Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

Türer, Çiğdem Coşkun; Ballı, Umut; Güven, Berrak; Çetinkaya, Burcu Özkan; Keleş, Gonca Çayır

doi:10.2334/josnusd.16-0116

Cited by 14 publications

(17 citation statements)

References 40 publications

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“…The influence of age on the visfatin concentration was minimized by selecting the subjects within the specified age group (25-45 years) since age is a known risk factor for both periodontitis and visfatin expression. 31 In the present study, the mean baseline salivary visfatin levels in group II and group III were 26.66 AE 2.24 and 38.22 AE 3.38 ng/mL (►Table 1, ►Fig. 1).…”

Section: Discussionsupporting

confidence: 44%

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The Role of Visfatin (Adipocytokine) Biomarker in Oral Health and Diseases among Nonobese Indian Population: A Proteomic Assay

Coutinho

Reddy

Chatterjee

et al. 2021

Global Medical Genetics

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Visfatin is an adipocytokine and a potential biomarker encoded by the nicotinamide phosphoribosyltransferase gene. It belongs to the nicotinic acid phosphoribosyltransferase family and involved in various metabolic processes and aging. The aim of this study was to evaluate the role of visfatin biomarker in oral diseases like periodontitis. A total of 60 patients (20–50 years) were included in this study, and they were divided into three groups. Group I consisted of 20 subjects with healthy periodontium, group II consisted of 20 subjects with generalized moderate gingivitis, and group III consisted of 20 subjects with generalized periodontitis. The clinical periodontal parameters, including plaque index, gingival index, probing pocket depth, and clinical attachment levels, were recorded, and saliva samples were collected. Salivary visfatin concentrations were assessed using standard enzyme-linked immunosorbent assay. The results of the study showed that the visfatin concentrations were higher in patients with gingivitis and periodontitis compared with those of healthy individuals. Visfatin was found highest in group III (38.22 ± 3.38 ng/mL) followed by group II (26.66 ± 2.24 ng/mL) and the group I (25.60 ± 2.19 ng/mL). Thus, salivary visfatin is a potential inflammatory biomarker and acts as a mediator in the pathogenesis of periodontal disease and, might serve as a diagnostic and therapeutic biomarker in oral diseases like periodontitis.

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Section: Discussionsupporting

confidence: 44%

“…The influence of age on the visfatin concentration was minimized by selecting the subjects within the specified age group (25–45 years) since age is a known risk factor for both periodontitis and visfatin expression. 31 …”

Section: Discussionmentioning

confidence: 99%

The Role of Visfatin (Adipocytokine) Biomarker in Oral Health and Diseases among Nonobese Indian Population: A Proteomic Assay

Coutinho

Reddy

Chatterjee

et al. 2021

Global Medical Genetics

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“…8 Mohamed, et al 22 (2015) reported a positive correlation between PD and visfatin levels in GCF, and they found that visfatin increased significantly the number of diseased sites. Türer, et al 23 (2015) showed that GCF and serum visfatin levels are higher in patients with chronic periodontitis than those with gingivitis and healthy controls. They also reported that visfatin levels were significantly decreased following periodontal treatment.…”

Section: Discussionmentioning

confidence: 99%

The role of visfatin levels in gingival crevicular fluid as a potential biomarker in the relationship between obesity and periodontal disease

et al. 2019

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Objectives Visfatin is an adipokine that plays an important role in immune functions as a growth factor, enzyme, and pro-inflammatory mediator. We aimed to determine the levels of visfatin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) in both obese/non-obese patients, with/without generalized chronic periodontitis (GCP). Methodology Patients were categorized as obese (O) (n=31) or non-obese (nO) (n=19). Groups were divided into four subgroups according to periodontal conditions: (1) periodontally healthy without obesity (nO-Ctrl); (2) GCP without obesity (nO-CP); (3) periodontally healthy with obesity (O-Ctrl); and (4) GCP with obesity (O-CP). Demographic variables, anthropometric and laboratory data were recorded. Periodontal parameters were measured at baseline and 3 rd months after either non-surgical periodontal treatment or calorie -restricted diet therapy. At the same time, GCF samples were taken from patients to analyze TNF-alpha, IL-6,and visfatin levels. Results Periodontal parameters were significantly higher in the O group than in the nO group (P<0.05). IL-6 levels were higher in the O group than in the nO group (P<0.001). The visfatin levels of the obese patients were reduceddecreased following the treatments (P<0.05). Cholesterol levels were higher in the O group than in the nO groups (P<0.05). IL-6 levels were higher in O-CP and O-Ctrl groups than in the nO-Ctrl group (P<0.05). Compared to the other groups, visfatin levels were significantly higher in the O-CP group but decreased following treatment (P<0.05). Conclusions Our findings suggest that visfatin and IL-6 levels in GCF are associated with the pathogenesis of obesity and periodontitis. Within the limits of this study, we considered that there might be an association between the lipid profile and periodontitis on systemically healthy individuals.

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“…Bu konuda çalışılmış diğer araştırmaların sonuçları da benzerlik göstermektedir. [15][16][17][18][19][20] Tüm bu literatürler ışığında, visfatin'in periodontal hastalıklarda infeksiyon varlığının tespiti için güvenilir bir biyobelirteç olarak kullanılabileceğini söyleyebiliriz.…”

Section: Visfatinunclassified

Peri̇odontal Enfeksi̇yonun Teşhi̇s Ve Prognozunda Umut Vadeden Bi̇yobeli̇rteçler

Ata¹,

Özkan²,

Çanakçı³

2020

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Periodontal hastalıklar çeşitli mikroorganizmalar tarafından başlatılmış olsa da, kompleks mikroflorası ve konak yanıtı periodontal durumu etkilemekte ve sipesifik hastalık belirteçlerini tanımlamayı zorlaştırmaktadır. Periodontal hastalık tanısında kullanılan sondalamada kanama, cep derinliği, klinik ataçman seviyesi ve radyolojik kemik miktarı gibi klinik periodontal parametreler, hastalığın şiddetinin, prognozunun ve tedaviye verilen yanıtın değerlendirilmesinde yetersiz kalmaktadır. Bu nedenle, dişeti oluğu sıvısı, tükürük ve serum öneklerinde tespit edilebilen çeşitli biyobelirteçler bu konuda bize umut ışığı olmaktadır. Son dönemlerde, doku savunma hücreleri olan adipositlerden salınan ve adipokinler olarak adlandırılan bazı proteinler rapor edilmiştir. Bu derlemede, çeşitli periodontal hastalıklarda çalışılmış adipokinler incelenmiş ve gelecekte adipokinlerin bir biyobelirteç olarak periodontoloji alanında uygulanabilirliği tartışılmıştır.

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Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

Cited by 14 publications

References 40 publications

The Role of Visfatin (Adipocytokine) Biomarker in Oral Health and Diseases among Nonobese Indian Population: A Proteomic Assay

The Role of Visfatin (Adipocytokine) Biomarker in Oral Health and Diseases among Nonobese Indian Population: A Proteomic Assay

The role of visfatin levels in gingival crevicular fluid as a potential biomarker in the relationship between obesity and periodontal disease

Peri̇odontal Enfeksi̇yonun Teşhi̇s Ve Prognozunda Umut Vadeden Bi̇yobeli̇rteçler

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