more

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Cited by 11 publications
(8 citation statements)
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“…Interestingly, NAMPT is also up-regulated extracellularly in RA and acts as a proinflammatory cytokine in the serum of these patients. Thus, it has also been postulated as a potential therapeutic target in RA (34,35).…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, NAMPT is also up-regulated extracellularly in RA and acts as a proinflammatory cytokine in the serum of these patients. Thus, it has also been postulated as a potential therapeutic target in RA (34,35).…”
Section: Discussionmentioning
confidence: 99%
“…In breast cancer patients, the levels of serum NAMPT were higher compared with healthy individuals, suggesting that serum NAMPT may be a diagnostic parameter for breast cancer [ 31 ]. Compared to normal control subjects, higher concentration of circulating NAMPT was also observed in rheumatoid arthritis [ 32 ], osteoarthritis [ 33 ], and osteoporosis [ 22 ]. BMSCs from patients with NONFH exhibited weaker ability of osteogenic differentiation [ 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is expressed in many organs and tissues such as bone marrow, chondrocytes, hepatic cells, muscle, brain, kidney, spleen, testis, and lung, but preferentially in visceral adipose tissue and macrophages [56]. Visfatin acts as a potent proinflammatory cytokine with immunomodulatory effects that is highly expressed in many inflammatory diseases like rheumatoid arthritis, pneumonia, or irritable bowel syndrome [57][58][59]. In addition, it has complex molecular interactions with metabolic pathways and body homeostasis [60].…”
Section: Visfatinmentioning
confidence: 99%