Visible and UV-curable chitosan derivatives for immobilization of biomolecules

Kim, Eunhye; Han, Ga-Dug; Kim, Jae-Won; Noh, Seung-Hyun; Lee, Jae-Gwan; Ito, Yoshihiro; Son, Tae‐Il

doi:10.1016/j.ijbiomac.2017.04.115

Cited by 12 publications

(8 citation statements)

References 55 publications

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Section: Photopolymerization Of Natural Polymersmentioning

confidence: 99%

“…In other studies, the natural chitosan was first reacted with monochloroacetic acid, to introduce carboxymethyl groups, followed by a reaction with N -(4-azidobenzoyloxy)succinimide, to introduce a UV-curable functional group. The new azidophenyl chitosan derivative has been proven to promote cell adhesion to a titanium surface and to immobilize protein-drugs or hydroxyapatite …”

Section: Photopolymerization Of Natural Polymersmentioning

confidence: 99%

“…Chitosan is a very attractive polysaccharide in the medical field for drug delivery, skin therapy, and tissue engineering, because chitosan is biocompatible and biodegradable and possesses anti-inflammatory and anticoagulant properties. 93 Many authors have applied growth factors to chitosan biomaterials, through both chemical modification, which involves toxicity issues due to the cross-linking agents and degradation byproducts, and physical encapsulation whose drawbacks are related to the low efficiency of immobilization (Figure 5f). 93 Immobilization of cells and protein-drugs into a chitosan matrix through photopolymerization is reported to be an emerging method.…”

Section: Photoinitiatorsmentioning

confidence: 99%

“…93 Many authors have applied growth factors to chitosan biomaterials, through both chemical modification, which involves toxicity issues due to the cross-linking agents and degradation byproducts, and physical encapsulation whose drawbacks are related to the low efficiency of immobilization (Figure 5f). 93 Immobilization of cells and protein-drugs into a chitosan matrix through photopolymerization is reported to be an emerging method. If the irradiation takes place using visible light, this is even more advantageous, because it can be done at the surface of the skin or inside the body without harming the human tissue.…”

Section: Photoinitiatorsmentioning

confidence: 99%

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Photopolymerization of Bio-Based Polymers in a Biomedical Engineering Perspective

Chiulan

Heggset²,

Voicu

et al. 2021

Biomacromolecules

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Photopolymerization is an effective method to covalently cross-link polymer chains that can be shaped into several biomedical products and devices. Additionally, polymerization reaction may induce a fluid–solid phase transformation under physiological conditions and is ideal for in vivo cross-linking of injectable polymers. The photoinitiator is a key ingredient able to absorb the energy at a specific light wavelength and create radicals that convert the liquid monomer solution into polymers. The combination of photopolymerizable polymers, containing appropriate photoinitiators, and effective curing based on dedicated light sources offers the possibility to implement photopolymerization technology in 3D bioprinting systems. Hence, cell-laden structures with high cell viability and proliferation, high accuracy in production, and good control of scaffold geometry can be biofabricated. In this review, we provide an overview of photopolymerization technology, focusing our efforts on natural polymers, the chemistry involved, and their combination with appropriate photoinitiators to be used within 3D bioprinting and manufacturing of biomedical devices. The reviewed articles showed the impact of different factors that influence the success of the photopolymerization process and the final properties of the cross-linked materials.

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Section: Photopolymerization Of Natural Polymersmentioning

confidence: 99%

Section: Photopolymerization Of Natural Polymersmentioning

confidence: 99%

Section: Photoinitiatorsmentioning

confidence: 99%

Section: Photoinitiatorsmentioning

confidence: 99%

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Photopolymerization of Bio-Based Polymers in a Biomedical Engineering Perspective

Chiulan

Heggset²,

Voicu

et al. 2021

Biomacromolecules

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“…In this sense, it is observed that, among the biopolymers used in orthopedic implants, chitosan stands out for its biocompatibility (Moura et al, 2017), antibacterial (Chang et al, 2017) and osteogenic properties (Lin et al, 2017), low cost (Vasilieva et al, 2017), biodegradability (He et al, 2017) and non-toxicity (Zubareva et al, 2017). It is highly promising for application in the biomedical area and in particular orthopedics (Kim et al, 2017;Yang et al, 2017), which can be in the form of gels (S. Wu et al, 2017), membranes (Carvalho et al, 2017), nanofibers (Sedghi et al, 2017), microparticles (Jeon et al, Research, Society and Development, v. 11, n. 3, e25911326646, 2022(CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v11i3.26646 2016 and nanoparticles (Sáez et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Chitosan/vancomycin antibacterial hydrogel for application in knee prostheses

Nepomuceno

Dias

Araújo

et al. 2022

RSD

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Chitosan hydrogels stand out for being an adhesive matrix, which presents biocompatibility, antibacterial and osteogenic properties, biodegradability, non-toxicity, capable of retaining, releasing, and distributing therapeutic agents (drugs) at the application site. Therefore, new strategies in the field of orthopedics have focused, above all, on limiting the initial preoperative and postoperative microbial adhesion to implant surfaces, modifying these surfaces, protecting them from eventual adhesions or releasing the antimicrobial agent. The production of chitosan-based hydrogels has been achieved through physical and chemical cross-linking routes. In this context, this research aimed to develop an antibacterial hydrogel based on chitosan and vancomycin for application in total knee arthroplasty and to prevent bacterial infections. For that, three crosslinking procedures of chitosan with genipin were investigated to obtain the hydrogels and drug delivery. For this purpose, initially, the raw materials chitosan, genipin and vancomycin were characterized by infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), pHmetry (pH) and microbiological tests. From the chemical crosslinking procedures evaluated, the drug release was investigated, and the hydrogels were characterized by FTIR, pH, viscosity, microbiology, and cytotoxicity. A new H5Q1GV hydrogel was obtained with good antibacterial activity, potentiated by the acidity of its pH 5.7, which showed good drug release in the first 4 hours after implantation, homogeneous, with ideal viscosity and adhesion for application through syringes in prosthesis surgery. knee and with excellent biocompatibility.

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Bioadhesives and Biosealants

Ito

2018

Photochemistry for Biomedical Applications

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Visible and UV-curable chitosan derivatives for immobilization of biomolecules

Cited by 12 publications

References 55 publications

Photopolymerization of Bio-Based Polymers in a Biomedical Engineering Perspective

Photopolymerization of Bio-Based Polymers in a Biomedical Engineering Perspective

Chitosan/vancomycin antibacterial hydrogel for application in knee prostheses

Bioadhesives and Biosealants

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